About the Authors

Delara Karkan

Contributed equally to this work with: Delara Karkan, Timothy Z. Vitalis

Current address: Centre for Evaluation of Radiopharmaceuticals and Biotherapeutics, Ottawa, Ontario, Canada,

Affiliation BioMarin Pharmaceutical Inc., Vancouver, Canada

Cheryl Pfeifer

wilf@brc.ubc.ca

Affiliations Department of Medical Genetics, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

Timothy Z. Vitalis

Contributed equally to this work with: Delara Karkan, Timothy Z. Vitalis

Current address: The Michael Smith Laboratories, University of British Columbia, Vancouver, British Columbia, Canada,

Affiliations BioMarin Pharmaceutical Inc., Vancouver, Canada, Department of Medical Genetics, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

Gavin Arthur

wilf@brc.ubc.ca

Current address: Genome British Columbia, Vancouver, British Columbia, Canada,

Affiliation BioMarin Pharmaceutical Inc., Vancouver, Canada

Maki Ujiie

wilf@brc.ubc.ca

Affiliations Department of Medical Genetics, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

Qingqi Chen

Current address: BioMarin Pharmaceutical Inc., Novato, California, United States of America,

Affiliation BioMarin Pharmaceutical Inc., Vancouver, Canada

Sam Tsai

Current address: University of Alberta, Edmonton, Alberta, Canada,

Affiliation BioMarin Pharmaceutical Inc., Vancouver, Canada

Gerrasimo Koliatis

Current address: Roche Pharmaceuticals, Nutley, New Jersey, United States of America,

Affiliations BioMarin Pharmaceutical Inc., Vancouver, Canada, Department of Medical Genetics, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

Reinhard Gabathuler

Current address: AngioChem Inc., Montreal, Quebec, Canada

Affiliations BioMarin Pharmaceutical Inc., Vancouver, Canada, Department of Medical Genetics, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

Wilfred A. Jefferies

wilf@brc.ubc.ca

Affiliations Department of Medical Genetics, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Microbiology and Immunology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada, Department of Zoology, the Michael Smith Laboratories and the Biomedical Research Centre, University of British Columbia, Vancouver, British Columbia, Canada

Competing Interests

Since submission, patents held by the authors and the University of British Columbia that are associated with the technologies described herein have been acquired by biOasis Technologies Inc.

Author Contributions

Conceived and designed the experiments: WJ DK GA MU RG TV GK. Performed the experiments: GA MU QC ST GK. Analyzed the data: WJ DK GA MU RG TV QC ST GK CP. Contributed reagents/materials/analysis tools: WJ. Wrote the paper: WJ DK GA MU TV CP.