About the Authors

Manish Sadarangani

manish.sadarangani@paediatrics.ox.ac.uk

Affiliations Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom, Division of Infectious Diseases, Department of Pediatrics, University of British Columbia and BC Children's Hospital, Vancouver, British Columbia, Canada

J. Claire Hoe

Affiliation Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Martin J. Callaghan

Affiliation Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Claire Jones

Affiliation Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Hannah Chan

Affiliation Division of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom

Katherine Makepeace

Affiliation Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Hélène Daniels-Treffandier

Affiliation Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Mary E. Deadman

Affiliation Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Christopher Bayliss

Affiliation Department of Genetics, University of Leicester, Leicester, United Kingdom

Ian Feavers

Affiliation Division of Bacteriology, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, United Kingdom

Peter van der Ley

Affiliation Department of Vaccinology, National Institute of Public Health and the Environment (RIVM), Bilthoven, The Netherlands

Andrew J. Pollard

Affiliation Department of Paediatrics, University of Oxford and the NIHR Oxford Biomedical Research Centre, Oxford, United Kingdom

Competing Interests

AJP and IF are named inventors on Opa related patents (0428381.8, dated 24/12/2004 and WO2006/067469 A2, dated 22/12/2005). AJP is an advisor to the UK Department of Health's Joint Committee on Vaccines and Immunisation on meningococcal vaccines. AJP conducts clinical trials of meningococcal vaccines on behalf of the University of Oxford and his department has received unrestricted educational grants from vaccine manufacturers (Novartis, GlaxoSmithKline, Pfizer and Sanofi Pasteur) for organisation of educational activities, but he receives no personal payments from them. This does not alter the authors′ adherence to all the PLOS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: MS JCH MJC CJ MED CB PvdL AJP. Performed the experiments: MS JCH CJ HC KM HDT MED CB. Analyzed the data: MS. Contributed reagents/materials/analysis tools: MS JCH CJ HC MED CB IF PvdL. Wrote the paper: MS.