Lactate Dehydrogenase-Elevating Virus Induces Systemic Lymphocyte Activation via TLR7-Dependent IFNα Responses by Plasmacytoid Dendritic Cells

Christoph G. Ammann; Ronald J. Messer; Karin E. Peterson; Kim J. Hasenkrug

doi:10.1371/journal.pone.0006105

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Peer-reviewed

Research Article

Lactate Dehydrogenase-Elevating Virus Induces Systemic Lymphocyte Activation via TLR7-Dependent IFNα Responses by Plasmacytoid Dendritic Cells

Christoph G. Ammann,

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Ronald J. Messer,

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Karin E. Peterson,

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯
Kim J. Hasenkrug

* E-mail: khasenkrug@nih.gov

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America
⨯

Lactate Dehydrogenase-Elevating Virus Induces Systemic Lymphocyte Activation via TLR7-Dependent IFNα Responses by Plasmacytoid Dendritic Cells

Christoph G. Ammann,
Ronald J. Messer,
Karin E. Peterson,
Kim J. Hasenkrug

Published: July 1, 2009
https://doi.org/10.1371/journal.pone.0006105

About the Authors

Christoph G. Ammann

Affiliation Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America

Ronald J. Messer

Karin E. Peterson

Kim J. Hasenkrug

* E-mail: khasenkrug@nih.gov

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: CGA KJH. Performed the experiments: CGA RJM KEP. Analyzed the data: CGA. Wrote the paper: CGA KJH.

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Lymphocytes
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Respiratory infections
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B cells
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Toll-like receptors
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Blood plasma
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Genetically modified animals
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Interferons
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Lymphocyte activation
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