About the Authors

Saif Ahmad

Affiliation Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Tim Ramsay

Affiliation Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Lothar Huebsch

Affiliation Department of Clinical Hematology, University of Ottawa, Ottawa, Ontario, Canada

Sarah Flanagan

Affiliation Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Sheryl McDiarmid

Affiliation Department of Clinical Hematology, University of Ottawa, Ottawa, Ontario, Canada

Izmail Batkin

Affiliation Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Lauralyn McIntyre

Affiliations Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Department of Critical Care Medicine, University of Ottawa, Ottawa, Ontario, Canada

Sudhir R. Sundaresan

Affiliation Division of Thoracic Surgery, University of Ottawa, Ottawa, Ontario, Canada

Donna E. Maziak

Affiliation Division of Thoracic Surgery, University of Ottawa, Ottawa, Ontario, Canada

Farid M. Shamji

Affiliation Division of Thoracic Surgery, University of Ottawa, Ottawa, Ontario, Canada

Paul Hebert

Affiliations Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Department of Critical Care Medicine, University of Ottawa, Ottawa, Ontario, Canada

Dean Fergusson

Affiliation Ottawa Hospital Research Institute, Ottawa, Ontario, Canada

Alan Tinmouth

Affiliations Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Department of Clinical Hematology, University of Ottawa, Ottawa, Ontario, Canada

Andrew J. E. Seely

aseely@ottawahospital.on.ca

Affiliations Ottawa Hospital Research Institute, Ottawa, Ontario, Canada, Division of Thoracic Surgery, University of Ottawa, Ottawa, Ontario, Canada, Department of Critical Care Medicine, University of Ottawa, Ottawa, Ontario, Canada

Competing Interests

Andrew J.E. Seely founded Therapeutic Monitoring Systems in order to commercialize patented Continuous Individualized Multiorgan Variability Analysis (CIMVA) technology, with the objective of delivering variability-directed clinical decision support to improve quality and efficiency of care.

Author Contributions

Conceived and designed the experiments: LH AJES. Performed the experiments: SA SF SM. Analyzed the data: SA TR LH SF IB LM SRS DEM FMS PH DF AJES. Contributed reagents/materials/analysis tools: LH SM. Wrote the paper: SA TR AJES. Contributed to the formulation of the research protocol, interpretation of the results and preparation of the manuscript: SA TR LH SF SM IB LM SRS DEM FMS PH DF AT. Principally involved in the analysis and drafting of the manuscript: SA AJES.