About the Authors

Debby Bogaert

d.bogaert@umcutrecht.nl

Affiliation Department of Paediatric Infectious Diseases and Immunology, University Medical Center Utrecht-Wilhelmina Children's Hospital, Utrecht, The Netherlands

Bart Keijser

Affiliation Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, TNO Quality of Life, Zeist, The Netherlands

Susan Huse

Affiliation Marine Biological Laboratory, Josephine Bay Paul Center for Comparative Molecular Biology and Evolution, Woods Hole, Massachusetts, United States of America

John Rossen

Affiliation Laboratory of Medical Microbiology and Immunology, St. Elisabeth Hospital, Tilburg, The Netherlands

Reinier Veenhoven

Affiliation Linnaeus Institute, Spaarne Hospital, Hoofddorp, The Netherlands

Elske van Gils

Affiliation Department of Paediatric Infectious Diseases and Immunology, University Medical Center Utrecht-Wilhelmina Children's Hospital, Utrecht, The Netherlands

Jacob Bruin

Affiliation Regional Laboratory of Public Health, Haarlem, The Netherlands

Roy Montijn

Affiliation Business Unit Food and Biotechnology Innovations, Microbial Genomics Group, TNO Quality of Life, Zeist, The Netherlands

Marc Bonten

Affiliations Department of Medical Microbiology, University Medical Center Utrecht, Utrecht, The Netherlands, Julius Center of Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands

Elisabeth Sanders

Affiliation Department of Paediatric Infectious Diseases and Immunology, University Medical Center Utrecht-Wilhelmina Children's Hospital, Utrecht, The Netherlands

Competing Interests

Dr. Veenhoven reports receiving grant support from GlaxoSmith Kline and Wyeth for vaccine studies and consulting fees for GlaxoSmithKline. Dr. Sanders reports receiving unrestricted grants from Wyeth and Baxter for research, consulting fees for Wyeth and GlaxoSmithKline, lecturing fees from Wyeth and grant support from Wyeth and GlaxoSmithKline for vaccine studies. These grants were not received for the research described in this paper. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. Authors employed by TNO (B.K., R.M.) have a potential conflict of interest as their organizations may benefit from a product or patent generated on the basis of the published data. In these cases, the authors will however not receive additional salary, additional personal income, or any form of financial support. In addition, it does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials. For all other authors no potential conflicts reported.

Author Contributions

Conceived and designed the experiments: DB BK ES. Performed the experiments: BK JB JR RM. Analyzed the data: DB BK SH. Contributed reagents/materials/analysis tools: DB BK SH RV ES. Wrote the paper: DB MB ES. Collected the clinical materials and epidemiological data: EvG.