About the Authors
- Chunxiu Hu
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Contributed equally to this work with: Chunxiu Hu, Heng Wei
Affiliations CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China, Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
- Heng Wei
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Contributed equally to this work with: Chunxiu Hu, Heng Wei
Affiliations Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands, Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands
- Anita M. van den Hoek
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Affiliation Gaubius Laboratory, TNO, Leiden, The Netherlands
- Mei Wang
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Affiliations Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands, SU BioMedicine, Zeist, The Netherlands
- Rob van der Heijden
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Affiliation Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
- Gerwin Spijksma
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Affiliation Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
- Theo H. Reijmers
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Affiliation Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
- Jildau Bouwman
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Affiliations Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands, Netherlands Metabolomics Centre, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
- Suzan Wopereis
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Affiliation Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands
- Louis M. Havekes
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Affiliation Gaubius Laboratory, TNO, Leiden, The Netherlands
- Elwin Verheij
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Affiliation Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands
- Thomas Hankemeier
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Affiliations Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands, Netherlands Metabolomics Centre, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands
- Guowang Xu
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* E-mail: jan.vandergreef@tno.nl (JvdG); xugw@dicp.ac.cn (GX)
Affiliations CAS Key Laboratory of Separation Science for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China, Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands
- Jan van der Greef
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* E-mail: jan.vandergreef@tno.nl (JvdG); xugw@dicp.ac.cn (GX)
Affiliations Division of Analytical Biosciences, Leiden/Amsterdam Center for Drug Research, Leiden University, Leiden, The Netherlands, Sino-Dutch Centre for Preventive and Personalized Medicine, Zeist, The Netherlands, SU BioMedicine, Zeist, The Netherlands, Department of Earth, Environmental and Life Science, TNO, Zeist, The Netherlands
Competing Interests
The authors have read the journal's policy and have the following conflicts: Authors employed by SUB (MW and JvdG) have a potential conflict of interest as their company may benefit from knowledge of the product investigated, which is generated on the basis of the published data. The authors will however not receive additional salary, additional personal income, or any form of financial support based on this study or the direct outcome. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: MW JvdG. Performed the experiments: CH AMvdH. Analyzed the data: CH HW AMvdH. Contributed reagents/materials/analysis tools: GS LMH EV TH. Wrote the first draft of the paper: CH HW. Contributed to the writing of the paper: CH HW AvdH MW RvdH THR JB SW LH EV TH GX JvdG.