In Silico Simulation of Corticosteroids Effect on an NFkB- Dependent Physicochemical Model of Systemic Inflammation

Panagiota T. Foteinou; Steve E. Calvano; Stephen F. Lowry; Ioannis P. Androulakis

doi:10.1371/journal.pone.0004706

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Open Access

Peer-reviewed

Research Article

In Silico Simulation of Corticosteroids Effect on an NFkB- Dependent Physicochemical Model of Systemic Inflammation

Panagiota T. Foteinou,

Affiliation Biomedical Engineering, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Steve E. Calvano,

Affiliation Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America
⨯
Stephen F. Lowry,

Affiliation Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America
⨯
Ioannis P. Androulakis

* E-mail: yannis@rci.rutgers.edu

Affiliation Biomedical Engineering, Rutgers University, Piscataway, New Jersey, United States of America
⨯

In Silico Simulation of Corticosteroids Effect on an NFkB- Dependent Physicochemical Model of Systemic Inflammation

Panagiota T. Foteinou,
Steve E. Calvano,
Stephen F. Lowry,
Ioannis P. Androulakis

Published: March 10, 2009
https://doi.org/10.1371/journal.pone.0004706

About the Authors

Panagiota T. Foteinou

Affiliation Biomedical Engineering, Rutgers University, Piscataway, New Jersey, United States of America

Steve E. Calvano

Affiliation Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America

Stephen F. Lowry

Affiliation Department of Surgery, UMDNJ-Robert Wood Johnson Medical School, New Brunswick, New Jersey, United States of America

Ioannis P. Androulakis

* E-mail: yannis@rci.rutgers.edu

Affiliation Biomedical Engineering, Rutgers University, Piscataway, New Jersey, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: IPA. Performed the experiments: PTF. Analyzed the data: PTF. Contributed reagents/materials/analysis tools: SC SL. Wrote the paper: PTF.

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Inflammation
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Endotoxins
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Transcription factors
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Cytokines
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Signal processing
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DNA transcription
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Steroids
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Transcriptional control
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