About the Authors

Andreas Binder

Contributed equally to this work with: Andreas Binder, Denisa May

a.binder@neurologie.uni-kiel.de

Affiliation Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Denisa May

Contributed equally to this work with: Andreas Binder, Denisa May

Affiliation Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Ralf Baron

Affiliation Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Christoph Maier

Affiliation Department of Pain Management, BG Kliniken Bergmannsheil, Ruhr University Bochum, Bochum, Germany

Thomas R. Tölle

Affiliation Department of Neurology, Technische Universität München, Klinikum rechts der Isar, München, Germany

Rolf-Detlef Treede

Affiliation Center for Biomedicine and Medical Technology Mannheim, Ruprecht-Karls-University Heidelberg, Mannheim, Germany

Achim Berthele

Affiliation Department of Neurology, Technische Universität München, Klinikum rechts der Isar, München, Germany

Frank Faltraco

Affiliation Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Herta Flor

Affiliation Institute of Clinical and Cognitive Neuroscience, Central Institute for Mental Health, Ruprecht-Karls-University Heidelberg, Mannheim, Germany

Janne Gierthmühlen

Affiliation Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Sierk Haenisch

Affiliation Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Volker Huge

Affiliation Department of Anaesthesiology, Ludwig-Maximilians-University München, München, Germany

Walter Magerl

Affiliation Center for Biomedicine and Medical Technology Mannheim, Ruprecht-Karls-University Heidelberg, Mannheim, Germany

Christian Maihöfner

Affiliation Department of Neurology, University of Erlangen, Erlangen, Germany

Helmut Richter

Affiliation Department of Pain Management, BG Kliniken Bergmannsheil, Ruhr University Bochum, Bochum, Germany

Roman Rolke

Affiliation Department of Neurology, University Medical Center, Johannes-Gutenberg-University of Mainz, Mainz and Department of Palliative Care, University of Bonn, Bonn, Germany

Andrea Scherens

Affiliation Department of Pain Management, BG Kliniken Bergmannsheil, Ruhr University Bochum, Bochum, Germany

Nurcan Üçeyler

Affiliation Department of Neurology, University of Würzburg, Würzburg, Germany

Mike Ufer

Affiliation Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Gunnar Wasner

Affiliation Division of Neurological Pain Research and Therapy, Department of Neurology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Jihong Zhu

Affiliation Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Ingolf Cascorbi

Affiliation Institute of Experimental and Clinical Pharmacology, University Hospital Schleswig-Holstein, Campus Kiel, Kiel, Germany

Competing Interests

A. Binder received support for travel from the BMBF, honoraria for lectures from Grünenthal, Allergan and Pfizer, payment for development of educational presentations from Pfizer and travel/accommodation expenses from Pfizer, Allergan and Grünenthal and his institution received financial support from the BMBF. RB received support for travel from the BMBF, has consultancies with and received honoraria and travel/accommodation expenses from Pfizer, Genzyme, Grünenthal, Mundipharma, Allergan, Sanofi Pasteur, Medtronic, Eisai, UCB, Lilly, Astellas, received grants from Pfizer, Grünenthal, Genzyme, received payment for development of educational presentations from Pfizer, Medtronic and his institution received financial support from the BMBF. TT is board member at Pfizer, Lilly, Boehringer Grünenthal, and has consultancies with and received travel /accommodation expenses from Pfizer, Lilly, Boehringer, Grünenthal, Mundipharma, UCB/Schwarz. A. Berthele received honoraria and travel/accommodations expenses from Pfizer and his institution a grant from the BMBF. JG received support for travel from the BMBF and her institution received financial support from the BMBF. VH's institution received financial support from the BMBF. CMh received honoraria from Pfizer and travel/accommodation expenses from Allergan. RR is a board member at Astellas Pharma and received honoraria for lectures from Lilly and Pfizer. GW received honoraria and travel/accommodation expenses from Grünenthal, Medtronic, Pfizer, Mundipharma, his institution received financial support from the BMBF and Pfizer Pharma, and he received financial support for research from the National Health and Medical Research Council of Australia (NHMRC), the EFIC-Grünenthal-Grant (EGG), the Ministry of Science, Commerce and Transportation of Schleswig-Holstein, Germany and the Alexander von Humboldt-Stiftung. IC received honoraria and travel/accommodation expenses from MSD, Bayer-Schering and Sanofi Aventis for lectures. DM, RDT, FF, HF, SH, CM, AS, MU, NÜ, JZ, WM, HR have disclosed no competing interests. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: A. Binder RB C. Maier TT RDT A. Berthele SH WM MU IC. Performed the experiments: A. Binder DM C. Maier HF JG VH C. Maihöfner RR AS NÜ MU JZ. Analyzed the data: A. Binder DM RB C. Maier TT RDT A. Berthele FF JG SH WM C. Maihöfner HR GW JZ IC. Wrote the manuscript: A. Binder DM RB FF IC. Involved in revising the paper: C. Maier TT RDT A. Berthele HF JG SH VH WM C. Maihöfner HR RR AS NÜ MU GW JZ.