About the Authors

Meredith H. Shaffer

Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Yanping Huang

Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Evann Corbo

Affiliation Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Gregory F. Wu

Affiliation Department of Neurology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Marielena Velez

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

John K. Choi

Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Ichiko Saotome

Affiliation Department of Pathology, Massachusetts General Hospital (MGH) Cancer Center and Harvard Medical School, Charlestown, Massachusetts, United States of America

Judy L. Cannon

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

Andrea I. McClatchey

Affiliation Department of Pathology, Massachusetts General Hospital (MGH) Cancer Center and Harvard Medical School, Charlestown, Massachusetts, United States of America

Anne I. Sperling

Affiliation Department of Medicine, University of Chicago, Chicago, Illinois, United States of America

Jonathan S. Maltzman

Affiliation Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Paula M. Oliver

Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Avinash Bhandoola

Affiliation Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Terri M. Laufer

Affiliation Department of Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Janis K. Burkhardt

jburkhar@mail.med.upenn.edu

Affiliations Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MHS EC GW MV JSM PMO AB TML JKB. Performed the experiments: MHS YH EC GW MV. Analyzed the data: MHS YH EC GW MV JKC JSM PMO AB TML JKB. Contributed reagents/materials/analysis tools: IS JLC AIM AIS JSM PMO AB TML JKB. Wrote the paper: MHS YH JKB. Oversaw and coordinated the project: JKB.