About the Authors

Yohei Hayashi

Contributed equally to this work with: Yohei Hayashi, Techuan Chan

Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

Techuan Chan

Contributed equally to this work with: Yohei Hayashi, Techuan Chan

Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

Masaki Warashina

Affiliation Genome Research Laboratories, Wako Pure Chemical Industries, Ltd., Hyogo, Japan

Masakazu Fukuda

Affiliation Department of Biological Sciences, Graduate School of Science, The University of Tokyo, Tokyo, Japan

Takashi Ariizumi

Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

Koji Okabayashi

Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

Naoya Takayama

Affiliation Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Makoto Otsu

Affiliation Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Koji Eto

Affiliation Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Miho Kusuda Furue

Affiliation Laboratory of Cell Cultures, Department of Disease Bioresources, National Institute of Biomedical Innovation, Osaka, Japan

Tatsuo Michiue

Affiliation Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan

Kiyoshi Ohnuma

kohnuma@vos.nagaokaut.ac.jp (KO); asashi@bio.c.u-tokyo.ac.jp (MA)

Affiliations Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan, Top Runner Incubation Center for Academia-Industry Fusion, Nagaoka University of Technology, Nagaoka, Japan

Hiromitsu Nakauchi

Affiliation Division of Stem Cell Therapy, Center for Stem Cell and Regenerative Medicine, Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Makoto Asashima

kohnuma@vos.nagaokaut.ac.jp (KO); asashi@bio.c.u-tokyo.ac.jp (MA)

Affiliations Department of Life Sciences (Biology), Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan, Organ Development Research Laboratory, National Institute of Advanced Industrial Science and Technology (AIST), Ibaraki, Japan

Competing Interests

Masaki Warashina is an employee of Genome Research Laboratories. The author joined this research for his training at the University of Tokyo and this research was independent from his affiliation. All the rights to the data and products derived from this research do not belong to the affiliation. All the authors adhere to all the PLoS ONE policies.

Author Contributions

Conceived and designed the experiments: YH TC MKF TM KO MA. Performed the experiments: YH TC MW MF TA NT MO MKF KO. Analyzed the data: YH TC TA KO MKF TM KO. Contributed reagents/materials/analysis tools: MW MF KO KE HN. Wrote the paper: YH TC MKF TM KO MA.