Germ Line Origin and Somatic Mutations Determine the Target Tissues in Systemic AL-Amyloidosis

Stina Enqvist; Knut Sletten; Fred J. Stevens; Ulf Hellman; Per Westermark

doi:10.1371/journal.pone.0000981

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Open Access

Peer-reviewed

Research Article

Germ Line Origin and Somatic Mutations Determine the Target Tissues in Systemic AL-Amyloidosis

Stina Enqvist,

Affiliation Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
⨯
Knut Sletten,

Affiliation Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway
⨯
Fred J. Stevens,

Affiliation Biosciences Division, Argonne National Laboratory, Argonne, Illinois, United States of America
⨯
Ulf Hellman,

Affiliation Ludwig Institute for Cancer Research, Uppsala, Sweden
⨯
Per Westermark

*To whom correspondence should be addressed. E-mail: Per.Westermark@genpat.uu.se

Affiliation Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden
⨯

Germ Line Origin and Somatic Mutations Determine the Target Tissues in Systemic AL-Amyloidosis

Stina Enqvist,
Knut Sletten,
Fred J. Stevens,
Ulf Hellman,
Per Westermark

Published: October 3, 2007
https://doi.org/10.1371/journal.pone.0000981

About the Authors

Stina Enqvist

Affiliation Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden

Knut Sletten

Affiliation Biotechnology Centre of Oslo, University of Oslo, Oslo, Norway

Fred J. Stevens

Affiliation Biosciences Division, Argonne National Laboratory, Argonne, Illinois, United States of America

Ulf Hellman

Affiliation Ludwig Institute for Cancer Research, Uppsala, Sweden

Per Westermark

*To whom correspondence should be addressed. E-mail: Per.Westermark@genpat.uu.se

Affiliation Department of Genetics and Pathology, Uppsala University, Uppsala, Sweden

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: PW SE. Performed the experiments: SE KS UH. Analyzed the data: PW KS FS UH. Contributed reagents/materials/analysis tools: PW. Wrote the paper: PW SE.

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Amyloid proteins
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Amyloidosis
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Amino acid substitution
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Antibodies
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Acid deposition
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Tissue distribution
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Protein sequencing
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Amino acid analysis
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