About the Authors

Joseph Xu Zhou

Joseph.Zhou@systemsbiology.org (JZ); Sui.Huang@systemsbiology.org (SH)

Affiliations Institute for Systems Biology, Seattle, Washington, United States of America, Kavli Institute for Theoretical Physics, University of California Santa Barbara, Santa Barbara, California, United States of America, Institute for Biocomplexity and Informatics, University of Calgary, Calgary, Alberta, Canada

Angela Oliveira Pisco

Affiliations Institute for Systems Biology, Seattle, Washington, United States of America, Systems Biology Program, Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom

Hong Qian

Affiliation Department of Applied Mathematics, University of Washington, Seattle, Washington, United States of America

Sui Huang

Joseph.Zhou@systemsbiology.org (JZ); Sui.Huang@systemsbiology.org (SH)

Affiliations Institute for Systems Biology, Seattle, Washington, United States of America, Institute for Biocomplexity and Informatics, University of Calgary, Calgary, Alberta, Canada

Competing Interests

Co-author Sui Huang is a PLOS ONE Editorial Board member. This does not alter the authors' adherence to PLOS ONE Editorial policies and criteria.

Author Contributions

Conceived and designed the experiments: JZ HQ SH. Performed the experiments: JZ AOP. Analyzed the data: JZ. Contributed reagents/materials/analysis tools: HQ AOP. Wrote the paper: JZ HQ SH.