About the Authors

Kenichi Kakefuda

Affiliation Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

Atsushi Oyagi

Affiliation Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

Mitsue Ishisaka

Affiliation Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

Kazuhiro Tsuruma

Affiliation Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

Masamitsu Shimazawa

Affiliation Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

Koichi Yokota

Affiliation Carna Biosciences, In., Kobe, Japan

Yasuhito Shirai

Affiliation Biosignal Research Center, Kobe University, Kobe, Japan

Kyoji Horie

Affiliation Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan

Naoaki Saito

Affiliation Biosignal Research Center, Kobe University, Kobe, Japan

Junji Takeda

Affiliation Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Japan

Hideaki Hara

hidehara@gifu-pu.ac.jp

Affiliation Molecular Pharmacology, Department of Biofunctional Evaluation, Gifu Pharmaceutical University, Gifu, Japan

Competing Interests

Contributing author K. Yokota is an employee of Carna Biosciences, Inc. The other authors declare that no competing interests exist. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: KT MS NS HH. Performed the experiments: KK AO MI KY YS KH NS JT. Analyzed the data: KK. Contributed reagents/materials/analysis tools: AO MI KH JT. Wrote the paper: KK.