Advertisement
Table of Contents

April 2020

Cover

The Plasma Mobile, ‘A gift from heaven’: the impact of health technology transfer on trial perceptions and expectations during the Ebola-Tx Trial, Conakry
Issue Image

The 'Plasma Mobile', equipped with plasmapheresis and pathogen inactivation technologies, was parked at the National Blood Transfusion Centre in Conakry, Guinea, where the convalescent plasma donation was set up. Convalescent plasma was used as an experimental therapy for Ebola Virus Disease in the Ebola-Tx trial. Mari Saez, et al. (2020)

Image Credit: Picture by Maya Ronse, Copyright Institute of Tropical Medicine Antwerp, 2020

Editorial

Will COVID-19 become the next neglected tropical disease?

Peter J. Hotez, Maria E. Bottazzi, Sunit K. Singh, Paul J. Brindley, Shaden Kamhawi

PLOS Neglected Tropical Diseases: published April 10, 2020 | https://doi.org/10.1371/journal.pntd.0008271

Viewpoints

Target product profile for a test for the early assessment of treatment efficacy in Chagas disease patients: An expert consensus

Julio Alonso-Padilla, Marcelo Abril, Belkisyolé Alarcón de Noya, Igor C. Almeida, Andrea Angheben, Tania Araujo Jorge, Eric Chatelain, Monica Esteva, Joaquim Gascón, Mario J. Grijalva, Felipe Guhl, Alejandro Marcel Hasslocher-Moreno, Manuel Carlos López, Alejandro Luquetti, Oscar Noya, María Jesús Pinazo, Janine M. Ramsey, Isabela Ribeiro, Andres Mariano Ruiz, Alejandro G. Schijman, Sergio Sosa-Estani, M. Carmen Thomas, Faustino Torrico, Maan Zrein, Albert Picado

PLOS Neglected Tropical Diseases: published April 23, 2020 | https://doi.org/10.1371/journal.pntd.0008035

Policy Platform

Modelling for policy: The five principles of the Neglected Tropical Diseases Modelling Consortium

Matthew R. Behrend, María-Gloria Basáñez, Jonathan I. D. Hamley, Travis C. Porco, Wilma A. Stolk, Martin Walker, Sake J. de Vlas, for the NTD Modelling Consortium

PLOS Neglected Tropical Diseases: published April 9, 2020 | https://doi.org/10.1371/journal.pntd.0008033

Reviews

Schistosome migration in the definitive host

Catherine S. Nation, Akram A. Da’dara, Jeffrey K. Marchant, Patrick J. Skelly

PLOS Neglected Tropical Diseases: published April 2, 2020 | https://doi.org/10.1371/journal.pntd.0007951

Host immune responses during Taenia solium Neurocysticercosis infection and treatment

Ulrich Fabien Prodjinotho, Jakobo Lema, Matthew Lacorcia, Veronika Schmidt, Nermina Vejzagic, Chummy Sikasunge, Bernard Ngowi, Andrea Sylvia Winkler, Clarissa Prazeres da Costa

PLOS Neglected Tropical Diseases: published April 16, 2020 | https://doi.org/10.1371/journal.pntd.0008005

Host genetic susceptibility to mycetoma

Rayan S. Ali, Melanie J. Newport, Sahar Mubarak Bakhiet, Muntaser E. Ibrahim, Ahmed Hassan Fahal

PLOS Neglected Tropical Diseases: published April 30, 2020 | https://doi.org/10.1371/journal.pntd.0008053

Research Articles

Deciphering the possible role of ctxB7 allele on higher production of cholera toxin by Haitian variant Vibrio cholerae O1

Arindam Naha, Rahul Shubhra Mandal, Prosenjit Samanta, Rudra Narayan Saha, Sreeja Shaw, Amit Ghosh, Nabendu Sekhar Chatterjee, Pujarini Dutta, Keinosuke Okamoto, Shanta Dutta, Asish Kumar Mukhopadhyay

PLOS Neglected Tropical Diseases: published April 1, 2020 | https://doi.org/10.1371/journal.pntd.0008128

A novel cystatin derived from Trichinella spiralis suppresses macrophage-mediated inflammatory responses

Porntida Kobpornchai, Robin J. Flynn, Onrapak Reamtong, Nonglucksanawan Rittisoonthorn, Nathamon Kosoltanapiwat, Kobporn Boonnak, Usa Boonyuen, Sumate Ampawong, Montakan Jiratanh, Muncharee Tattiyapong, Poom Adisakwattana

PLOS Neglected Tropical Diseases: published April 1, 2020 | https://doi.org/10.1371/journal.pntd.0008192

High throughput screening and identification of coagulopathic snake venom proteins and peptides using nanofractionation and proteomics approaches

Julien Slagboom, Marija Mladić, Chunfang Xie, Taline D. Kazandjian, Freek Vonk, Govert W. Somsen, Nicholas R. Casewell, Jeroen Kool

PLOS Neglected Tropical Diseases: published April 1, 2020 | https://doi.org/10.1371/journal.pntd.0007802

Risk factors for acute human brucellosis in Ijara, north-eastern Kenya

Stella G. Kiambi, Eric M. Fèvre, Jared Omolo, Joseph Oundo, William A. de Glanville

PLOS Neglected Tropical Diseases: published April 1, 2020 | https://doi.org/10.1371/journal.pntd.0008108

Adding MASP1 to the lectin pathway—Leprosy association puzzle: Hints from gene polymorphisms and protein levels

Hellen Weinschutz Mendes, Angelica Beate Winter Boldt, Ewalda von Rosen Seeling Stahlke, Jens Christian Jensenius, Steffen Thiel, Iara J. Taborda Messias-Reason

PLOS Neglected Tropical Diseases: published April 2, 2020 | https://doi.org/10.1371/journal.pntd.0007534

Non-typhoidal Salmonella bloodstream infections in Kisantu, DR Congo: Emergence of O5-negative Salmonella Typhimurium and extensive drug resistance

Bieke Tack, Marie-France Phoba, Barbara Barbé, Lisette M. Kalonji, Liselotte Hardy, Sandra Van Puyvelde, Brecht Ingelbeen, Dadi Falay, Dauly Ngonda, Marianne A. B. van der Sande, Stijn Deborggraeve, Jan Jacobs, Octavie Lunguya

PLOS Neglected Tropical Diseases: published April 2, 2020 | https://doi.org/10.1371/journal.pntd.0008121

In vivo imaging of transgenic Brugia malayi

Canhui Liu, Sai Lata De, Kristi Miley, Thomas R. Unnasch

PLOS Neglected Tropical Diseases: published April 3, 2020 | https://doi.org/10.1371/journal.pntd.0008182

Immunomodulatory dynamics of excretory and secretory products on Th9 immune response during Haemonchus contortus infection in goat

Muhammad Ali Memon, Muhammad Ali-ul-Husnain Naqvi, Huang Xin, Liang Meng, Muhammad Waqqas Hasan, Muhammad Haseeb, Shakeel Ahmed Lakho, Kalilixiati Aimulajiang, Yongqian Bu, Lixin Xu, Xiaokai Song, Xiangrui Li, Ruofeng Yan

PLOS Neglected Tropical Diseases: published April 3, 2020 | https://doi.org/10.1371/journal.pntd.0008218

Urticaria and silent parasitism by Ascaridoidea: Component-resolved diagnosis reinforces the significance of this association

Marta Viñas, Idoia Postigo, Ester Suñén, Jorge Martínez

PLOS Neglected Tropical Diseases: published April 3, 2020 | https://doi.org/10.1371/journal.pntd.0008177

Persistent deleterious effects of a deleterious Wolbachia infection

Perran A. Ross, Jason K. Axford, Ashley G. Callahan, Kelly M. Richardson, Ary A. Hoffmann

PLOS Neglected Tropical Diseases: published April 3, 2020 | https://doi.org/10.1371/journal.pntd.0008204

Cell-mediated and serology-based tests for Mycobacterium ulcerans disease: A systematic review and meta-analysis

Michael S. Avumegah, Nilakshi T. Waidyatillake, Wojtek P. Michalski, Daniel P. O’Brien, Tiffanie M. Nelson, Eugene Athan

PLOS Neglected Tropical Diseases: published April 6, 2020 | https://doi.org/10.1371/journal.pntd.0008172

Risk prediction of two types of potential snail habitats in Anhui Province of China: Model-based approaches

Jun Zhang, Ming Yue, Yi Hu, Robert Bergquist, Chuan Su, Fenghua Gao, Zhi-Guo Cao, Zhijie Zhang

PLOS Neglected Tropical Diseases: published April 6, 2020 | https://doi.org/10.1371/journal.pntd.0008178

Comparative genomics and full-length Tprk profiling of Treponema pallidum subsp. pallidum reinfection

Amin Addetia, Lauren C. Tantalo, Michelle J. Lin, Hong Xie, Meei-Li Huang, Christina M. Marra, Alexander L. Greninger

PLOS Neglected Tropical Diseases: published April 6, 2020 | https://doi.org/10.1371/journal.pntd.0007921

Performance evaluation of a prototype rapid diagnostic test for combined detection of gambiense human African trypanosomiasis and malaria

Crispin Lumbala, Enock Matovu, Hakim Sendagire, Anne J. N. Kazibwe, Joris L. Likwela, Hypolite Muhindo Mavoko, Simon Kayembe, Pascal Lutumba, Sylvain Biéler, Jean-Pierre Van Geertruyden, Joseph M. Ndung’u

PLOS Neglected Tropical Diseases: published April 6, 2020 | https://doi.org/10.1371/journal.pntd.0008168

Understanding the role of disease knowledge and risk perception in shaping preventive behavior for selected vector-borne diseases in Guyana

Céline Aerts, Mélanie Revilla, Laetitia Duval, Krijn Paaijmans, Javin Chandrabose, Horace Cox, Elisa Sicuri

PLOS Neglected Tropical Diseases: published April 6, 2020 | https://doi.org/10.1371/journal.pntd.0008149

Dual RNA-Seq characterization of host and pathogen gene expression in liver cells infected with Crimean-Congo Hemorrhagic Fever Virus

Robert A. Kozak, Russell S. Fraser, Mia J. Biondi, Anna Majer, Sarah J. Medina, Bryan D. Griffin, Darwyn Kobasa, Patrick J. Stapleton, Chantel Urfano, Giorgi Babuadze, Kym Antonation, Lisa Fernando, Stephanie Booth, Brandon N. Lillie, Gary P. Kobinger

PLOS Neglected Tropical Diseases: published April 6, 2020 | https://doi.org/10.1371/journal.pntd.0008105

Lemongrass (Cymbopogon citratus) oil: A promising miticidal and ovicidal agent against Sarcoptes scabiei

Meilin Li, Buming Liu, Charlotte Bernigaud, Katja Fischer, Jacques Guillot, Fang Fang

PLOS Neglected Tropical Diseases: published April 6, 2020 | https://doi.org/10.1371/journal.pntd.0008225

Predicting disease risk areas through co-production of spatial models: The example of Kyasanur Forest Disease in India’s forest landscapes

Bethan V. Purse, Narayanaswamy Darshan, Gudadappa S. Kasabi, France Gerard, Abhishek Samrat, Charles George, Abi T. Vanak, Meera Oommen, Mujeeb Rahman, Sarah J. Burthe, Juliette C. Young, Prashanth N. Srinivas, Stefanie M. Schäfer, Peter A. Henrys, Vijay K. Sandhya, M Mudassar Chanda, Manoj V. Murhekar, Subhash L. Hoti, Shivani K. Kiran

PLOS Neglected Tropical Diseases: published April 7, 2020 | https://doi.org/10.1371/journal.pntd.0008179

Spatial-temporal characteristics of severe fever with thrombocytopenia syndrome and the relationship with meteorological factors from 2011 to 2018 in Zhejiang Province, China

Haocheng Wu, Chen Wu, Qinbao Lu, Zheyuan Ding, Ming Xue, Junfen Lin

PLOS Neglected Tropical Diseases: published April 7, 2020 | https://doi.org/10.1371/journal.pntd.0008186

Evidence of the absence of human African trypanosomiasis in two northern districts of Uganda: Analyses of cattle, pigs and tsetse flies for the presence of Trypanosoma brucei gambiense

Lucas J. Cunningham, Jessica K. Lingley, Iñaki Tirados, Johan Esterhuizen, Mercy Opiyo, Clement T. N. Mangwiro, Mike J. Lehane, Stephen J. Torr

PLOS Neglected Tropical Diseases: published April 7, 2020 | https://doi.org/10.1371/journal.pntd.0007737

Diagnostic value of the molecular detection of Sarcoptes scabiei from a skin scraping in patients with suspected scabies

Moonsuk Bae, Ji Yeun Kim, Jiwon Jung, Hye Hee Cha, Na-Young Jeon, Hyun-Jung Lee, Min Jae Kim, Sung Eun Chang, Sung-Han Kim

PLOS Neglected Tropical Diseases: published April 7, 2020 | https://doi.org/10.1371/journal.pntd.0008229

Proteomic analysis of the processes leading to Madurella mycetomatis grain formation in Galleria mellonella larvae

Gerard Sheehan, Mickey Konings, Wilson Lim, Ahmed Fahal, Kevin Kavanagh, Wendy W. J. van de Sande

PLOS Neglected Tropical Diseases: published April 8, 2020 | https://doi.org/10.1371/journal.pntd.0008190

Route of inoculation and mosquito vector exposure modulate dengue virus replication kinetics and immune responses in rhesus macaques

Michael K. McCracken, Gregory D. Gromowski, Lindsey S. Garver, Brad A. Goupil, Kathryne D. Walker, Heather Friberg, Jeffrey R. Currier, Wiriya Rutvisuttinunt, Kevin L. Hinton, Rebecca C. Christofferson, Christopher N. Mores, Yannick Vanloubbeeck, Clarisse Lorin, Marie-Pierre Malice, Stephen J. Thomas, Richard G. Jarman, David W. Vaughn, J. Robert Putnak, Lucile Warter

PLOS Neglected Tropical Diseases: published April 8, 2020 | https://doi.org/10.1371/journal.pntd.0008191

Individual and clinical variables associated with the risk of Buruli ulcer acquisition: A systematic review and meta-analysis

João Fevereiro, Nikta Sajjadi, Alexandra G. Fraga, Pedro M. Teixeira, Jorge Pedrosa

PLOS Neglected Tropical Diseases: published April 8, 2020 | https://doi.org/10.1371/journal.pntd.0008161

Environmental and spatial determinants of enteric pathogen infection in rural Lao People’s Democratic Republic: A cross-sectional study

Anna N. Chard, Karen Levy, Kelly K. Baker, Kevin Tsai, Howard H. Chang, Vonethalom Thongpaseuth, Jeticia R. Sistrunk, Matthew C. Freeman

PLOS Neglected Tropical Diseases: published April 8, 2020 | https://doi.org/10.1371/journal.pntd.0008180

Field evaluation of DNA detection of human filarial and malaria parasites using mosquito excreta/feces

Corrado Minetti, Nils Pilotte, Michael Zulch, Tiago Canelas, Edward J. Tettevi, Francis B. D. Veriegh, Mike Yaw Osei-Atweneboana, Steven A. Williams, Lisa J. Reimer

PLOS Neglected Tropical Diseases: published April 8, 2020 | https://doi.org/10.1371/journal.pntd.0008175

One mean to rule them all? The arithmetic mean based egg reduction rate can be misleading when estimating anthelminthic drug efficacy in clinical trials

Wendelin Moser, Jennifer Keiser, Benjamin Speich, Somphou Sayasone, Stefanie Knopp, Jan Hattendorf

PLOS Neglected Tropical Diseases: published April 8, 2020 | https://doi.org/10.1371/journal.pntd.0008185

Molecular and epidemiological analysis of a Burkholderia cepacia sepsis outbreak from a tertiary care hospital in Bangladesh

Refath Farzana, Lim S. Jones, Md. Anisur Rahman, Kirsty Sands, Edward Portal, Ian Boostrom, Md. Abul Kalam, Brekhna Hasan, Afifah Khan, Timothy R. Walsh

PLOS Neglected Tropical Diseases: published April 9, 2020 | https://doi.org/10.1371/journal.pntd.0008200

Epigenetic regulation of defense genes by histone deacetylase1 in human cell line-derived macrophages promotes intracellular survival of Leishmania donovani

Gargi Roy, Harsimran Kaur Brar, Rohini Muthuswami, Rentala Madhubala

PLOS Neglected Tropical Diseases: published April 10, 2020 | https://doi.org/10.1371/journal.pntd.0008167

The impact of insecticide treated curtains on dengue virus transmission: A cluster randomized trial in Iquitos, Peru

Audrey Lenhart, Amy C. Morrison, Valerie A. Paz-Soldan, Brett M. Forshey, Jhonny J. Cordova-Lopez, Helvio Astete, John P. Elder, Moises Sihuincha, Esther E. Gotlieb, Eric S. Halsey, Tadeusz J. Kochel, Thomas W. Scott, Neal Alexander, Philip J. McCall

PLOS Neglected Tropical Diseases: published April 10, 2020 | https://doi.org/10.1371/journal.pntd.0008097

Increases in [IP3]i aggravates diastolic [Ca2+] and contractile dysfunction in Chagas’ human cardiomyocytes

Alfredo Mijares, Raúl Espinosa, José Adams, José R. Lopez

PLOS Neglected Tropical Diseases: published April 10, 2020 | https://doi.org/10.1371/journal.pntd.0008162

Elucidating the possible mechanism of action of some pathogen box compounds against Leishmania donovani

Wandayi Emmanuel Amlabu, Christine Achiaa Antwi, Gordon Awandare, Theresa Manful Gwira

PLOS Neglected Tropical Diseases: published April 10, 2020 | https://doi.org/10.1371/journal.pntd.0008188

Understanding risk communication for prevention and control of vector-borne diseases: A mixed-method study in Curaçao

Vaitiare Mulderij-Jansen, Jelte Elsinga, Izzy Gerstenbluth, Ashley Duits, Adriana Tami, Ajay Bailey

PLOS Neglected Tropical Diseases: published April 13, 2020 | https://doi.org/10.1371/journal.pntd.0008136

The invasive Asian bush mosquito Aedes japonicus found in the Netherlands can experimentally transmit Zika virus and Usutu virus

Sandra R. Abbo, Tessa M. Visser, Haidong Wang, Giel P. Göertz, Jelke J. Fros, Marleen H. C. Abma-Henkens, Corinne Geertsema, Chantal B. F. Vogels, Marion P. G. Koopmans, Chantal B. E. M. Reusken, Sonja Hall-Mendelin, Roy A. Hall, Monique M. van Oers, Constantianus J. M. Koenraadt, Gorben P. Pijlman

PLOS Neglected Tropical Diseases: published April 13, 2020 | https://doi.org/10.1371/journal.pntd.0008217

Evaluation of copromicroscopy and serology to measure the exposure to Ascaris infections across age groups and to assess the impact of 3 years of biannual mass drug administration in Jimma Town, Ethiopia

Daniel Dana, Johnny Vlaminck, Mio Ayana, Bamlaku Tadege, Zeleke Mekonnen, Peter Geldhof, Bruno Levecke

PLOS Neglected Tropical Diseases: published April 13, 2020 | https://doi.org/10.1371/journal.pntd.0008037

The Strongyloides stercoralis-hookworms association as a path to the estimation of the global burden of strongyloidiasis: A systematic review

Pedro E. Fleitas, Marina Travacio, Helena Martí-Soler, M. Eugenia Socías, Walter R. Lopez, Alejandro J. Krolewiecki

PLOS Neglected Tropical Diseases: published April 13, 2020 | https://doi.org/10.1371/journal.pntd.0008184

Comprehensive characterization of plasma cell-free Echinococcus spp. DNA in echinococcosis patients using ultra-high-throughput sequencing

Jingkai Ji, Bin Li, Jingzhong Li, Wangmu Danzeng, Jiandong Li, Yanping Zhao, Gezhen Qiangba, Qingda Zhang, Nibu Renzhen, Zhuoga Basang, Changlin Jia, Quzhen Gongsang, Jinmin Ma, Yicong Wang, Fang Chen, Hongcheng Zhou, Huasang, Jiefang Yin, Jiandan Xie, Na Pei, Huimin Cai, Huayan Jiang, Huanming Yang, Jian Wang, Asan, Xiumin Han, Junhua Li, Weijun Chen, Dong Yang

PLOS Neglected Tropical Diseases: published April 13, 2020 | https://doi.org/10.1371/journal.pntd.0008148

Potency and breadth of human primary ZIKV immune sera shows that Zika viruses cluster antigenically as a single serotype

Chad D. Nix, Jonathan Salberg, Felicity J. Coulter, Bettie W. Kareko, Zoe L. Lyski, Brian L. Booty, William B. Messer

PLOS Neglected Tropical Diseases: published April 13, 2020 | https://doi.org/10.1371/journal.pntd.0008006

The estimated burden of scrub typhus in Thailand from national surveillance data (2003-2018)

Tri Wangrangsimakul, Ivo Elliott, Supalert Nedsuwan, Rawadee Kumlert, Soawapak Hinjoy, Kittipong Chaisiri, Nicholas P. J. Day, Serge Morand

PLOS Neglected Tropical Diseases: published April 14, 2020 | https://doi.org/10.1371/journal.pntd.0008233

Vector competence of Aedes aegypti, Aedes albopictus, and Culex quinquefasciatus mosquitoes for Mayaro virus

Thiago Nunes Pereira, Fabiano Duarte Carvalho, Silvana Faria De Mendonça, Marcele Neves Rocha, Luciano Andrade Moreira

PLOS Neglected Tropical Diseases: published April 14, 2020 | https://doi.org/10.1371/journal.pntd.0007518

Persistence of Brucella abortus lineages revealed by genomic characterization and phylodynamic analysis

Marcela Suárez-Esquivel, Gabriela Hernández-Mora, Nazareth Ruiz-Villalobos, Elías Barquero-Calvo, Carlos Chacón-Díaz, Jason T. Ladner, Gerardo Oviedo-Sánchez, Jeffrey T. Foster, Norman Rojas-Campos, Esteban Chaves-Olarte, Nicholas R. Thomson, Edgardo Moreno, Caterina Guzmán-Verri

PLOS Neglected Tropical Diseases: published April 14, 2020 | https://doi.org/10.1371/journal.pntd.0008235

Identification of cholera hotspots in Zambia: A spatiotemporal analysis of cholera data from 2008 to 2017

John Mwaba, Amanda K. Debes, Patrick Shea, Victor Mukonka, Orbrie Chewe, Caroline Chisenga, Michelo Simuyandi, Geoffrey Kwenda, David Sack, Roma Chilengi, Mohammad Ali

PLOS Neglected Tropical Diseases: published April 15, 2020 | https://doi.org/10.1371/journal.pntd.0008227

Praziquantel and risk of visual disorders: Case series assessment

Merhawi Debesai, Mulugeta Russom

PLOS Neglected Tropical Diseases: published April 15, 2020 | https://doi.org/10.1371/journal.pntd.0008198

Evolution of kdr haplotypes in worldwide populations of Aedes aegypti: Independent origins of the F1534C kdr mutation

Luciano Veiga Cosme, Andrea Gloria-Soria, Adalgisa Caccone, Jeffrey Robert Powell, Ademir Jesus Martins

PLOS Neglected Tropical Diseases: published April 16, 2020 | https://doi.org/10.1371/journal.pntd.0008219

Evidence for both sequential mutations and recombination in the evolution of kdr alleles in Aedes aegypti

Yinjun Fan, Patrick O'Grady, Melissa Yoshimizu, Alongkot Ponlawat, Phillip E. Kaufman, Jeffrey G. Scott

PLOS Neglected Tropical Diseases: published April 17, 2020 | https://doi.org/10.1371/journal.pntd.0008154

Gender norms and mass deworming program access in Comé, Benin: A qualitative assessment of gender-associated opportunities and challenges to achieving high mass drug administration coverage

Rachel E. Geyer, Moudachirou Ibikounlé, Mira Emmanuel-Fabula, Amy Roll, Euripide Avokpaho, Abiguel Elijan, Léopold Codjo Wèkè, Comlanvi Innocent Togbevi, Félicien Chabi, Parfait Houngbégnon, Adrian J. F. Luty, Elodie Yard, Judd L. Walson, Susan Graham, Arianna Rubin Means

PLOS Neglected Tropical Diseases: published April 17, 2020 | https://doi.org/10.1371/journal.pntd.0008153

Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection

Gurdip Singh Mann, Amanda F. Francisco, Shiromani Jayawardhana, Martin C. Taylor, Michael D. Lewis, Francisco Olmo, Elisangela Oliveira de Freitas, Fabiana M. S. Leoratti, Cesar López-Camacho, Arturo Reyes-Sandoval, John M. Kelly

PLOS Neglected Tropical Diseases: published April 17, 2020 | https://doi.org/10.1371/journal.pntd.0007717

Click chemistry-facilitated comprehensive identification of proteins adducted by antimicrobial 5-nitroimidazoles for discovery of alternative drug targets against giardiasis

Tineke Lauwaet, Yukiko Miyamoto, Sozaburo Ihara, Christine Le, Jarosław Kalisiak, Keith A. Korthals, Majid Ghassemian, Diane K. Smith, K. Barry Sharpless, Valery V. Fokin, Lars Eckmann

PLOS Neglected Tropical Diseases: published April 17, 2020 | https://doi.org/10.1371/journal.pntd.0008224

Human vascular endothelial cells express epithelial growth factor in response to infection by Bartonella bacilliformis

Linda D. Hicks, Michael F. Minnick

PLOS Neglected Tropical Diseases: published April 17, 2020 | https://doi.org/10.1371/journal.pntd.0008236

Stable establishment of wMel Wolbachia in Aedes aegypti populations in Yogyakarta, Indonesia

Warsito Tantowijoyo, Bekti Andari, Eggi Arguni, Nida Budiwati, Indah Nurhayati, Iva Fitriana, Inggrid Ernesia, Edwin W. Daniwijaya, Endah Supriyati, Dedik H. Yusdiana, Munasdi Victorius, Dwi S. Wardana, Hilmi Ardiansyah, Riris Andono Ahmad, Peter A. Ryan, Cameron P. Simmons, Ary A. Hoffmann, Edwige Rancès, Andrew P. Turley, Petrina Johnson, Adi Utarini, Scott L. O’Neill

PLOS Neglected Tropical Diseases: published April 17, 2020 | https://doi.org/10.1371/journal.pntd.0008157

Ecology of domestic dogs Canis familiaris as an emerging reservoir of Guinea worm Dracunculus medinensis infection

Robbie A. McDonald, Jared K. Wilson-Aggarwal, George J. F. Swan, Cecily E. D. Goodwin, Tchonfienet Moundai, Dieudonné Sankara, Gautam Biswas, James A. Zingeser

PLOS Neglected Tropical Diseases: published April 20, 2020 | https://doi.org/10.1371/journal.pntd.0008170

Distribution and seasonal fluctuations of Ae. aegypti and Ae. albopictus larval and pupae in residential areas in an urban landscape

Jayanthi Rajarethinam, Janet Ong, Zhi-Wei Neo, Lee-Ching Ng, Joel Aik

PLOS Neglected Tropical Diseases: published April 20, 2020 | https://doi.org/10.1371/journal.pntd.0008209

Genomic analysis of pathogenic isolates of Vibrio cholerae from eastern Democratic Republic of the Congo (2014-2017)

Leonid M. Irenge, Jérôme Ambroise, Prudence N. Mitangala, Bertrand Bearzatto, Raphaël K. S. Kabangwa, Jean-François Durant, Jean-Luc Gala

PLOS Neglected Tropical Diseases: published April 20, 2020 | https://doi.org/10.1371/journal.pntd.0007642

Does skin surface temperature variation account for Buruli ulcer lesion distribution?

Nicola K. Sexton-Oates, Andrew J. Stewardson, Arvind Yerramilli, Paul D. R. Johnson

PLOS Neglected Tropical Diseases: published April 20, 2020 | https://doi.org/10.1371/journal.pntd.0007732

Genomic analysis of natural intra-specific hybrids among Ethiopian isolates of Leishmania donovani

James A. Cotton, Caroline Durrant, Susanne U. Franssen, Tesfaye Gelanew, Asrat Hailu, David Mateus, Mandy J. Sanders, Matthew Berriman, Petr Volf, Michael A. Miles, Matthew Yeo

PLOS Neglected Tropical Diseases: published April 20, 2020 | https://doi.org/10.1371/journal.pntd.0007143

Implementer and recipient perspectives of community-wide mass drug administration for soil-transmitted helminths in Kwale County, Kenya

Hugo Legge, Stella Kepha, Mateo Prochazka, Katherine Halliday, Rachel Pullan, Marie-Claire Gwayi-Chore, Doris Njomo

PLOS Neglected Tropical Diseases: published April 20, 2020 | https://doi.org/10.1371/journal.pntd.0008258

Molecular epidemiology of dengue fever outbreaks in Bhutan, 2016-2017

Sangay Zangmo, Jit Bdr Darnal, Tsheten, Sonam Gyeltshen, Binay Thapa Thapa, Prinyada Rodpradit, Piyawan Chinnawirotpisan, Wudtichai Manasatienkij, Louis R. Macareo, Stefan Fernandez, Sonam Wangchuk, Chonticha Klungthong

PLOS Neglected Tropical Diseases: published April 22, 2020 | https://doi.org/10.1371/journal.pntd.0008165

The Plasma Mobile, ‘A gift from heaven’: The impact of health technology transfer on trial perceptions and expectations during the Ebola-Tx Trial, Conakry

Almudena Marí Sáez, Maya Ronse, Alexandre Delamou, Nyankoye Haba, Frédéric Bigey, Johan van Griensven, Koen Peeters Grietens

PLOS Neglected Tropical Diseases: published April 22, 2020 | https://doi.org/10.1371/journal.pntd.0008206

Intestinal protozoan infections among children 0-168 months with diarrhea in Mozambique: June 2014 - January 2018

Adilson Fernando Loforte Bauhofer, Idalécia Cossa-Moiane, Selma Marques, Esperança L. Guimarães, Benilde Munlela, Elda Anapakala, Jorfélia J. Chilaúle, Marta Cassocera, Jerónimo S. Langa, Assucênio Chissaque, Júlia Sambo, Lena Manhique-Coutinho, Diocreciano Matias Bero, Timothy A. Kellogg, Nilsa de Deus

PLOS Neglected Tropical Diseases: published April 22, 2020 | https://doi.org/10.1371/journal.pntd.0008195

Study of Usutu virus neuropathogenicity in mice and human cellular models

Marion Clé, Jonathan Barthelemy, Caroline Desmetz, Vincent Foulongne, Lina Lapeyre, Karine Bolloré, Edouard Tuaillon, Nejla Erkilic, Vasiliki Kalatzis, Sylvie Lecollinet, Cécile Beck, Nelly Pirot, Yaël Glasson, Fabien Gosselet, Maria Teresa Alvarez Martinez, Philippe Van de Perre, Sara Salinas, Yannick Simonin

PLOS Neglected Tropical Diseases: published April 23, 2020 | https://doi.org/10.1371/journal.pntd.0008223

Helicobacter pylori infection is associated with fecal biomarkers of environmental enteric dysfunction but not with the nutritional status of children living in Bangladesh

Shah Mohammad Fahim, Subhasish Das, Md. Amran Gazi, Md. Ashraful Alam, Md. Mehedi Hasan, Md. Shabab Hossain, Mustafa Mahfuz, M Masudur Rahman, Rashidul Haque, Shafiqul Alam Sarker, Ramendra Nath Mazumder, Tahmeed Ahmed

PLOS Neglected Tropical Diseases: published April 23, 2020 | https://doi.org/10.1371/journal.pntd.0008243

Urine-based antigen detection assay for diagnosis of visceral leishmaniasis using monoclonal antibodies specific for six protein biomarkers of Leishmania infantum / Leishmania donovani

Claudia Abeijon, Fabiana Alves, Séverine Monnerat, Jane Mbui, Agostinho G. Viana, Raquel M. Almeida, Lilian L. Bueno, Ricardo T. Fujiwara, Antonio Campos-Neto

PLOS Neglected Tropical Diseases: published April 23, 2020 | https://doi.org/10.1371/journal.pntd.0008246

Role of asymptomatic and symptomatic humans as reservoirs of visceral leishmaniasis in a Mediterranean context

Ricardo Molina, Maribel Jiménez, Jesús García-Martínez, Juan Víctor San Martín, Eugenia Carrillo, Carmen Sánchez, Javier Moreno, Fabiana Alves, Jorge Alvar

PLOS Neglected Tropical Diseases: published April 23, 2020 | https://doi.org/10.1371/journal.pntd.0008253

Seroprevalence of leptospiral antibodies in rodents from riverside communities of Santa Fe, Argentina

Tamara Ricardo, Paulina Jacob, Yosena Chiani, María Fernanda Schmeling, Paula Cornejo, Agustina Alejandra Ojeda, Pablo Vicente Teta, Norma Bibiana Vanasco, María Andrea Previtali

PLOS Neglected Tropical Diseases: published April 24, 2020 | https://doi.org/10.1371/journal.pntd.0008222

Clinicopathological aspects and proviral load of adulthood infective dermatitis associated with HTLV-1: Comparison between juvenile and adulthood forms

Lucca Santos Souza, Thadeu Santos Silva, Maria de Fátima Paim de Oliveira, Lourdes Farre, Achiléa Lisboa Bittencourt

PLOS Neglected Tropical Diseases: published April 24, 2020 | https://doi.org/10.1371/journal.pntd.0008241

Comparison of multi-parallel qPCR and double-slide Kato-Katz for detection of soil-transmitted helminth infection among children in rural Bangladesh

Jade Benjamin-Chung, Nils Pilotte, Ayse Ercumen, Jessica R. Grant, Jacqueline R. M. A. Maasch, Andrew M. Gonzalez, Ashanta C. Ester, Benjamin F. Arnold, Mahbubur Rahman, Rashidul Haque, Alan E. Hubbard, Stephen P. Luby, Steven A. Williams, John M. Colford Jr

PLOS Neglected Tropical Diseases: published April 24, 2020 | https://doi.org/10.1371/journal.pntd.0008087

Reservoirs and transmission routes of leprosy; A systematic review

Thomas Ploemacher, William R. Faber, Henk Menke, Victor Rutten, Toine Pieters

PLOS Neglected Tropical Diseases: published April 27, 2020 | https://doi.org/10.1371/journal.pntd.0008276

Assessing expanded community wide treatment for schistosomiasis: Baseline infection status and self-reported risk factors in three communities from the Greater Accra region, Ghana

Lucas J. Cunningham, Suzy J. Campbell, Samuel Armoo, Artemis Koukounari, Victoria Watson, Pamela Selormey, J. Russell Stothard, Bright Idun, Manfred Asiedu, Yvonne Ashong, Emily R. Adams, Mike Yaw Osei-Atweneboana

PLOS Neglected Tropical Diseases: published April 27, 2020 | https://doi.org/10.1371/journal.pntd.0007973

Guillain-Barré syndrome related to Zika virus infection: A systematic review and meta-analysis of the clinical and electrophysiological phenotype

Sonja E. Leonhard, Cristiane C. Bresani-Salvi, Joanna D. Lyra Batista, Sergio Cunha, Bart C. Jacobs, Maria Lucia Brito Ferreira, Maria de Fatima P. Militão de Albuquerque

PLOS Neglected Tropical Diseases: published April 27, 2020 | https://doi.org/10.1371/journal.pntd.0008264

Molecular characterization of a Trichinella spiralis aspartic protease and its facilitation role in larval invasion of host intestinal epithelial cells

Jia Xu, Ruo Dan Liu, Sheng Jie Bai, Hui Nan Hao, Wen Wen Yue, Yang Xiu Yue Xu, Shao Rong Long, Jing Cui, Zhong Quan Wang

PLOS Neglected Tropical Diseases: published April 27, 2020 | https://doi.org/10.1371/journal.pntd.0008269

Mycetoma in Uganda: A neglected tropical disease

Richard Kwizera, Felix Bongomin, David B. Meya, David W. Denning, Ahmed H. Fahal, Robert Lukande

PLOS Neglected Tropical Diseases: published April 29, 2020 | https://doi.org/10.1371/journal.pntd.0008240

New estimates of the Zika virus epidemic attack rate in Northeastern Brazil from 2015 to 2016: A modelling analysis based on Guillain-Barré Syndrome (GBS) surveillance data

Daihai He, Shi Zhao, Qianying Lin, Salihu S. Musa, Lewi Stone

PLOS Neglected Tropical Diseases: published April 29, 2020 | https://doi.org/10.1371/journal.pntd.0007502

Familial assimilation in transmission of raw-freshwater fish-eating practice leading to clonorchiasis

Men-Bao Qian, Zhi-Hua Jiang, Chang-Hai Zhou, Tao Ge, Xin Wang, Xiao-Nong Zhou

PLOS Neglected Tropical Diseases: published April 30, 2020 | https://doi.org/10.1371/journal.pntd.0008263

Investigating barriers and challenges to the integrated management of neglected tropical skin diseases in an endemic setting in Nigeria

Kingsley N. Ukwaja, Chukwuka Alphonsus, Chinwe C. Eze, Linda Lehman, Ngozi Ekeke, Charles C. Nwafor, Joy Ikebudu, Moses C. Anyim, Joseph N. Chukwu

PLOS Neglected Tropical Diseases: published April 30, 2020 | https://doi.org/10.1371/journal.pntd.0008248

A prospective study of bloodstream infections among febrile adolescents and adults attending Yangon General Hospital, Yangon, Myanmar

Tin Ohn Myat, Khine Mar Oo, Hla Kye Mone, Wah Win Htike, Ambarish Biswas, Rachel F. Hannaway, David R. Murdoch, James E. Ussher, John A. Crump

PLOS Neglected Tropical Diseases: published April 30, 2020 | https://doi.org/10.1371/journal.pntd.0008268

Amino acids serve as an important energy source for adult flukes of Clonorchis sinensis

Shan Li, Xueqing Chen, Juanjuan Zhou, Zhizhi Xie, Mei Shang, Lei He, Pei Liang, Tingjin Chen, Qiang Mao, Chi Liang, Xuerong Li, Yan Huang, Xinbing Yu

PLOS Neglected Tropical Diseases: published April 30, 2020 | https://doi.org/10.1371/journal.pntd.0008287