About the Authors

Helen Waller-Evans

Current address: School of Biosciences, Cardiff University, Cardiff, United Kingdom

Affiliation Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom

Simone Prömel

Current address: Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom

Affiliation Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom

Tobias Langenhan

Current address: of Physiology, University of Würzburg, Würzburg, Germany

Affiliation Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom

John Dixon

Affiliation Takeda Cambridge Ltd, Cambridge, United Kingdom

Dirk Zahn

Affiliation Takeda Cambridge Ltd, Cambridge, United Kingdom

William H. Colledge

Affiliation Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom

Joanne Doran

Affiliation Takeda Cambridge Ltd, Cambridge, United Kingdom

Mark B. L. Carlton

Affiliation Takeda Cambridge Ltd, Cambridge, United Kingdom

Ben Davies

Affiliation Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom

Samuel A. J. R. Aparicio

Affiliation Department of Pathology and Laboratory Medicine and BC Cancer Research Centre, University of British Columbia, Vancouver, Canada

Johannes Grosse

Affiliation Takeda Cambridge Ltd, Cambridge, United Kingdom

Andreas P. Russ

andreas.russ@bioch.ox.ac.uk

Affiliation Department of Biochemistry and Magdalen College, University of Oxford, Oxford, United Kingdom

Competing Interests

JDi, DZ, JDo, MBLC, and JG are employees of Takeda Cambridge Ltd. SAJRA is a consultant for Takeda Cambridge Ltd. MBLC, SAJRA, and APR are founders of Paradigm Therapeutics Ltd., which was acquired by Takeda Cambridge Ltd. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: HWE SP MC SA AR. Performed the experiments: HWE SP TL JD DZ WC JD BD AR. Analyzed the data: HWE SP TL AR. Contributed reagents/materials/analysis tools: JG. Wrote the paper: AR.