About the Authors

Manju George

manjuggm@gmail.com (MG); mnaramura@unmc.edu (MN); hband@unmc.edu (HB)

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Mark A. Rainey

Affiliation Department of Pharmacology, Creighton University, Omaha, Nebraska, United States of America

Mayumi Naramura

manjuggm@gmail.com (MG); mnaramura@unmc.edu (MN); hband@unmc.edu (HB)

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Kirk W. Foster

Affiliation Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Melissa S. Holzapfel

Affiliation Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Laura L. Willoughby

Affiliation Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

GuoGuang Ying

Affiliation Oncology Central Laboratory, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China

Rasna M. Goswami

Affiliation Abbott Laboratories, Abbott Park, Illinois, United States of America

Channabasavaiah B. Gurumurthy

Affiliation Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Vimla Band

Affiliations Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Simon C. Satchell

Affiliation Academic Renal Unit, University of Bristol, Bristol, United Kingdom

Hamid Band

manjuggm@gmail.com (MG); mnaramura@unmc.edu (MN); hband@unmc.edu (HB)

Affiliations Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Pathology and Microbiology, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Department of Genetics, Cell Biology and Anatomy, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America, Departments of Biochemistry and Molecular Biology, and Pharmacology and Experimental Neuroscience, College of Medicine, University of Nebraska Medical Center, Omaha, Nebraska, United States of America

Competing Interests

Ehd3 null mice and Ehd4 null mice were generated while MG, MAR, MN, GGY, RMG, CBG, VB and HB were at Evanston Northwestern Healthcare Research Institute, Evanston IL.

Author Contributions

Conceived and designed the experiments: MG. Performed the experiments: MG MAR CBG. Analyzed the data: MG KWF SCS. Contributed reagents/materials/analysis tools: KWF. Wrote the paper: MG. Conceived and designed Ehd3 null mouse: HB VB MN GGY. Secured funding: HB VB. Edited manuscript: MAR MN KWF CBG VB SCS HB. Technical assistance: LLW RMG MSH.