About the Authors

Daisuke Sasaki

Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Katsuhisa Matsuura

Roles Resources, Supervision, Writing – review & editing

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Hiroyoshi Seta

Roles Resources

Affiliation Department of Cardiovascular Surgery, Tokyo Women’s Medical University, Tokyo, Japan

Yuji Haraguchi

Roles Resources

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Teruo Okano

Roles Conceptualization, Funding acquisition, Writing – review & editing

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Tatsuya Shimizu

Roles Conceptualization, Funding acquisition, Project administration, Supervision, Writing – review & editing

shimizu.tatsuya@twmu.ac.jp

Affiliation Institute of Advanced Biomedical Engineering and Science, Tokyo Women’s Medical University, Tokyo, Japan

Competing Interests

There are potential competing interests. Teruo Okano is a founder and a member of the board of CellSeed Inc. to which a cell sheet-related patent family (THERAPEUTIC SUBSTANCE DELIVERY DEVICE AND THERAPEUTIC SUBSTANCE DELIVERY KIT, WO/2017/043600) is licensed by Tokyo Women’s Medical University. Tatsuya Shimizu is a member of the scientific advisory board of CellSeed Inc. Teruo Okano and Tatsuya Shimizu are shareholders of CellSeed Inc. Tokyo Women’s Medical University receives a research fund from CellSeed Inc. for the practical application of cell sheet engineering, and a research fund from Panasonic Corporation for the establishment of noninvasive evaluation method of three-dimensional tissues. Teruo Okano, Tatsuya Shimizu, and Katsuhisa Matsuura are inventors of the bioreactor system for differentiation culture of pluripotent stem cells, the patent of which is held by Able Co. and Tokyo Women’s Medical University (CELL CULTURE APPARATUS AND CELL CULTURE METHOD USING SAME, US9574165B2). These competing interests do not alter our adherence to PLOS ONE policies on sharing data and materials.