About the Authors

Lucia Martiniova

Affiliations Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, Institute of Experimental Endocrinology, Slovak Academy of Sciences, Bratislava, Slovakia

Jie Lu

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Jeffrey Chiang

Affiliation Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America

Marcelino Bernardo

Affiliations Molecular Imaging Program, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, Laboratory Animal Sciences Program, SAIC-Frederick, NCI-Frederick, Frederick, Maryland, United States of America

Russell Lonser

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Zhengping Zhuang

karel@mail.nih.gov (KP); zhuangp@ninds.nih.gov (ZZ)

Affiliation Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, Maryland, United States of America

Karel Pacak

karel@mail.nih.gov (KP); zhuangp@ninds.nih.gov (ZZ)

Affiliation Reproductive and Adult Endocrinology Program, Eunice Kennedy Shriver, National Institutes of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America

Competing Interests

The Cooperative Research and Development Agreement (CRADA) between NINDS and Lixte Biotechnology Holdings, Inc. is not related to the work being reported. Dr. Jie Lu and Dr. Zhengping Zhuang are participants in a CRADA between NINDS, NIH and Lixte Biotechnology Holdings, Inc. (LBHI) to explore treatments for glioblastoma multiforma. LBHI supplied drug for the present study of pheochromocytoma. LBHI provided no other form of support, financial or any other. The structure of the compound has been published. The authors have no conflict of interest. Thus, the authors confirm that there are no competing interests, and CRADA between NINDS and Lixte Biotechnology Holdings, Inc. does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: LM RRL ZZ KP. Performed the experiments: LM JL JC MB. Analyzed the data: LM JL JC MB ZZ KP. Contributed reagents/materials/analysis tools: JL. Wrote the paper: LM RRL ZZ KP.