About the Authors
- Dennis Morrison
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Affiliation Bio-Kinetic Clinical Applications, Springfield, Missouri, United States of America
- Sandip Roy
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Affiliation Novartis Exploratory Clinical Development, Cambridge, Massachusetts, and East Hanover, New Jersey, United States of America
- Craig Rayner
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Affiliation F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
- Ahmed Amer
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Affiliation Novartis Exploratory Clinical Development, Cambridge, Massachusetts, and East Hanover, New Jersey, United States of America
- Dan Howard
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Affiliation Novartis Exploratory Clinical Development, Cambridge, Massachusetts, and East Hanover, New Jersey, United States of America
- James R. Smith
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Affiliation F. Hoffmann-La Roche Ltd., Pharmaceuticals Division, Basel, Switzerland
- Thomas G. Evans
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*To whom correspondence should be addressed. E-mail: thomasg.evans@novartis.com
Affiliation Novartis Exploratory Clinical Development, Cambridge, Massachusetts, and East Hanover, New Jersey, United States of America
Competing Interests
All of the authors except D. Morrison are employees of the two companies, Roche and Novartis, that jointly financed this study.
Author Contributions
Other: Carried out and executed the study: DM AA. Analyzed the data: DM SR CR AA DH JS TE. Enrolled all the patients: DM. Carried out PK analyses: SR CR. Conceived and designed the experiments: CR DH JS TE. Contributed reagents/materials: CR. Wrote the protocol: AA. Wrote the paper: JS TE. Contributed reagents/materials/analysis tools: TE. Got Roche support: JS. Contributed reagents/materials/analysis tools, Got Novartis support: TE.