About the Authors

Amy S. Espeseth

Amy.Espeseth@merck.com (ASE); Daria.Hazuda@merck.com (DH)

Affiliation Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Rick Fishel

Affiliation Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Medical Center, Columbus, Ohio, United States of America

Daria Hazuda

Amy.Espeseth@merck.com (ASE); Daria.Hazuda@merck.com (DH)

Affiliation Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Qian Huang

Affiliation Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Min Xu

Affiliation Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Kristine Yoder

Affiliation Department of Molecular Virology, Immunology, and Medical Genetics, The Ohio State University Medical Center, Columbus, Ohio, United States of America

Honglin Zhou

Current address: Center for Resuscitation Science, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, United States of America

Affiliation Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania, United States of America

Competing Interests

AE, DH, QH, MX, and HZ were employees and stockholders of Merck & Co. at the time this work was conducted. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: ASE KY DH RF HZ. Performed the experiments: QH MX KY HZ. Analyzed the data: ASE RF DH KY HZ. Contributed reagents/materials/analysis tools: QH MX KY HZ. Wrote the manuscript: ASE KY DH RF.