Efficient Estimation of the Robustness Region of Biological Models with Oscillatory Behavior

Mochamad Apri; Jaap Molenaar; Maarten de Gee; George van Voorn

doi:10.1371/journal.pone.0009865

Loading metrics

Open Access

Peer-reviewed

Research Article

Efficient Estimation of the Robustness Region of Biological Models with Oscillatory Behavior

Mochamad Apri ,

* E-mail: mochamad.apri@wur.nl

Affiliations Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands
⨯
Jaap Molenaar,

Affiliations Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands
⨯
Maarten de Gee,

Affiliation Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands
⨯
George van Voorn

Affiliation Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands
⨯

Efficient Estimation of the Robustness Region of Biological Models with Oscillatory Behavior

Mochamad Apri,
Jaap Molenaar,
Maarten de Gee,
George van Voorn

Published: April 1, 2010
https://doi.org/10.1371/journal.pone.0009865

About the Authors

Mochamad Apri

* E-mail: mochamad.apri@wur.nl

Affiliations Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

Jaap Molenaar

Affiliations Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands, Netherlands Consortium for Systems Biology, Amsterdam, The Netherlands

Maarten de Gee

Affiliation Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands

George van Voorn

Affiliation Biometris, Department of Mathematical and Statistical Methods, Wageningen University, Wageningen, The Netherlands

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MA JM MdG GvV. Performed the experiments: MA GvV. Analyzed the data: MA JM MdG GvV. Contributed reagents/materials/analysis tools: MA JM MdG. Wrote the paper: MA JM MdG GvV.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Bifurcation theory
Is the Subject Area "Bifurcation theory" applicable to this article?

Thanks for your feedback.
Approximation methods
Is the Subject Area "Approximation methods" applicable to this article?

Thanks for your feedback.
Eigenvalues
Is the Subject Area "Eigenvalues" applicable to this article?

Thanks for your feedback.
Circadian oscillators
Is the Subject Area "Circadian oscillators" applicable to this article?

Thanks for your feedback.
Soil perturbation
Is the Subject Area "Soil perturbation" applicable to this article?

Thanks for your feedback.
Adenosine
Is the Subject Area "Adenosine" applicable to this article?

Thanks for your feedback.
Dictyostelium discoideum
Is the Subject Area "Dictyostelium discoideum" applicable to this article?

Thanks for your feedback.
Mathematical models
Is the Subject Area "Mathematical models" applicable to this article?

Thanks for your feedback.