Opposite Roles for p38MAPK-Driven Responses and Reactive Oxygen Species in the Persistence and Resolution of Radiation-Induced Genomic Instability

Erica Werner; Huichen Wang; Paul W. Doetsch

doi:10.1371/journal.pone.0108234

Loading metrics

Open Access

Peer-reviewed

Research Article

Opposite Roles for p38MAPK-Driven Responses and Reactive Oxygen Species in the Persistence and Resolution of Radiation-Induced Genomic Instability

Erica Werner ,

* E-mail: medpwd@emory.edu (PWD); ewerner@emory.edu (EW)

Affiliation Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Huichen Wang,

Affiliation Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯
Paul W. Doetsch

* E-mail: medpwd@emory.edu (PWD); ewerner@emory.edu (EW)

Affiliations Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Hematology and Medical Oncology Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America
⨯

Opposite Roles for p38MAPK-Driven Responses and Reactive Oxygen Species in the Persistence and Resolution of Radiation-Induced Genomic Instability

Erica Werner,
Huichen Wang,
Paul W. Doetsch

Published: October 1, 2014
https://doi.org/10.1371/journal.pone.0108234

About the Authors

Erica Werner

* E-mail: medpwd@emory.edu (PWD); ewerner@emory.edu (EW)

Affiliation Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, United States of America

Huichen Wang

Affiliation Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America

Paul W. Doetsch

* E-mail: medpwd@emory.edu (PWD); ewerner@emory.edu (EW)

Affiliations Department of Biochemistry, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Radiation Oncology, Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America, Department of Hematology and Medical Oncology Winship Cancer Institute, Emory University School of Medicine, Atlanta, Georgia, United States of America

Competing Interests

The authors have declared that no competing interests exist.

Author Contributions

Conceived and designed the experiments: EW HW PD. Performed the experiments: EW. Analyzed the data: EW. Contributed reagents/materials/analysis tools: HW. Contributed to the writing of the manuscript: EW PD.

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Genomics
Is the Subject Area "Genomics" applicable to this article?

Thanks for your feedback.
DNA damage
Is the Subject Area "DNA damage" applicable to this article?

Thanks for your feedback.
Micronuclei
Is the Subject Area "Micronuclei" applicable to this article?

Thanks for your feedback.
Ionizing radiation
Is the Subject Area "Ionizing radiation" applicable to this article?

Thanks for your feedback.
Radiation therapy
Is the Subject Area "Radiation therapy" applicable to this article?

Thanks for your feedback.
DNA repair
Is the Subject Area "DNA repair" applicable to this article?

Thanks for your feedback.
Cellular stress responses
Is the Subject Area "Cellular stress responses" applicable to this article?

Thanks for your feedback.
Radiobiology
Is the Subject Area "Radiobiology" applicable to this article?

Thanks for your feedback.