Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function

Matthew Coussens; John G. Maresh; Ryuzo Yanagimachi; Gregg Maeda; Richard Allsopp

doi:10.1371/journal.pone.0001571

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Peer-reviewed

Research Article

Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function

Matthew Coussens,

Affiliations John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii
⨯
John G. Maresh,

Affiliation John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
⨯
Ryuzo Yanagimachi,

Affiliation John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
⨯
Gregg Maeda,

Affiliation John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii
⨯
Richard Allsopp

*E-mail: allsopp@hawaii.edu

Affiliations John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii
⨯

Sirt1 Deficiency Attenuates Spermatogenesis and Germ Cell Function

Matthew Coussens,
John G. Maresh,
Ryuzo Yanagimachi,
Gregg Maeda,
Richard Allsopp

Published: February 13, 2008
https://doi.org/10.1371/journal.pone.0001571

About the Authors

Matthew Coussens

Affiliations John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii

John G. Maresh

Affiliation John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii

Ryuzo Yanagimachi

Affiliation John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii

Gregg Maeda

Affiliation John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii

Richard Allsopp

*E-mail: allsopp@hawaii.edu

Affiliations John A. Burns School of Medicine, University of Hawaii, Honolulu, Hawaii, Institute for Biogenesis Research, University of Hawaii, Honolulu, Hawaii

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: MC JM. Performed the experiments: RY RA MC GM. Analyzed the data: RY MC. Contributed reagents/materials/analysis tools: JM. Wrote the paper: MC.

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Sperm
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Embryos
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Gene expression
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Spermatogenesis
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Oocytes
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SUMOylation
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Germ cells
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Apoptosis
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