About the Authors

Holger Perfahl

holger@perfahl.org

Affiliation Center Systems Biology, University of Stuttgart, Stuttgart, Germany

Helen M. Byrne

Affiliation Centre of Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom

Tingan Chen

Affiliation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

Veronica Estrella

Affiliation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

Tomás Alarcón

Affiliation Centre de Recerca Matemàtica, Campus de Bellaterra, Barcelona, Spain

Alexei Lapin

Affiliation Center Systems Biology, University of Stuttgart, Stuttgart, Germany

Robert A. Gatenby

Affiliation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

Robert J. Gillies

Affiliation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

Mark C. Lloyd

Affiliation H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America

Philip K. Maini

Affiliations Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom, Department of Biochemistry, Oxford Centre for Integrative Systems Biology, University of Oxford, Oxford, United Kingdom

Matthias Reuss

Affiliation Center Systems Biology, University of Stuttgart, Stuttgart, Germany

Markus R. Owen

Affiliation Centre of Mathematical Medicine and Biology, School of Mathematical Sciences, University of Nottingham, Nottingham, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: RG RJG ML. Performed the experiments: TC VE. Analyzed the data: HHP HMB TA AL PKM MR MO. Wrote the paper: HHP HMB TC VE TA AL RG RJG ML PKM MR MO. Mathematical modelling/computational implementation: HP HMB TA AL PKM MR MKO.