About the Authors

Alaa Alkhalaf

Affiliations Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Diabetes Centre, Isala Clinics, Zwolle, The Netherlands

Petra Zürbig

zuerbig@mosaiques-diagnostics.com

Affiliation Mosaiques diagnostics GmbH, Hannover, Germany

Stephan J. L. Bakker

Affiliation Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

Henk J. G. Bilo

Affiliations Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands, Diabetes Centre, Isala Clinics, Zwolle, The Netherlands

Marie Cerna

Affiliation Department of General Biology and Genetics, Third Faculty of Medicine, Charles University, Prague, Czech Republic

Christine Fischer

Affiliation Institute of Human Genetics, Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany

Sebastian Fuchs

Affiliation Human Nutrition & Metabolism Research and Training Center, Institute of Molecular Biosciences, Karl Franzens University of Graz, Graz, Austria

Bart Janssen

Affiliation Institute of Human Genetics, Medical Faculty Heidelberg, University of Heidelberg, Heidelberg, Germany

Karel Medek

Affiliation Department of General Biology and Genetics, Third Faculty of Medicine, Charles University, Prague, Czech Republic

Harald Mischak

Affiliations Mosaiques diagnostics GmbH, Hannover, Germany, Faculty of Medicine, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Glasgow, United Kingdom

Johannes M. Roob

Affiliation Clinical Division of Nephrology and Hemodialysis, Department of Internal Medicine, Medical University of Graz, Graz, Austria

Kasper Rossing

Affiliation Steno Diabetes Center, Gentofte, Denmark

Peter Rossing

Affiliation Steno Diabetes Center, Gentofte, Denmark

Ivan Rychlík

Affiliation Second Department of Internal Medicine, Third Faculty of Medicine, Charles University, Prague, Czech Republic

Harald Sourij

Affiliation Division of Endocrinology and Nuclear Medicine, Department of Internal Medicine, Medical University of Graz, Graz, Austria

Beate Tiran

Affiliation Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria

Brigitte M. Winklhofer-Roob

Affiliation Human Nutrition & Metabolism Research and Training Center, Institute of Molecular Biosciences, Karl Franzens University of Graz, Graz, Austria

Gerjan J. Navis

Affiliation Department of Internal Medicine, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands

for the PREDICTIONS Group

Membership of the PREDICTIONS Group is provided in the Acknowledgments.

Competing Interests

H. Mischak is co-founder and a shareholder of mosaiques diagnostics GmbH (Hannover, Germany). P. Zürbig is an employee of mosaiques diagnostics GmbH. P. Rossing has served as a consultant to Merck, Bristol-Myers Squibb and AstraZeneca, has received research grants from Novartis and has been a member of speakers bureaus sponsored by Novartis, Boehringer Ingelheim, and Sanofi-Aventis. This does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: PZ SJB BJ HM PR IR BMWR GN. Performed the experiments: AA PZ SF KM KR HS BT. Analyzed the data: PZ CF HM. Contributed reagents/materials/analysis tools: HJB MC JMR IR BMWR GN. Wrote the paper: AA PZ SJB HM GN.