September 2021

The genus Bothrops is the major cause of snake envenomations in the state of Mato Grosso do Sul in Brazil. In the photo there is an example of B. moojeni, an abundant species in Central Brazil. Ceron, et al. (2021)

Image Credit: Diego J. Santana, Universidade Federal de Mato Grosso do Sul

Editorial

Multiphase evaluation of portable medicines quality screening devices

Céline Caillet, Serena Vickers, Stephen Zambrzycki, Nantasit Luangasanatip, Vayouly Vidhamaly, Kem Boutsamay, Phonepasith Boupha, Yoel Lubell, Facundo M. Fernández, Paul N. Newton

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009287

Viewpoints

The wider societal benefits of surgical interventions for lymphatic filariasis morbidity management and disability prevention

Sarah Martindale, John Chiphwanya, Dorothy Emmie Matipula, Paul Ndhlovu, Hannah Betts, Louise A. Kelly-Hope

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009701

Policy Platform

A framework for scabies control

Daniel Engelman, Michael Marks, Andrew C. Steer, Abate Beshah, Gautam Biswas, Olivier Chosidow, Luc E. Coffeng, Belen Lardizabal Dofitas, Wendemagegn Enbiale, Mosoka Fallah, Elkhan Gasimov, Adrian Hopkins, Julie Jacobson, John M. Kaldor, Fatimata Ly, Charles D. Mackenzie, Jodie McVernon, Matthew Parnaby, Merelesita Rainima-Qaniuci, Oliver Sokana, Dieudonne Sankara, Rie Yotsu, Aya Yajima, Paul T. Cantey

PLOS Neglected Tropical Diseases: published September 2, 2021 | https://doi.org/10.1371/journal.pntd.0009661

Reviews

The role of urbanisation in the spread of Aedes mosquitoes and the diseases they transmit—A systematic review

Antonios Kolimenakis, Sabine Heinz, Michael Lowery Wilson, Volker Winkler, Laith Yakob, Antonios Michaelakis, Dimitrios Papachristos, Clive Richardson, Olaf Horstick

PLOS Neglected Tropical Diseases: published September 9, 2021 | https://doi.org/10.1371/journal.pntd.0009631

The impact of access to water supply and sanitation on the prevalence of active trachoma in Ethiopia: A systematic review and meta-analysis

Thomas Ayalew Abebe, Gudina Terefe Tucho

PLOS Neglected Tropical Diseases: published September 9, 2021 | https://doi.org/10.1371/journal.pntd.0009644

A proposed framework for the development and qualitative evaluation of West Nile virus models and their application to local public health decision-making

Alexander C. Keyel, Morgan E. Gorris, Ilia Rochlin, Johnny A. Uelmen, Luis F. Chaves, Gabriel L. Hamer, Imelda K. Moise, Marta Shocket, A. Marm Kilpatrick, Nicholas B. DeFelice, Justin K. Davis, Eliza Little, Patrick Irwin, Andrew J. Tyre, Kelly Helm Smith, Chris L. Fredregill, Oliver Elison Timm, Karen M. Holcomb, Michael C. Wimberly, Matthew J. Ward, Christopher M. Barker, Charlotte G. Rhodes, Rebecca L. Smith

PLOS Neglected Tropical Diseases: published September 9, 2021 | https://doi.org/10.1371/journal.pntd.0009653

Early warning systems (EWSs) for chikungunya, dengue, malaria, yellow fever, and Zika outbreaks: What is the evidence? A scoping review

Laith Hussain-Alkhateeb, Tatiana Rivera Ramírez, Axel Kroeger, Ernesto Gozzer, Silvia Runge-Ranzinger

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009686

Blocking HTLV-1/2 silent transmission in Brazil: Current public health policies and proposal for additional strategies

Carolina Rosadas, Maria Luiza B. Menezes, Bernardo Galvão-Castro, Tatiane Assone, Angélica E. Miranda, Mayra G. Aragón, Adele Caterino-de-Araujo, Graham P. Taylor, Ricardo Ishak

PLOS Neglected Tropical Diseases: published September 23, 2021 | https://doi.org/10.1371/journal.pntd.0009717

Scabies in remote Aboriginal and Torres Strait Islander populations in Australia: A narrative review

Prudence Gramp, Dallas Gramp

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009751

Research Articles

Ocurrence of rotavirus and picobirnavirus in wild and exotic avian from amazon forest

José Wandilson Barboza Duarte Júnior, Elaine Hellen Nunes Chagas, Ana Carolina Silva Serra, Lizandra Caroline dos Santos Souto, Edvaldo Tavares da Penha Júnior, Renato da Silva Bandeira, Ricardo José de Paula Souza e Guimarães, Hanna Gabriela da Silva Oliveira, Thaymis Kiara Santos Sousa, Cinthia Távora de Albuquerque Lopes, Sheyla Farhayldes Souza Domingues, Helder Henrique Costa Pinheiro, Yashpal Singh Malik, Felipe Masiero Salvarani, Joana D’Arc Pereira Mascarenhas

PLOS Neglected Tropical Diseases: published September 10, 2021 | https://doi.org/10.1371/journal.pntd.0008792

PIWI silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with Schistosoma mansoni in the snail vector, Biomphalaria glabrata

Michael Smith, Swara Yadav, Olayemi G. Fagunloye, Nana Adjoa Pels, Daniel A. Horton, Nashwah Alsultan, Andrea Borns, Carolyn Cousin, Freddie Dixon, Victoria H. Mann, Clarence Lee, Paul J. Brindley, Najib M. El-Sayed, Joanna M. Bridger, Matty Knight

PLOS Neglected Tropical Diseases: published September 8, 2021 | https://doi.org/10.1371/journal.pntd.0009094

Laboratory evaluation of twelve portable devices for medicine quality screening

Stephen C. Zambrzycki, Celine Caillet, Serena Vickers, Marcos Bouza, David V. Donndelinger, Laura C. Geben, Matthew C. Bernier, Paul N. Newton, Facundo M. Fernández

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009360

Developmental changes and metabolic reprogramming during establishment of infection and progression of Trypanosoma brucei brucei through its insect host

Arunasalam Naguleswaran, Paula Fernandes, Shubha Bevkal, Ruth Rehmann, Pamela Nicholson, Isabel Roditi

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009504

Implementation of field detection devices for antimalarial quality screening in Lao PDR—A cost-effectiveness analysis

Nantasit Luangasanatip, Panarasri Khonputsa, Céline Caillet, Serena Vickers, Stephen Zambrzycki, Facundo M. Fernández, Paul N. Newton, Yoel Lubell

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009539

Assessing factors influencing communities’ acceptability of mass drug administration for the elimination of lymphatic filariasis in Guyana

Reza A. Niles, Charles R. Thickstun, Horace Cox, Daniel Dilliott, Clara R. Burgert-Brucker, Emma M. Harding-Esch, Nikita Clementson, Annastacia Sampson, Jean Seme Alexandre, Ana C. Morice Trejos, Ronaldo G. Carvalho Scholte, Alison Krentel

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009596

Cholera outbreak in Forcibly Displaced Myanmar National (FDMN) from a small population segment in Cox’s Bazar, Bangladesh, 2019

Abu S. G. Faruque, Azharul Islam Khan, Baitun Nahar, S. M. Rafiqul Islam, M. Nasif Hossain, Syed Asif Abdullah, Soroar Hossain Khan, Md. Sabbir Hossain, Feroz Hayat Khan, Mukeshkumar Prajapati, Yulia Widiati, A. S. M. Mainul Hasan, Minjoon Kim, Jennie Musto, Maya Vandenent, John David Clemens, Tahmeed Ahmed

PLOS Neglected Tropical Diseases: published September 22, 2021 | https://doi.org/10.1371/journal.pntd.0009618

Evidence for hidden leprosy in a high leprosy-endemic setting, Eastern Ethiopia: The application of active case-finding and contact screening

Kedir Urgesa, Kidist Bobosha, Berhanu Seyoum, Fitsum Weldegebreal, Adane Mihret, Rawleigh Howe, Biftu Geda, Mirgissa Kaba, Abraham Aseffa

PLOS Neglected Tropical Diseases: published September 2, 2021 | https://doi.org/10.1371/journal.pntd.0009640

Trends in the prevalence of microscopically-confirmed schistosomiasis in the South African public health sector, 2011–2018

Liesl De Boni, Veerle Msimang, Alex De Voux, John Frean

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009669

A comparative field evaluation of six medicine quality screening devices in Laos

Céline Caillet, Serena Vickers, Stephen Zambrzycki, Facundo M. Fernández, Vayouly Vidhamaly, Kem Boutsamay, Phonepasith Boupha, Pimnara Peerawaranun, Mavuto Mukaka, Paul N. Newton

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009674

Mobile microscopy and telemedicine platform assisted by deep learning for the quantification of Trichuris trichiura infection

Elena Dacal, David Bermejo-Peláez, Lin Lin, Elisa Álamo, Daniel Cuadrado, Álvaro Martínez, Adriana Mousa, María Postigo, Alicia Soto, Endre Sukosd, Alexander Vladimirov, Charles Mwandawiro, Paul Gichuki, Nana Aba Williams, José Muñoz, Stella Kepha, Miguel Luengo-Oroz

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009677

A dengue outbreak in a rural community in Northern Coastal Ecuador: An analysis using unmanned aerial vehicle mapping

Gwenyth O. Lee, Luis Vasco, Sully Márquez, Julio C. Zuniga-Moya, Amanda Van Engen, Jessica Uruchima, Patricio Ponce, William Cevallos, Gabriel Trueba, James Trostle, Veronica J. Berrocal, Amy C. Morrison, Varsovia Cevallos, Carlos Mena, Josefina Coloma, Joseph N. S. Eisenberg

PLOS Neglected Tropical Diseases: published September 27, 2021 | https://doi.org/10.1371/journal.pntd.0009679

Loss of binding antibodies against rabies in a vaccinated dog population in Flores Island, Indonesia

Ewaldus Wera, Charlotte Warembourg, Petrus M. Bulu, Maria M. Siko, Salome Dürr

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009688

Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi

Leroy Versteeg, Rakesh Adhikari, Cristina Poveda, Maria Jose Villar-Mondragon, Kathryn M. Jones, Peter J. Hotez, Maria Elena Bottazzi, Edwin Tijhaar, Jeroen Pollet

PLOS Neglected Tropical Diseases: published September 3, 2021 | https://doi.org/10.1371/journal.pntd.0009689

Dynamics of G6PD activity in patients receiving weekly primaquine for therapy of Plasmodium vivax malaria

Walter R. J. Taylor, Saorin Kim, Sim Kheng, Sinoun Muth, Pety Tor, Eva Christophel, Mavuto Mukaka, Alexandra Kerleguer, Lucio Luzzatto, J. Kevin Baird, Didier Menard

PLOS Neglected Tropical Diseases: published September 8, 2021 | https://doi.org/10.1371/journal.pntd.0009690

Aedes albopictus bionomics data collection by citizen participation on Procida Island, a promising Mediterranean site for the assessment of innovative and community-based integrated pest management methods

Beniamino Caputo, Giuliano Langella, Valeria Petrella, Chiara Virgillito, Mattia Manica, Federico Filipponi, Marianna Varone, Pasquale Primo, Arianna Puggioli, Romeo Bellini, Costantino D’Antonio, Luca Iesu, Liliana Tullo, Ciro Rizzo, Annalisa Longobardi, Germano Sollazzo, Maryanna Martina Perrotta, Miriana Fabozzi, Fabiana Palmieri, Giuseppe Saccone, Roberto Rosà, Alessandra della Torre, Marco Salvemini

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009698

Long-term neurological and healthcare burden of adults with Japanese encephalitis: A nationwide study 2000-2015

Hsuan-Ying Chen, Chen-Yi Yang, Cheng-Yang Hsieh, Chun-Yin Yeh, Chang-Chun Chen, Yen-Chin Chen, Chung-Chih Lai, Rebecca Claire Harris, Huang-Tz Ou, Nai-Ying Ko, Wen-Chien Ko

PLOS Neglected Tropical Diseases: published September 14, 2021 | https://doi.org/10.1371/journal.pntd.0009703

Comparative clinical characteristics and outcomes of patients with community acquired bacteremia caused by Escherichia coli, Burkholderia pseudomallei and Staphylococcus aureus: A prospective observational study (Ubon-sepsis)

Ranjani Somayaji, Viriya Hantrakun, Prapit Teparrukkul, Gumphol Wongsuvan, Kristina E. Rudd, Nicholas P. J. Day, T. Eoin West, Direk Limmathurotsakul

PLOS Neglected Tropical Diseases: published September 3, 2021 | https://doi.org/10.1371/journal.pntd.0009704

Metabolomics reveal alterations in arachidonic acid metabolism in Schistosoma mekongi after exposure to praziquantel

Peerut Chienwichai, Phornpimon Tipthara, Joel Tarning, Yanin Limpanont, Phiraphol Chusongsang, Yupa Chusongsang, Poom Adisakwattana, Onrapak Reamtong

PLOS Neglected Tropical Diseases: published September 2, 2021 | https://doi.org/10.1371/journal.pntd.0009706

Urinary genome detection and tracking of Hantaan virus from hemorrhagic fever with renal syndrome patients using multiplex PCR-based next-generation sequencing

Seungchan Cho, Won-Keun Kim, Jin Sun No, Seung-Ho Lee, Jaehun Jung, Yongjin Yi, Hayne Cho Park, Geum-Young Lee, Kyungmin Park, Jeong-Ah Kim, Jongwoo Kim, Jingyeong Lee, Daesang Lee, Dong Hyun Song, Se Hun Gu, Seong Tae Jeong, Jin-Won Song

PLOS Neglected Tropical Diseases: published September 28, 2021 | https://doi.org/10.1371/journal.pntd.0009707

Prevalence of diarrhoeal pathogens among children under five years of age with and without diarrhoea in Guinea-Bissau

Sointu Mero, Suvi Timonen, Tinja Lääveri, Sandra Løfberg, Juha Kirveskari, Johan Ursing, Lars Rombo, Poul-Erik Kofoed, Anu Kantele

PLOS Neglected Tropical Diseases: published September 29, 2021 | https://doi.org/10.1371/journal.pntd.0009709

Schistosome infection in Senegal is associated with different spatial extents of risk and ecological drivers for Schistosoma haematobium and S. mansoni

Isabel J. Jones, Susanne H. Sokolow, Andrew J. Chamberlin, Andrea J. Lund, Nicolas Jouanard, Lydie Bandagny, Raphaël Ndione, Simon Senghor, Anne-Marie Schacht, Gilles Riveau, Skylar R. Hopkins, Jason R. Rohr, Justin V. Remais, Kevin D. Lafferty, Armand M. Kuris, Chelsea L. Wood, Giulio De Leo

PLOS Neglected Tropical Diseases: published September 27, 2021 | https://doi.org/10.1371/journal.pntd.0009712

Involvement of von Willebrand factor and botrocetin in the thrombocytopenia induced by Bothrops jararaca snake venom

Camila Martos Thomazini, Ana Teresa Azevedo Sachetto, Cynthia Zaccanini de Albuquerque, Vânia Gomes de Moura Mattaraia, Ana Karina de Oliveira, Solange Maria de Toledo Serrano, Ivo Lebrun, Katia Cristina Barbaro, Marcelo Larami Santoro

PLOS Neglected Tropical Diseases: published September 3, 2021 | https://doi.org/10.1371/journal.pntd.0009715

Vibrio cholerae O139 persists in Dhaka, Bangladesh since 1993

Irin Parvin, Abu Sadat Mohammad Sayeem Bin Shahid, Subhasish Das, Lubaba Shahrin, Mst. Mahmuda Ackhter, Tahmina Alam, Soroar Hossain Khan, Mohammod Jobayer Chisti, John D. Clemens, Tahmeed Ahmed, David A. Sack, Abu Syed Golam Faruque

PLOS Neglected Tropical Diseases: published September 2, 2021 | https://doi.org/10.1371/journal.pntd.0009721

MALDI-TOF mass spectrometry for the identification of freshwater snails from Senegal, including intermediate hosts of schistosomes

Fatima Zohra Hamlili, Fatou Thiam, Maureen Laroche, Adama Zan Diarra, Souleymane Doucouré, Papa Mouhamadou Gaye, Cheikh Binetou Fall, Babacar Faye, Cheikh Sokhna, Doudou Sow, Philippe Parola

PLOS Neglected Tropical Diseases: published September 13, 2021 | https://doi.org/10.1371/journal.pntd.0009725

Implementing trachoma control programmes in marginalised populations in Tanzania: A qualitative study exploring the experiences and perspectives of key stakeholders

Kaki Tsang, Gilles de Wildt, Upendo Mwingira, Tara B. Mtuy

PLOS Neglected Tropical Diseases: published September 10, 2021 | https://doi.org/10.1371/journal.pntd.0009727

Trypanosoma cruzi infection follow-up in a sylvatic vector of Chagas disease: Comparing early and late stage nymphs

Valeria Cortés, Amalia Cruz, Sofia Onetti, Daniela Kinzel, Javiera Garcia, Sylvia Ortiz, Angélica Lopez, Pedro E. Cattan, Carezza Botto-Mahan, Aldo Solari

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009729

Characterisation of novel functionality within the Blastocystis tryptophanase gene

Steven Santino Leonardi, Feng-Jun Li, Melissa Su-Juan Chee, John Anthony Yason, Hui Yi Tay, John Yu-Shen Chen, Eileen Yiling Koh, Cynthia Ying-Xin He, Kevin Shyong-Wei Tan

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009730

How beliefs in traditional healers impact on the use of allopathic medicine: In the case of indigenous snakebite in Eswatini

Sarah Nann

PLOS Neglected Tropical Diseases: published September 9, 2021 | https://doi.org/10.1371/journal.pntd.0009731

An old drug and different ways to treat cutaneous leishmaniasis: Intralesional and intramuscular meglumine antimoniate in a reference center, Rio de Janeiro, Brazil

Carla Oliveira-Ribeiro, Maria Inês Fernandes Pimentel, Liliane de Fátima Antonio Oliveira, Érica de Camargo Ferreira e Vasconcellos, Fatima Conceição-Silva, Armando de Oliveira Schubach, Aline Fagundes, Cintia Xavier de Mello, Eliame Mouta-Confort, Luciana de Freitas Campos Miranda, Claudia Maria Valete-Rosalino, Ana Cristina da Costa Martins, Raquel de Vasconcellos Carvalhaes de Oliveira, Leonardo Pereira Quintella, Marcelo Rosandiski Lyra

PLOS Neglected Tropical Diseases: published September 23, 2021 | https://doi.org/10.1371/journal.pntd.0009734

Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs

Ana Amélia Nunes Santos, Priscyla dos Santos Ribeiro, Geórgia Virgínia da França, Fábio Neves Souza, Eduardo Antônio Gonçalves Ramos, Cláudio Pereira Figueira, Mitermayer G. Reis, Federico Costa, Paula Ristow

PLOS Neglected Tropical Diseases: published September 8, 2021 | https://doi.org/10.1371/journal.pntd.0009736

Epidemiology of snake envenomation from Mato Grosso do Sul, Brazil

Karoline Ceron, Cássia Vieira, Priscila Santos Carvalho, Juan Fernando Cuestas Carrillo, Jaqueline Alonso, Diego José Santana

PLOS Neglected Tropical Diseases: published September 8, 2021 | https://doi.org/10.1371/journal.pntd.0009737

In vitro culture of freshly isolated Trypanosoma brucei brucei bloodstream forms results in gene copy-number changes

Julius Mulindwa, Geofrey Ssentamu, Enock Matovu, Kevin Kamanyi Marucha, Francisco Aresta-Branco, Claudia Helbig, Christine Clayton

PLOS Neglected Tropical Diseases: published September 13, 2021 | https://doi.org/10.1371/journal.pntd.0009738

Trypanosome SL-RNA detection in blood and cerebrospinal fluid to demonstrate active gambiense human African trypanosomiasis infection

Ipos Ngay Lukusa, Nick Van Reet, Dieudonné Mumba Ngoyi, Erick Mwamba Miaka, Justin Masumu, Pati Patient Pyana, Wilfried Mutombo, Digas Ngolo, Vincent Kobo, Felix Akwaso, Médard Ilunga, Lewis Kaninda, Sylvain Mutanda, Dieudonné Mpoyi Muamba, Olaf Valverde Mordt, Antoine Tarral, Sandra Rembry, Philippe Büscher, Veerle Lejon

PLOS Neglected Tropical Diseases: published September 17, 2021 | https://doi.org/10.1371/journal.pntd.0009739

Assessment of the required performance and the development of corresponding program decision rules for neglected tropical diseases diagnostic tests: Monitoring and evaluation of soil-transmitted helminthiasis control programs as a case study

Bruno Levecke, Luc E. Coffeng, Christopher Hanna, Rachel L. Pullan, Katherine M. Gass

PLOS Neglected Tropical Diseases: published September 14, 2021 | https://doi.org/10.1371/journal.pntd.0009740

Association of comorbidity between Opisthorchis viverrini infection and diabetes mellitus in the development of cholangiocarcinoma among a high-risk population, northeastern Thailand

Kavin Thinkhamrop, Narong Khuntikeo, Wongsa Laohasiriwong, Pornpimon Chupanit, Matthew Kelly, Apiporn T. Suwannatrai

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009741

Human leishmaniasis vaccines: Use cases, target population and potential global demand

Stefano Malvolti, Melissa Malhame, Carsten F. Mantel, Epke A. Le Rutte, Paul M. Kaye

PLOS Neglected Tropical Diseases: published September 21, 2021 | https://doi.org/10.1371/journal.pntd.0009742

Longitudinal analysis of human humoral responses after vaccination with a live attenuated V. cholerae vaccine

Oluwaseyi Adekunle, Alexandra Dretler, Robert C. Kauffman, Alice Cho, Nadine Rouphael, Jens Wrammert

PLOS Neglected Tropical Diseases: published September 3, 2021 | https://doi.org/10.1371/journal.pntd.0009743

Surveillance for peri-elimination trachoma recrudescence: Exploratory studies in Ghana

Laura Senyonjo, James Addy, Diana L. Martin, David Agyemang, Dorothy Yeboah-Manu, Sarah Gwyn, Benjamin Marfo, Adwoa Asante-Poku, Agatha Aboe, Ernest Mensah, Anthony W. Solomon, Robin L. Bailey

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009744

Increasingly expanded future risk of dengue fever in the Pearl River Delta, China

Wei Wu, Hongyan Ren, Liang Lu

PLOS Neglected Tropical Diseases: published September 24, 2021 | https://doi.org/10.1371/journal.pntd.0009745

Insecticide resistance in Aedes aegypti from Tapachula, Mexico: Spatial variation and response to historical insecticide use

Francisco Solis-Santoyo, Americo D. Rodriguez, R. Patricia Penilla-Navarro, Daniel Sanchez, Alfredo Castillo-Vera, Alma D. Lopez-Solis, Eduardo D. Vazquez-Lopez, Saul Lozano, William C. Black IV, Karla Saavedra-Rodriguez

PLOS Neglected Tropical Diseases: published September 27, 2021 | https://doi.org/10.1371/journal.pntd.0009746

Leptospirosis in pregnancy: A systematic review

Sujitha Selvarajah, Shaolu Ran, Nia Wyn Roberts, Manisha Nair

PLOS Neglected Tropical Diseases: published September 14, 2021 | https://doi.org/10.1371/journal.pntd.0009747

Prevalence and relevant factors of positive RF in brucellosis patients with arthralgia

Siwen Zhang, Jing Hu, Shuqi An, Mujinyan Li, Fande Li, Peng Zhang, Xiangyi Zhang, Huixin Yang, Taijun Wang, Jingjing Luo, Fangfang Hu, Jiashuo Liu, Qing Zhen

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009749

Assessment of fitness and vector competence of a New Caledonia wMel Aedes aegypti strain before field-release

Nicolas Pocquet, Olivia O’Connor, Heather A. Flores, Jordan Tutagata, Morgane Pol, David J. Hooker, Catherine Inizan, Sylvie Russet, Johanna M. Duyvestyn, Etiene C. Pacidônio, Dominique Girault, Daniela da Silva Gonçalves, Marine Minier, Frédéric Touzain, Elodie Chalus, Kevin Lucien, Florie Cheilan, Tristan Derycke, Sylvie Laumond, Cameron P. Simmons, Myrielle Dupont-Rouzeyrol, Nadège Rossi

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009752

Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure

Michelle J. Lin, Austin M. Haynes, Amin Addetia, Nicole A. P. Lieberman, Quynh Phung, Hong Xie, Tien V. Nguyen, Barbara J. Molini, Sheila A. Lukehart, Lorenzo Giacani, Alexander L. Greninger

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009753

A genomic snapshot of Salmonella enterica serovar Typhi in Colombia

Paula Diaz Guevara, Mailis Maes, Duy Pham Thanh, Carolina Duarte, Edna Catering Rodriguez, Lucy Angeline Montaño, Thanh Ho Ngoc Dan, To Nguyen Thi Nguyen, Megan E. Carey, Josefina Campos, Isabel Chinen, Enrique Perez, Stephen Baker

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009755

Intestinal schistosomiasis among schoolchildren in Sana’a Governorate, Yemen: Prevalence, associated factors and its effect on nutritional status and anemia

Sami Ahmed Al-Haidari, Mohammed A. K. Mahdy, Abdulsalam M. Al-Mekhlafi, Walid M. S. Al Murisi, Ahmed Ali Qaid Thabit, Mohammed Abdullah Al-Amad, Hassan Al-Shamahi, Othman Saeed Bahashwan, Abdulwahed Al Serouri

PLOS Neglected Tropical Diseases: published September 21, 2021 | https://doi.org/10.1371/journal.pntd.0009757

Snakebites in “Invisible Populations”: A cross-sectional survey in riverine populations in the remote western Brazilian Amazon

Guilherme Kemeron Maciel Salazar, Joseir Saturnino Cristino, Alexandre Vilhena Silva-Neto, Altair Seabra Farias, João Arthur Alcântara, Vinícius Azevedo Machado, Felipe Murta, Vanderson Souza Sampaio, Fernando Val, André Sachett, Paulo Sérgio Bernarde, Marcus Lacerda, Fan Hui Wen, Wuelton Monteiro, Jacqueline Sachett

PLOS Neglected Tropical Diseases: published September 9, 2021 | https://doi.org/10.1371/journal.pntd.0009758

The increased presence of repetitive motifs in the KDDR-plus recombinant protein, a kinesin-derived antigen from Leishmania infantum, improves the diagnostic performance of serological tests for human and canine visceral leishmaniasis

Williane Fernanda Siqueira, Agostinho Gonçalves Viana, João Luís Reis Cunha, Leticia Mansur Rosa, Lilian Lacerda Bueno, Daniella Castanheira Bartholomeu, Mariana Santos Cardoso, Ricardo Toshio Fujiwara

PLOS Neglected Tropical Diseases: published September 17, 2021 | https://doi.org/10.1371/journal.pntd.0009759

VPS38/UVRAG and ATG14, the variant regulatory subunits of the ATG6/Beclin1-PI3K complexes, are crucial for the biogenesis of the yolk organelles and are transcriptionally regulated in the oocytes of the vector Rhodnius prolixus

Priscila H. Vieira, Claudia F. Benjamim, Georgia Atella, Isabela Ramos

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009760

Epidemiology of clinically relevant Entamoeba spp. (E. histolytica/dispar/moshkovskii/bangladeshi): A cross sectional study from North India

Aradhana Singh, Tuhina Banerjee, Uzma Khan, Sunit Kumar Shukla

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009762

Assessment of the diagnostic accuracy and relevance of a novel ELISA system developed for seroepidemiologic surveys of Helicobacter pylori infection in African settings

Evariste Tshibangu-Kabamba, Bui Hoang Phuc, Vo Phuoc Tuan, Kartika Afrida Fauzia, Augustin Kabongo-Tshibaka, Nadine Kalenda Kayiba, Angel Rosas-Aguirre, Brecht Devleesschauwer, Alain Cimuanga-Mukanya, Patrick de Jésus Ngoma Kisoko, Takashi Matsumoto, Junko Akada, Ghislain Tumba Disashi, Dieudonné Mumba Ngoyi, Yasutoshi Kido, Niko Speybroeck, Yoshio Yamaoka

PLOS Neglected Tropical Diseases: published September 9, 2021 | https://doi.org/10.1371/journal.pntd.0009763

Role of T cells during the cerebral infection with Trypanosoma brucei

Gabriela C. Olivera, Leonie Vetter, Chiara Tesoriero, Federico Del Gallo, Gustav Hedberg, Juan Basile, Martin E. Rottenberg

PLOS Neglected Tropical Diseases: published September 29, 2021 | https://doi.org/10.1371/journal.pntd.0009764

Real-time PCR assay for detection and differentiation of Coccidioides immitis and Coccidioides posadasii from culture and clinical specimens

Sudha Chaturvedi, Tanya R. Victor, Anuradha Marathe, Ketevan Sidamonidze, Kelly L. Crucillo, Vishnu Chaturvedi

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009765

Multiple vector-borne pathogens of domestic animals in Egypt

Hend H. A. M. Abdullah, Nadia Amanzougaghene, Handi Dahmana, Meriem Louni, Didier Raoult, Oleg Mediannikov

PLOS Neglected Tropical Diseases: published September 29, 2021 | https://doi.org/10.1371/journal.pntd.0009767

Attenuated infection by a Pteropine orthoreovirus isolated from an Egyptian fruit bat in Zambia

Hayato Harima, Michihito Sasaki, Yasuko Orba, Kosuke Okuya, Yongjin Qiu, Christida E. Wastika, Katendi Changula, Masahiro Kajihara, Edgar Simulundu, Tomoyuki Yamaguchi, Yoshiki Eto, Akina Mori-Kajihara, Akihiko Sato, Satoshi Taniguchi, Ayato Takada, Masayuki Saijo, Bernard M. Hang’ombe, Hirofumi Sawa

PLOS Neglected Tropical Diseases: published September 7, 2021 | https://doi.org/10.1371/journal.pntd.0009768

Measuring endemicity and burden of leprosy across countries and regions: A systematic review and Delphi survey

Dorcas O. Ogunsumi, Vivek Lal, Karl Philipp Puchner, Wim van Brakel, Eva-Maria Schwienhorst-Stich, Christa Kasang, Joseph Chukwu, Saskia Kreibich, Sandra Parisi, Jan Hendrik Richardus, David J. Blok

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009769

The association between tropical cyclones and dengue fever in the Pearl River Delta, China during 2013-2018: A time-stratified case-crossover study

Chuanxi Li, Qi Zhao, Zhe Zhao, Qiyong Liu, Wei Ma

PLOS Neglected Tropical Diseases: published September 9, 2021 | https://doi.org/10.1371/journal.pntd.0009776

Characterization of the β-tubulin gene family in Ascaris lumbricoides and Ascaris suum and its implication for the molecular detection of benzimidazole resistance

Sara Roose, Russell W. Avramenko, Stephen M. J. Pollo, James D. Wasmuth, Shaali Ame, Mio Ayana, Martha Betson, Piet Cools, Daniel Dana, Ben P. Jones, Zeleke Mekonnen, Arianna Morosetti, Abhinaya Venkatesan, Johnny Vlaminck, Matthew L. Workentine, Bruno Levecke, John S. Gilleard, Peter Geldhof

PLOS Neglected Tropical Diseases: published September 27, 2021 | https://doi.org/10.1371/journal.pntd.0009777

Exploring barriers for trachomatous trichiasis surgery implementation in gamo zone, Southern Ethiopia

Chuchu Churko, Mekuria Asnakew Asfaw, Zerihun Zerdo

PLOS Neglected Tropical Diseases: published September 15, 2021 | https://doi.org/10.1371/journal.pntd.0009780

Plasmodium vivax epidemiology in Ethiopia 2000-2020: A systematic review and meta-analysis

Tsige Ketema, Ketema Bacha, Kefelegn Getahun, Hernando A. del Portillo, Quique Bassat

PLOS Neglected Tropical Diseases: published September 15, 2021 | https://doi.org/10.1371/journal.pntd.0009781

Sensitive and semiquantitative detection of soil-transmitted helminth infection in stool using a recombinase polymerase amplification-based assay

Jason L. Cantera, Heather N. White, Matthew S. Forrest, Oliver W. Stringer, Vicente Y. Belizario Jr, Helen L. Storey, Eugenio L. de Hostos, Tala de los Santos

PLOS Neglected Tropical Diseases: published September 13, 2021 | https://doi.org/10.1371/journal.pntd.0009782

Rift Valley fever virus 78kDa envelope protein attenuates virus replication in macrophage-derived cell lines and viral virulence in mice

Kaori Terasaki, Birte Kalveram, Kendra N. Johnson, Terry Juelich, Jennifer K. Smith, Lihong Zhang, Alexander N. Freiberg, Shinji Makino

PLOS Neglected Tropical Diseases: published September 13, 2021 | https://doi.org/10.1371/journal.pntd.0009785

Evaluating livestock farmers knowledge, beliefs, and management of arboviral diseases in Kenya: A multivariate fractional probit approach

Paul Nyamweya Nyangau, Jonathan Makau Nzuma, Patrick Irungu, Menale Kassie

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009786

Clinical characterization of Lassa fever: A systematic review of clinical reports and research to inform clinical trial design

Laura Merson, Josephine Bourner, Sulaiman Jalloh, Astrid Erber, Alex Paddy Salam, Antoine Flahault, Piero L. Olliaro

PLOS Neglected Tropical Diseases: published September 21, 2021 | https://doi.org/10.1371/journal.pntd.0009788

“We know about schistosomiasis but we know nothing about FGS”: A qualitative assessment of knowledge gaps about female genital schistosomiasis among communities living in Schistosoma haematobium endemic districts of Zanzibar and Northwestern Tanzania

Humphrey D. Mazigo, Anna Samson, Valencia J. Lambert, Agnes L. Kosia, Deogratias D. Ngoma, Rachel Murphy, Dunstan J. Matungwa

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009789

Assessment of neuropathic pain in leprosy patients with relapse or treatment failure by infrared thermography: A cross-sectional study

Liliane Marques de Pinho Tiago, Diogo Fernandes dos Santos, Douglas Eulálio Antunes, Letícia Marques Pinho Tiago, Isabela Maria Bernardes Goulart

PLOS Neglected Tropical Diseases: published September 23, 2021 | https://doi.org/10.1371/journal.pntd.0009794

Variants of MIRNA146A rs2910164 and MIRNA499 rs3746444 are associated with the development of cutaneous leishmaniasis caused by Leishmania guyanensis and with plasma chemokine IL-8

Tirza Gabrielle Ramos de Mesquita, José do Espírito Santo Junior, Thais Carneiro de Lacerda, Krys Layane Guimarães Duarte Queiroz, Cláudio Marcello da Silveira Júnior, José Pereira de Moura Neto, Lissianne Augusta Matos Gomes, Mara Lúcia Gomes de Souza, Marcus Vinitius de Farias Guerra, Rajendranath Ramasawmy

PLOS Neglected Tropical Diseases: published September 20, 2021 | https://doi.org/10.1371/journal.pntd.0009795

High prevalence of Schistosoma japonicum by perfusion in naturally exposed water buffalo in a region of the Philippines endemic for human schistosomiasis

Mario Jiz, Claro Mingala, Zhi-Qiang Fu, Melika Adriatico, Ke Lu, Blanca Jarilla, Marianne Sagliba, Ammabelle Moreno, Sangshin Park, Jiao-Jiao Lin, Remigio Olveda, Jonathan D. Kurtis, Hannah W. Wu

PLOS Neglected Tropical Diseases: published September 16, 2021 | https://doi.org/10.1371/journal.pntd.0009796

A gene expression panel for estimating age in males and females of the sleeping sickness vector Glossina morsitans

Eric R. Lucas, Alistair C. Darby, Stephen J. Torr, Martin J. Donnelly

PLOS Neglected Tropical Diseases: published September 23, 2021 | https://doi.org/10.1371/journal.pntd.0009797

Dengue and Chikungunya virus co-infection in major metropolitan cities of provinces of Punjab and Khyber Pakhtunkhwa: A multi-center study

Faiz Ahmed Raza, Hasnain Javed, Muhammad Mujeeb Khan, Obaid Ullah, Areeba Fatima, Muhammad Zaheer, Saima Mohsin, Shahida Hasnain, Ruqyya Khalid, Arslan Ahmed Salam

PLOS Neglected Tropical Diseases: published September 23, 2021 | https://doi.org/10.1371/journal.pntd.0009802

Implementation of mass drug administration for neglected tropical diseases in Guinea during the COVID-19 pandemic

Fatoumata Sakho, Christelly Flore Badila, Benoit Dembele, Aissatou Diaby, Abdoul Karim Camara, Lamine Lamah, Steven D. Reid, Angel Weng, Brian B. Fuller, Katherine A. Sanchez, Achille Kabore, Yaobi Zhang, Angela Weaver

PLOS Neglected Tropical Diseases: published September 27, 2021 | https://doi.org/10.1371/journal.pntd.0009807

Clinical profile and mortality in patients with T. cruzi/HIV co-infection from the multicenter data base of the “Network for healthcare and study of Trypanosoma cruzi/HIV co-infection and other immunosuppression conditions”

Maria Aparecida Shikanai-Yasuda, Mauro Felippe Felix Mediano, Christina Terra Gallafrio Novaes, Andréa Silvestre de Sousa, Ana Marli Christovam Sartori, Rodrigo Carvalho Santana, Dalmo Correia, Cleudson Nery de Castro, Marilia Maria dos Santos Severo, Alejandro Marcel Hasslocher-Moreno, Marisa Liliana Fernandez, Fernando Salvador, Maria Jesús Pinazo, Valdes Roberto Bolella, Pedro Carvalho Furtado, Marcelo Corti, Ana Yecê Neves Pinto, Alberto Fica, Israel Molina, Joaquim Gascon, Pedro Albajar Viñas, Juan Cortez-Escalante, Alberto Novaes Ramos Jr, Eros Antonio de Almeida

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009809

The role of nuclear organization in trans-splicing based expression of heat shock protein 90 in Giardia lamblia

Vinithra Iyer, Sheetal Tushir, Shreekant Verma, Sudeshna Majumdar, Srimonta Gayen, Rakesh Mishra, Utpal Tatu

PLOS Neglected Tropical Diseases: published September 24, 2021 | https://doi.org/10.1371/journal.pntd.0009810

Hypoxic and nitrosative stress conditions modulate expression of myoglobin genes in a carcinogenic hepatobiliary trematode, Clonorchis sinensis

Seon-Hee Kim, Dongki Yang, Young-An Bae

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009811

Morphological, molecular and MALDI-TOF MS identification of ticks and tick-associated pathogens in Vietnam

Ly Na Huynh, Adama Zan Diarra, Quang Luan Pham, Nhiem Le-Viet, Jean-Michel Berenger, Van Hoang Ho, Xuan Quang Nguyen, Philippe Parola

PLOS Neglected Tropical Diseases: published September 28, 2021 | https://doi.org/10.1371/journal.pntd.0009813

Autoimmunity to phosphatidylserine and anemia in African Trypanosome infections

Juan Rivera-Correa, Joseph Verdi, Julian Sherman, Jeremy M. Sternberg, Jayne Raper, Ana Rodriguez

PLOS Neglected Tropical Diseases: published September 29, 2021 | https://doi.org/10.1371/journal.pntd.0009814

The impact of mating and sugar feeding on blood-feeding physiology and behavior in the arbovirus vector mosquito Aedes aegypti

Garrett P. League, Ethan C. Degner, Sylvie A. Pitcher, Yassi Hafezi, Erica Tennant, Priscilla C. Cruz, Raksha S. Krishnan, Stefano S. Garcia Castillo, Catalina Alfonso-Parra, Frank W. Avila, Mariana F. Wolfner, Laura C. Harrington

PLOS Neglected Tropical Diseases: published September 30, 2021 | https://doi.org/10.1371/journal.pntd.0009815

Leishmania tarentolae and Leishmania infantum in humans, dogs and cats in the Pelagie archipelago, southern Italy

Roberta Iatta, Jairo Alfonso Mendoza-Roldan, Maria Stefania Latrofa, Antonio Cascio, Emanuele Brianti, Marco Pombi, Simona Gabrielli, Domenico Otranto

PLOS Neglected Tropical Diseases: published September 23, 2021 | https://doi.org/10.1371/journal.pntd.0009817

Mining nematode protein secretomes to explain lifestyle and host specificity

Lucienne Tritten, Cristina Ballesteros, Robin Beech, Timothy G. Geary, Yovany Moreno

PLOS Neglected Tropical Diseases: published September 29, 2021 | https://doi.org/10.1371/journal.pntd.0009828

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**Brazilian lancehead (Bothrops moojeni)**