About the Authors
- Janine Kimpel
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Contributed equally to this work with: Janine Kimpel, Stephen E. Braun
Affiliation Angewandte Virologie und Gentherapie, Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany
- Stephen E. Braun
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Contributed equally to this work with: Janine Kimpel, Stephen E. Braun
Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
- Gang Qiu
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Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
- Fay Eng Wong
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Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
- Michelle Conolle
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Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America
- Jörn E. Schmitz
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Affiliation Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America
- Christian Brendel
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Affiliation Angewandte Virologie und Gentherapie, Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany
- Laurent M. Humeau
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Affiliation VIRxSYS Corporation, Gaithersburg, Maryland, United States of America
- Boro Dropulic
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Current address: Lentigen Corporation, Gaithersburg, Maryland, United States of America
Affiliation VIRxSYS Corporation, Gaithersburg, Maryland, United States of America
- John J. Rossi
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Affiliation Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America
- Annemarie Berger
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Affiliation J.W. Goethe University Hospital, Institute for Medical Virology, Frankfurt, Germany
- Dorothee von Laer
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Affiliations Angewandte Virologie und Gentherapie, Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany, Sektion Virologie, Medizinische Universität Innsbruck, Innsbruck, Austria
- R. Paul Johnson
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* E-mail: paul_johnson@hms.harvard.edu
Affiliations Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America, Ragon Institute of MGH, Massachusetts Institute of Technology, and Harvard, and Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America
Competing Interests
DvL has patents related to the maC46 membrane fusion inhibitor. JR has patents related to the shI RNA inhibitor. BD and LMH have patents related to the antisense envelope inhibitor. At the time this research was conducted, VIRxSYS and Lentigen provided salary support to LMH and BD respectively, and VIRxSYS supported the production of VRX494, but neither company provided research support for the studies conducted in the RPJ and DvL laboratories. This support does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.
Author Contributions
Conceived and designed the experiments: JK SEB JES AB DvL RPJ. Performed the experiments: JK SEB GQ FEW MC CB AB. Analyzed the data: JK SEB GQ FEW MC AB DvL RPJ. Contributed reagents/materials/analysis tools: LMH BD JJR AB. Wrote the paper: JK SEB DvL RPJ.