About the Authors

Andrew L. Coppage

Affiliation Department of Developmental, Molecular and Chemical Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts, United States of America

Kathryn R. Heard

Affiliations Department of Developmental, Molecular and Chemical Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts, United States of America, Arisaph Pharmaceuticals Inc., Boston, Massachusetts, United States of America

Matthew T. DiMare

Affiliations Department of Developmental, Molecular and Chemical Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts, United States of America, Arisaph Pharmaceuticals Inc., Boston, Massachusetts, United States of America

Yuxin Liu

Affiliations Department of Developmental, Molecular and Chemical Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts, United States of America, Arisaph Pharmaceuticals Inc., Boston, Massachusetts, United States of America

Wengen Wu

Affiliations Department of Developmental, Molecular and Chemical Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts, United States of America, Arisaph Pharmaceuticals Inc., Boston, Massachusetts, United States of America

Jack H. Lai

Affiliations Department of Developmental, Molecular and Chemical Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts, United States of America, Arisaph Pharmaceuticals Inc., Boston, Massachusetts, United States of America

William W. Bachovchin

William.Bachovchin@tufts.edu

Affiliations Department of Developmental, Molecular and Chemical Biology, Tufts University Sackler School of Graduate Biomedical Sciences, Boston, Massachusetts, United States of America, Arisaph Pharmaceuticals Inc., Boston, Massachusetts, United States of America

Competing Interests

Kathryn R. Heard, Matthew T. DiMare, Yuxin Liu, Wengen Wu, Jack H. Lai and William W. Bachovchin are current or former employees of Arisaph Pharmaceuticals. William Bachovchin and Jack Lai hold stock in Arisaph Pharmaceuticals. There are no patents, products in development or marketed products to declare. This does not alter the authors' adherence to all the PLOS ONE policies on sharing data and materials, as detailed online in the guide for authors.

Author Contributions

Conceived and designed the experiments: ALC JHL WWB. Performed the experiments: ALC KRH MTD YL WW. Analyzed the data: ALC KRH MTD YL WW. Contributed reagents/materials/analysis tools: YL WW JHL WWB. Wrote the paper: ALC KRH MTD WWB.