About the Authors

Jamileh Hashemi

Jamileh.Hashemi@ki.se

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Claire Worrall

Affiliation Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, Stockholm, Sweden

Daiana Vasilcanu

Affiliation Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, Stockholm, Sweden

Mårten Fryknäs

Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Luqman Sulaiman

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Mohsen Karimi

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Wen-Hui Weng

Current address: Department of Chemical Engineering and Biotechnology and Graduate Institute of Biotechnology, National Taipei University of Technology, Taipei, Taiwan

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Weng-Onn Lui

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Christina Rudduck

Current address: Department of Cytogenetics, The Children's Hospital at Westmead, Sydney, Australia

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Magnus Axelson

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Helena Jernberg-Wiklund

Affiliation Department of Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden

Leonard Girnita

Affiliation Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, Stockholm, Sweden

Olle Larsson

Affiliation Department of Oncology-Pathology, Karolinska Institutet, Karolinska University Hospital, CCK R8:04, Stockholm, Sweden

Catharina Larsson

Affiliation Department of Molecular Medicine and Surgery, Center for Molecular Medicine, Karolinska Institutet, Karolinska University Hospital, CMM L8:01, Stockholm, Sweden

Competing Interests

MA & OL are part-owners of a company (Axelar AB), US patent 7348358 Use of cyclolignans. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JH LG OL CL. Performed the experiments: JH CW DV LS MK WHW CR. Analyzed the data: JH CW MF MK WHW WOL LG OL CL. Contributed reagents/materials/analysis tools: JH MA HJW LG OL CL. Wrote the paper: JH CW DV LG OL CL. Critical reading: DV WOL HJW LG. Analyzed FISH data: CR.