About the Authors

Noah M. Walton

noah.walton@us.astellas.com

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Rick Shin

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Katsunori Tajinda

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Carrie L. Heusner

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Jeffrey H. Kogan

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Shinichi Miyake

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Qian Chen

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Kouichi Tamura

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Mitsuyuki Matsumoto

Affiliation CNS, Astellas Research Institute of America LLC, Skokie, Illinois, United States of America

Competing Interests

All authors are employees of Astellas Pharmacuticals, a drug company. This does not alter the authors’ adherence to all the PLoS ONE policies on sharing data and materials.

Author Contributions

Conceived and designed the experiments: NW K. Tajinda MM. Performed the experiments: NW RS K. Tajinda. Analyzed the data: NW MM RS JK CH K. Tamura QC SM. Contributed reagents/materials/analysis tools: K. Tamura MM. Wrote the paper: NW MM.