About the Authors

Junichi Soh

Contributed equally to this work with: Junichi Soh, Naoki Okumura

Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Naoki Okumura

Contributed equally to this work with: Junichi Soh, Naoki Okumura

Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

William W. Lockwood

Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

Hiromasa Yamamoto

Affiliation Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Hisayuki Shigematsu

Affiliation Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

Wei Zhang

Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Raj Chari

Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

David S. Shames

Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Oncology Diagnostics, Genentech Inc., South San Francisco, California, United States of America

Ximing Tang

Affiliation Department of Thoracic/Head and Neck, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Calum MacAulay

Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

Marileila Varella-Garcia

Affiliation Department of Medicine, University of Colorado Health Sciences Center, Aurora, Colorado, United States of America

Tõnu Vooder

Affiliation Department of Biotechnology, Institute of Molecular and Cell Biology, Tartu University Hospital, Tartu University, Tartu, Estonia

Ignacio I. Wistuba

Affiliations Department of Thoracic/Head and Neck, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, Texas, United States of America

Stephen Lam

Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

Rolf Brekken

Affiliation Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Shinichi Toyooka

Affiliation Department of Cancer and Thoracic Surgery, Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama, Japan

John D. Minna

Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pharmacology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Wan L. Lam

Affiliation Departments of Cancer Genetics and Developmental Biology, and Cancer Image, British Columbia Cancer Research Centre, Vancouver, British Columbia, Canada

Adi F. Gazdar

Adi.Gazdar@UTSouthwestern.edu

Affiliations Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

Competing Interests

Dr. Gazdar is a paid consultant/lecturer for AstraZeneca PLC. Dr. Garcia recieves Research Funding >10,000 from AstraZeneca, Genentech and OSI; Honorarium <10,000 from Roche. Dr. Minna receives research support from AstraZeneca PLC. David Shames is an employee of Genentech Inc.

Author Contributions

Conceived and designed the experiments: JS NO WWL HY HS RC DSS CM IIW SL RAB JDM WLL AFG. Performed the experiments: JS NO WWL HY HS WZ RC DSS XT CM MVG. Analyzed the data: JS WWL RC CM AFG. Contributed reagents/materials/analysis tools: MVG TV IIW SL RAB ST JDM WLL AFG. Wrote the paper: JS NO WWL HY WZ DSS XT MVG IIW RAB ST JDM AFG.