About the Authors

Janine Kimpel

Contributed equally to this work with: Janine Kimpel, Stephen E. Braun

Affiliation Angewandte Virologie und Gentherapie, Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany

Stephen E. Braun

Contributed equally to this work with: Janine Kimpel, Stephen E. Braun

Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

Gang Qiu

Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

Fay Eng Wong

Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

Michelle Conolle

Affiliation Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America

Jörn E. Schmitz

Affiliation Division of Viral Pathogenesis, Department of Medicine, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America

Christian Brendel

Affiliation Angewandte Virologie und Gentherapie, Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany

Laurent M. Humeau

Affiliation VIRxSYS Corporation, Gaithersburg, Maryland, United States of America

Boro Dropulic

Current address: Lentigen Corporation, Gaithersburg, Maryland, United States of America

Affiliation VIRxSYS Corporation, Gaithersburg, Maryland, United States of America

John J. Rossi

Affiliation Division of Molecular Biology, Beckman Research Institute of the City of Hope, Duarte, California, United States of America

Annemarie Berger

Affiliation J.W. Goethe University Hospital, Institute for Medical Virology, Frankfurt, Germany

Dorothee von Laer

Affiliations Angewandte Virologie und Gentherapie, Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus, Frankfurt, Germany, Sektion Virologie, Medizinische Universität Innsbruck, Innsbruck, Austria

R. Paul Johnson

paul_johnson@hms.harvard.edu

Affiliations Division of Immunology, New England Primate Research Center, Harvard Medical School, Southborough, Massachusetts, United States of America, Ragon Institute of MGH, Massachusetts Institute of Technology, and Harvard, and Infectious Disease Unit, Massachusetts General Hospital, Charlestown, Massachusetts, United States of America

Competing Interests

DvL has patents related to the maC46 membrane fusion inhibitor. JR has patents related to the shI RNA inhibitor. BD and LMH have patents related to the antisense envelope inhibitor. At the time this research was conducted, VIRxSYS and Lentigen provided salary support to LMH and BD respectively, and VIRxSYS supported the production of VRX494, but neither company provided research support for the studies conducted in the RPJ and DvL laboratories. This support does not alter the authors' adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: JK SEB JES AB DvL RPJ. Performed the experiments: JK SEB GQ FEW MC CB AB. Analyzed the data: JK SEB GQ FEW MC AB DvL RPJ. Contributed reagents/materials/analysis tools: LMH BD JJR AB. Wrote the paper: JK SEB DvL RPJ.