About the Authors

Laura E. Cox

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Laura Ferraiuolo

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Emily F. Goodall

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Paul R. Heath

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Adrian Higginbottom

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Heather Mortiboys

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Hannah C. Hollinger

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Judith A. Hartley

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Alice Brockington

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Christine E. Burness

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Karen E. Morrison

Affiliation Department of Neurology, University of Birmingham, Birmingham, East Midlands, United Kingdom

Stephen B. Wharton

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Andrew J. Grierson

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Paul G. Ince

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Janine Kirby

Contributed equally to this work with: Janine Kirby, Pamela J. Shaw

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Pamela J. Shaw

Contributed equally to this work with: Janine Kirby, Pamela J. Shaw

pamela.shaw@sheffield.ac.uk

Affiliation Department of Neuroscience, University of Sheffield, Sheffield, South Yorkshire, United Kingdom

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: LEC EFG PRH AH HM SBW AG PGI JK PJS. Performed the experiments: LEC LF EFG PRH AH HM JAH JK. Analyzed the data: LEC LF EFG PRH AH HM SBW AG PGI JK PJS. Contributed reagents/materials/analysis tools: LEC LF EFG PRH AH HM HCH JAH AB KM SBW AG PGI JK PJS. Wrote the paper: LEC LF PRH AH HM AG PGI JK PJS. Provided the clinical data and blood samples for the study: PJS HCH JAH AB CEB KM.