Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure

Biju Parekkadan; Daan van Poll; Kazuhiro Suganuma; Edward A. Carter; François Berthiaume; Arno W. Tilles; Martin L. Yarmush

doi:10.1371/journal.pone.0000941

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Peer-reviewed

Research Article

Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure

Biju Parekkadan ,

Contributed equally to this work with: Biju Parekkadan, Daan van Poll, Kazuhiro Suganuma

Affiliations Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America
⨯
Daan van Poll ,

Contributed equally to this work with: Biju Parekkadan, Daan van Poll, Kazuhiro Suganuma

Affiliations Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America, Department of Surgery, University Medical Center, University of Utrecht, Utrecht, The Netherlands
⨯
Kazuhiro Suganuma ,

Contributed equally to this work with: Biju Parekkadan, Daan van Poll, Kazuhiro Suganuma

Affiliation Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯
Edward A. Carter,

Affiliation Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯
François Berthiaume,

Affiliation Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯
Arno W. Tilles,

Affiliation Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America
⨯
Martin L. Yarmush

*To whom correspondence should be addressed. E-mail: ireis@sbi.org

Affiliations Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America
⨯

Mesenchymal Stem Cell-Derived Molecules Reverse Fulminant Hepatic Failure

Biju Parekkadan,
Daan van Poll,
Kazuhiro Suganuma,
Edward A. Carter,
François Berthiaume,
Arno W. Tilles,
Martin L. Yarmush

Published: September 26, 2007
https://doi.org/10.1371/journal.pone.0000941

About the Authors

Biju Parekkadan

Contributed equally to this work with: Biju Parekkadan, Daan van Poll, Kazuhiro Suganuma

Affiliations Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America, Harvard-Massachusetts Institute of Technology Division of Health Sciences and Technology, Cambridge, Massachusetts, United States of America

Daan van Poll

Contributed equally to this work with: Biju Parekkadan, Daan van Poll, Kazuhiro Suganuma

Affiliations Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America, Department of Surgery, University Medical Center, University of Utrecht, Utrecht, The Netherlands

Kazuhiro Suganuma

Contributed equally to this work with: Biju Parekkadan, Daan van Poll, Kazuhiro Suganuma

Affiliation Center for Engineering in Medicine and Surgical Services, Massachusetts General Hospital, Harvard Medical School and the Shriners Hospitals for Children, Boston, Massachusetts, United States of America

Edward A. Carter

François Berthiaume

Arno W. Tilles

Martin L. Yarmush

*To whom correspondence should be addressed. E-mail: ireis@sbi.org

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: BP Dv FB AT MY. Performed the experiments: BP Dv KS EC. Analyzed the data: BP Dv KS. Contributed reagents/materials/analysis tools: EC. Wrote the paper: BP MY.

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White blood cells
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Mesenchymal stem cells
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Chemokines
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Heparin
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Hepatocytes
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Stem cell therapy
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