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Table of Contents

April 2018

Identifying the environmental sources of pathogenic Leptospira is key to design public health interventions aimed at reducing the burden of leptospirosis in vulnerable populations. Schneider et al., 2018

Image Credit: Andrew G. Schneider

Viewpoints

Could violent conflict derail the London Declaration on NTDs?

Rebecca Y. Du, Jeffrey D. Stanaway, Peter J. Hotez

Safeguarding against Ebola: Vaccines and therapeutics to be stockpiled for future outbreaks

Eric M. Espeland, Chia-Wei Tsai, Joseph Larsen, Gary L. Disbrow

Symposium

Haemophilus ducreyi cutaneous ulcer contracted at Seram Island, Indonesia, presented in the Netherlands

Jarne M. van Hattem, Tessa J. C. Langeveld, Sylvia M. Bruisten, Marion Kolader, Martin P. Grobusch, Henry J. C. de Vries, Godelieve J. de Bree

Reviews

Rodent-borne diseases and their public health importance in Iran

Mohammad Hasan Rabiee, Ahmad Mahmoudi, Roohollah Siahsarvie, Boris Kryštufek, Ehsan Mostafavi

Research Articles

Metabolite profiling for biomarkers in Schistosoma haematobium infection and associated bladder pathologies

Adewale S. Adebayo, Swapnil D. Mundhe, Henrietta O. Awobode, Olugbenga S. Onile, Atinuke M. Agunloye, Raphael D. Isokpehi, Yogesh S. Shouche, Bayatigeri Santhakumari, Chiaka I. Anumudu

Microdeletion on chromosome 8p23.1 in a familial form of severe Buruli ulcer

Quentin B. Vincent, Aziz Belkadi, Cindy Fayard, Estelle Marion, Ambroise Adeye, Marie-Françoise Ardant, Christian R. Johnson, Didier Agossadou, Lazaro Lorenzo, Julien Guergnon, Christine Bole-Feysot, Jeremy Manry, Patrick Nitschké, Ioannis Theodorou, Jean-Laurent Casanova, Laurent Marsollier, Annick Chauty, Laurent Abel, Alexandre Alcaïs, Franco-Beninese Buruli Research Group

Characterization of a novel organic solute transporter homologue from Clonorchis sinensis

Yanyan Lu, Won Gi Yoo, Fuhong Dai, Ji-Yun Lee, Jhang Ho Pak, Woon-Mok Sohn, Sung-Jong Hong

Efficacy and safety of co-administered ivermectin plus albendazole for treating soil-transmitted helminths: A systematic review, meta-analysis and individual patient data analysis

Marta S. Palmeirim, Eveline Hürlimann, Stefanie Knopp, Benjamin Speich, Vicente Belizario Jr., Serene A. Joseph, Michel Vaillant, Piero Olliaro, Jennifer Keiser

Impact of lower challenge doses of enterotoxigenic Escherichia coli on clinical outcome, intestinal colonization and immune responses in adult volunteers

Subhra Chakraborty, Clayton Harro, Barbara DeNearing, Jessica Brubaker, Sean Connor, Nicole Maier, Len Dally, Jorge Flores, A. Louis Bourgeois, Richard Walker, David A. Sack

Identification and characterization of the Fasciola hepatica sodium- and chloride-dependent taurine transporter

Bulut Hamali, Sandra Pichler, Elisabeth Wischnitzki, Klaus Schicker, Melanie Burger, Marion Holy, Kathrin Jaentsch, Martina Molin, Eva Maria Sehr, Oliver Kudlacek, Michael Freissmuth

Addressing the most neglected diseases through an open research model: The discovery of fenarimols as novel drug candidates for eumycetoma

Wilson Lim, Youri Melse, Mickey Konings, Hung Phat Duong, Kimberly Eadie, Benoît Laleu, Benjamin Perry, Matthew H. Todd, Jean-Robert Ioset, Wendy W. J. van de Sande

Hepatitis B and hepatitis D virus infections in the Central African Republic, twenty-five years after a fulminant hepatitis outbreak, indicate continuing spread in asymptomatic young adults

Narcisse Patrice Komas, Sumantra Ghosh, Mariama Abdou-Chekaraou, Pierre Pradat, Nasser Al Hawajri, Alexandre Manirakiza, Gina Laure Laghoe, Claudine Bekondi, Ségolène Brichler, Jean-Omer Ouavéné, Abdoulaye Sépou, Brice Martial Yambiyo, Jean Chrysostome Gody, Valentin Fikouma, Athénais Gerber, Natali Abeywickrama Samarakoon, Dulce Alfaiate, Caroline Scholtès, Nora Martel, Frédéric Le Gal, Hugo Lo Pinto, Ikram Amri, Olivier Hantz, David Durantel, Jean-Louis Lesbordes, Emmanuel Gordien, Philippe Merle, Tudor Drugan, Christian Trépo, Fabien Zoulim, Jean-Claude Cortay, Alan Campbell Kay, Paul Dény

Enhanced surveillance for Rift Valley Fever in livestock during El Niño rains and threat of RVF outbreak, Kenya, 2015-2016

Harry Oyas, Lindsey Holmstrom, Naomi P. Kemunto, Matthew Muturi, Athman Mwatondo, Eric Osoro, Austine Bitek, Bernard Bett, Jane W. Githinji, Samuel M. Thumbi, Marc-Alain Widdowson, Peninah M. Munyua, M. Kariuki Njenga

Aminopeptidase secreted by Chromobacterium sp. Panama inhibits dengue virus infection by degrading the E protein

Raúl G. Saraiva, Jingru Fang, Seokyoung Kang, Yesseinia I. Angleró-Rodríguez, Yuemei Dong, George Dimopoulos

Data quality and timeliness of outbreak reporting system among countries in Greater Mekong subregion: Challenges for international data sharing

Saranath Lawpoolsri, Jaranit Kaewkungwal, Amnat Khamsiriwatchara, Ly Sovann, Bun Sreng, Bounlay Phommasack, Viengsavanh Kitthiphong, Soe Lwin Nyein, Nyan Win Myint, Nguyen Dang Vung, Pham Hung, Mark S. Smolinski, Adam W. Crawley, Moe Ko Oo

Zika virus infection and microcephaly: Evidence regarding geospatial associations

João Ricardo Nickenig Vissoci, Thiago Augusto Hernandes Rocha, Núbia Cristina da Silva, Rejane Christine de Sousa Queiroz, Erika Bárbara Abreu Fonseca Thomaz, Pedro Vasconcelos Maia Amaral, Adriana Lein, Maria dos Remédios Freitas Carvalho Branco, José Aquino Junior, Zulimar Márita Ribeiro Rodrigues, Antônio Augusto Moura da Silva, Catherine Staton

Impact of confinement housing on study end-points in the calf model of cryptosporidiosis

Geneva Graef, Natalie J. Hurst, Lance Kidder, Tracy L. Sy, Laura B. Goodman, Whitney D. Preston, Samuel L. M. Arnold, Jennifer A. Zambriski

Cryosurgery for the treatment of cutaneous sporotrichosis in four pregnant women

Vivian Fichman, Antonio Carlos Francesconi do Valle, Priscila Marques de Macedo, Dayvison Francis Saraiva Freitas, Manoel Marques Evangelista de Oliveira, Rodrigo Almeida-Paes, Maria Clara Gutierrez-Galhardo

Entomopathogenic fungal infection leads to temporospatial modulation of the mosquito immune system

José L. Ramirez, Christopher A. Dunlap, Ephantus J. Muturi, Ana B. F. Barletta, Alejandro P. Rooney

Behavioral responses of Rhodnius prolixus to volatile organic compounds released in vitro by bacteria isolated from human facial skin

Marcela Tabares, Mario Ortiz, Mabel Gonzalez, Chiara Carazzone, Martha J. Vives Florez, Jorge Molina

Laboratory and molecular surveillance of paediatric typhoidal Salmonella in Nepal: Antimicrobial resistance and implications for vaccine policy

Carl D. Britto, Zoe A. Dyson, Sebastian Duchene, Michael J. Carter, Meeru Gurung, Dominic F. Kelly, David R. Murdoch, Imran Ansari, Stephen Thorson, Shrijana Shrestha, Neelam Adhikari, Gordon Dougan, Kathryn E. Holt, Andrew J. Pollard

Plasma and memory B cell responses targeting O-specific polysaccharide (OSP) are associated with protection against Vibrio cholerae O1 infection among household contacts of cholera patients in Bangladesh

Amena Aktar, M. Arifur Rahman, Sadia Afrin, Aklima Akter, Taher Uddin, Tahirah Yasmin, Md. Israk Nur Sami, Pinki Dash, Sultana Rownok Jahan, Fahima Chowdhury, Ashraful I. Khan, Regina C. LaRocque, Richelle C. Charles, Taufiqur Rahman Bhuiyan, Anjali Mandlik, Meagan Kelly, Pavol Kováč, Peng Xu, Stephen B. Calderwood, Jason B. Harris, Firdausi Qadri, Edward T. Ryan

Open label comparative trial of mono versus dual antibiotic therapy for Typhoid Fever in adults

Niv Zmora, Sudeep Shrestha, Ami Neuberger, Yael Paran, Rajendra Tamrakar, Ashish Shrestha, Surendra K. Madhup, T. R. S. Bedi, Rajendra Koju, Eli Schwartz

First cases of European bat lyssavirus type 1 in Iberian serotine bats: Implications for the molecular epidemiology of bat rabies in Europe

Patricia Mingo-Casas, Virginia Sandonís, Elena Obón, José M. Berciano, Sonia Vázquez-Morón, Javier Juste, Juan E. Echevarría

SmSP2: A serine protease secreted by the blood fluke pathogen Schistosoma mansoni with anti-hemostatic properties

Adrian Leontovyč, Lenka Ulrychová, Anthony J. O’Donoghue, Jiří Vondrášek, Lucie Marešová, Martin Hubálek, Pavla Fajtová, Marta Chanová, Zhenze Jiang, Charles S. Craik, Conor R. Caffrey, Michael Mareš, Jan Dvořák, Martin Horn

Morphophysiological changes in the splenic extracellular matrix of Leishmania infantum-naturally infected dogs is associated with alterations in lymphoid niches and the CD4+ T cell frequency in spleens

Aurea Virginia Andrade da Silva, Fabiano Borges Figueiredo, Rodrigo Caldas Menezes, Arthur Augusto Mendes-Junior, Luisa Helena Monteiro de Miranda, Elisa Cupolillo, Renato Porrozzi, Fernanda Nazaré Morgado

Implications of current therapeutic restrictions for primaquine and tafenoquine in the radical cure of vivax malaria

James Watson, Walter R. J. Taylor, Germana Bancone, Cindy S. Chu, Podjanee Jittamala, Nicholas J. White

Progress in the pharmacological treatment of human cystic and alveolar echinococcosis: Compounds and therapeutic targets

Mar Siles-Lucas, Adriano Casulli, Roberto Cirilli, David Carmena

A 2015 outbreak of flea-borne rickettsiosis in San Gabriel Valley, Los Angeles County, California

Kimberly Nelson, Alice N. Maina, Angela Brisco, Chelsea Foo, Curtis Croker, Van Ngo, Rachel Civen, Allen L. Richards, Kenn Fujioka, J. Wakoli Wekesa

Vector competence of Italian Aedes albopictus populations for the chikungunya virus (E1-226V)

Francesco Severini, Daniela Boccolini, Claudia Fortuna, Marco Di Luca, Luciano Toma, Antonello Amendola, Eleonora Benedetti, Giada Minelli, Roberto Romi, Giulietta Venturi, Giovanni Rezza, Maria Elena Remoli

Nucleobases and corresponding nucleosides display potent antiviral activities against dengue virus possibly through viral lethal mutagenesis

Li Qiu, Steven E. Patterson, Laurent F. Bonnac, Robert J. Geraghty

Point-of-care tests for syphilis and yaws in a low-income setting – A qualitative study of healthcare worker and patient experiences

Michael Marks, Tommy Esau, Rowena Asugeni, Relmah Harrington, Jason Diau, Hilary Toloka, James Asugeni, Eimhin Ansbro, Anthony W. Solomon, David Maclaren, Michelle Redman-Maclaren, David C. W. Mabey

Activation of host transient receptor potential (TRP) channels by praziquantel stereoisomers

Gihan S. Gunaratne, Nawal A. Yahya, Peter I. Dosa, Jonathan S. Marchant

Establishment of a mouse model for the complete mosquito-mediated transmission cycle of Zika virus

Yi-Ping Kuo, Kuen-Nan Tsai, Yin-Chiu Luo, Pei-Jung Chung, Yu-Wen Su, Yu Teng, Ming-Sian Wu, Yu-Feng Lin, Chao-Yang Lai, Tsung-Hsien Chuang, Shih-Syong Dai, Fan-Chen Tseng, Cheng-Han Hsieh, De-Jiun Tsai, Wan-Ting Tsai, Chun-Hong Chen, Guann-Yi Yu

Similarities and differences between helminth parasites and cancer cell lines in shaping human monocytes: Insights into parallel mechanisms of immune evasion

Prakash Babu Narasimhan, Leor Akabas, Sameha Tariq, Naureen Huda, Sasisekhar Bennuru, Helen Sabzevari, Robert Hofmeister, Thomas B. Nutman, Roshanak Tolouei Semnani

Genetic profiling of Mycobacterium bovis strains from slaughtered cattle in Eritrea

Michael Kahsay Ghebremariam, Tiny Hlokwe, Victor P. M. G. Rutten, Alberto Allepuz, Simeon Cadmus, Adrian Muwonge, Suelee Robbe-Austerman, Anita L. Michel

Body lice of homeless people reveal the presence of several emerging bacterial pathogens in northern Algeria

Meriem Louni, Nassima Mana, Idir Bitam, Mustapha Dahmani, Philippe Parola, Florence Fenollar, Didier Raoult, Oleg Mediannikov

Profiling extracellular vesicle release by the filarial nematode Brugia malayi reveals sex-specific differences in cargo and a sensitivity to ivermectin

Hiruni Harischandra, Wang Yuan, Hannah J. Loghry, Mostafa Zamanian, Michael J. Kimber

In vitro assessment of cytotoxic activities of Lachesis muta muta snake venom

Stephanie Stransky, Fernanda Costal-Oliveira, Letícia Lopes-de-Souza, Clara Guerra-Duarte, Carlos Chávez-Olórtegui, Vania Maria Martin Braga

The impact of school water, sanitation, and hygiene improvements on infectious disease using serum antibody detection

Anna N. Chard, Victoria Trinies, Delynn M. Moss, Howard H. Chang, Seydou Doumbia, Patrick J. Lammie, Matthew C. Freeman

Replication-incompetent rabies virus vector harboring glycoprotein gene of lymphocytic choriomeningitis virus (LCMV) protects mice from LCMV challenge

Mutsuyo Takayama-Ito, Chang-Kweng Lim, Yukie Yamaguchi, Guillermo Posadas-Herrera, Hirofumi Kato, Itoe Iizuka, Md. Taimur Islam, Kinjiro Morimoto, Masayuki Saijo

The non-linear and lagged short-term relationship between rainfall and leptospirosis and the intermediate role of floods in the Philippines

Naohiko Matsushita, Chris Fook Sheng Ng, Yoonhee Kim, Motoi Suzuki, Nobuo Saito, Koya Ariyoshi, Eumelia P. Salva, Efren M. Dimaano, Jose B. Villarama, Winston S. Go, Masahiro Hashizume

Sialome diversity of ticks revealed by RNAseq of single tick salivary glands

Jan Perner, Sára Kropáčková, Petr Kopáček, José M. C. Ribeiro

Insulin receptor knockdown blocks filarial parasite development and alters egg production in the southern house mosquito, Culex quinquefasciatus

Andrew Bradley Nuss, Mark R. Brown, Upadhyayula Suryanarayana Murty, Monika Gulia-Nuss

Serosurveillance of Coxiellosis (Q-fever) and Brucellosis in goats in selected provinces of Lao People’s Democratic Republic

Rebekah J. L. Burns, Bounlom Douangngeun, Watthana Theppangna, Syseng Khounsy, Mavuto Mukaka, Paul W. Selleck, Eric Hansson, Matthew D. Wegner, Peter A. Windsor, Stuart D. Blacksell

Gene target selection for loop-mediated isothermal amplification for rapid discrimination of Treponema pallidum subspecies

Sascha Knauf, Simone Lüert, David Šmajs, Michal Strouhal, Idrissa S. Chuma, Sieghard Frischmann, Mohammed Bakheit

Bacterial and protozoal pathogens found in ticks collected from humans in Corum province of Turkey

Djursun Karasartova, Ayse Semra Gureser, Tuncay Gokce, Bekir Celebi, Derya Yapar, Adem Keskin, Selim Celik, Yasemin Ece, Ali Kemal Erenler, Selma Usluca, Kosta Y. Mumcuoglu, Aysegul Taylan-Ozkan

Development of the multi-epitope chimeric antigen rqTSA-25 from Taenia saginata for serological diagnosis of bovine cysticercosis

Rafaella P. M. Guimarães-Peixoto, Paulo S. A. Pinto, Marcus R. Santos, Tiago J. Zilch, Paula F. Apolinário, Abelardo Silva-Júnior

Decision support for evidence-based integration of disease control: A proof of concept for malaria and schistosomiasis

Claire J. Standley, Ellie Graeden, Justin Kerr, Erin M. Sorrell, Rebecca Katz

Suppression of the pelo protein by Wolbachia and its effect on dengue virus in Aedes aegypti

Sultan Asad, Mazhar Hussain, Leon Hugo, Solomon Osei-Amo, Guangmei Zhang, Daniel Watterson, Sassan Asgari

Development of an autodissemination strategy for the deployment of novel control agents targeting the common malaria mosquito, Anopheles quadrimaculatus say (Diptera: Culicidae)

Daniel R. Swale, Zhilin Li, Jake Z. Kraft, Kristen Healy, Mei Liu, Connie M. David, Zhijun Liu, Lane D. Foil

High susceptibility of magpie (Pica pica) to experimental infection with lineage 1 and 2 West Nile virus

Nereida Jiménez de Oya, María-Cruz Camacho, Ana-Belén Blázquez, José-Francisco Lima-Barbero, Juan-Carlos Saiz, Ursula Höfle, Estela Escribano-Romero

Community knowledge, attitudes and practices on Yellow fever in South Omo area, Southern Ethiopia

Mengistu Legesse, Adugna Endale, Woldearegay Erku, Getachew Tilahun, Girmay Medhin

Dynamics of cholera epidemics from Benin to Mauritania

Sandra Moore, Anthony Zunuo Dongdem, David Opare, Paul Cottavoz, Maria Fookes, Adodo Yao Sadji, Emmanuel Dzotsi, Michael Dogbe, Fakhri Jeddi, Bawimodom Bidjada, Martine Piarroux, Ouyi Tante Valentin, Clément Kakaï Glèlè, Stanislas Rebaudet, Amy Gassama Sow, Guillaume Constantin de Magny, Lamine Koivogui, Jessica Dunoyer, Francois Bellet, Eric Garnotel, Nicholas Thomson, Renaud Piarroux

Unintended consequences and the paradox of control: Management of emerging pathogens with age-specific virulence

Spencer Carran, Matthew Ferrari, Timothy Reluga

Geospatial-temporal distribution of Tegumentary Leishmaniasis in Colombia (2007–2016)

Giovanny Herrera, Aníbal Teherán, Iván Pradilla, Mauricio Vera, Juan David Ramírez

Quantification of pathogenic Leptospira in the soils of a Brazilian urban slum

Andrew G. Schneider, Arnau Casanovas-Massana, Kathryn P. Hacker, Elsio A. Wunder Jr., Mike Begon, Mitermayer G. Reis, James E. Childs, Federico Costa, Janet C. Lindow, Albert I. Ko

Social determinants, their relationship with leprosy risk and temporal trends in a tri-border region in Latin America

Ivaneliza Simionato de Assis, Marcos Augusto Moraes Arcoverde, Antônio Carlos Viera Ramos, Luana Seles Alves, Thais Zamboni Berra, Luiz Henrique Arroyo, Ana Angélica Rêgo de Queiroz, Danielle Talita dos Santos, Aylana de Souza Belchior, Josilene Dália Alves, Flávia Meneguetti Pieri, Reinaldo Antônio Silva-Sobrinho, Ione Carvalho Pinto, Clodis Maria Tavares, Mellina Yamamura, Marco Andrey Cipriani Frade, Pedro Fredemir Palha, Francisco Chiaravalloti-Neto, Ricardo Alexandre Arcêncio

Efficacy of Aedes aegypti control by indoor Ultra Low Volume (ULV) insecticide spraying in Iquitos, Peru

Christian E. Gunning, Kenichi W. Okamoto, Helvio Astete, Gissella M. Vasquez, Erik Erhardt, Clara Del Aguila, Raul Pinedo, Roldan Cardenas, Carlos Pacheco, Enrique Chalco, Hugo Rodriguez-Ferruci, Thomas W. Scott, Alun L. Lloyd, Fred Gould, Amy C. Morrison

Anti-O-specific polysaccharide (OSP) immune responses following vaccination with oral cholera vaccine CVD 103-HgR correlate with protection against cholera after infection with wild-type Vibrio cholerae O1 El Tor Inaba in North American volunteers

Kamrul Islam, Motaher Hossain, Meagan Kelly, Leslie M. Mayo Smith, Richelle C. Charles, Taufiqur Rahman Bhuiyan, Pavol Kováč, Peng Xu, Regina C. LaRocque, Stephen B. Calderwood, Jakub K. Simon, Wilbur H. Chen, Douglas Haney, Michael Lock, Caroline E. Lyon, Beth D. Kirkpatrick, Mitchell Cohen, Myron M. Levine, Marc Gurwith, Jason B. Harris, Firdausi Qadri, Edward T. Ryan

Hidden danger: Unexpected scenario in the vector-parasite dynamics of leishmaniases in the Brazil side of triple border (Argentina, Brazil and Paraguay)

Vanete Thomaz-Soccol, André Luiz Gonçalves, Claudio Adriano Piechnik, Rafael Antunes Baggio, Walter Antônio Boeger, Themis Leão Buchman, Mario Sergio Michaliszyn, Demilson Rodrigues dos Santos, Adão Celestino, José Aquino Jr, André de Souza Leandro, Otacílio Lopes de Souza da Paz, Marcelo Limont, Alceu Bisetto Jr, Jeffrey Jon Shaw, Zaida Estela Yadon, Oscar Daniel Salomon

The impact of passive case detection on the transmission dynamics of gambiense Human African Trypanosomiasis

Francesco Checchi, Sebastian Funk, Daniel Chandramohan, François Chappuis, Daniel T. Haydon

Clinical Cysticercosis epidemiology in Spain based on the hospital discharge database: What's new?

Zaida Herrador, Amalia Fernandez-Martinez, Agustín Benito, Rogelio Lopez-Velez

A real-time PCR tool for the surveillance of zoonotic Onchocerca lupi in dogs, cats and potential vectors

Maria Stefania Latrofa, Giada Annoscia, Vito Colella, Maria Alfonsa Cavalera, Carla Maia, Coralie Martin, Jan Šlapeta, Domenico Otranto

Refractoriness of Sergentomyia schwetzi to Leishmania spp. is mediated by the peritrophic matrix

Jovana Sadlova, Miroslav Homola, Jitka Myskova, Magdalena Jancarova, Petr Volf

Expanding the toolbox for Trypanosoma cruzi: A parasite line incorporating a bioluminescence-fluorescence dual reporter and streamlined CRISPR/Cas9 functionality for rapid in vivo localisation and phenotyping

Fernanda Cristina Costa, Amanda Fortes Francisco, Shiromani Jayawardhana, Simone Guedes Calderano, Michael D. Lewis, Francisco Olmo, Tom Beneke, Eva Gluenz, Jack Sunter, Samuel Dean, John Morrison Kelly, Martin Craig Taylor

The effectiveness of water treatment processes against schistosome cercariae: A systematic review

Laura Braun, Jack E. T. Grimes, Michael R. Templeton

Development of a Trypanosoma cruzi strain typing assay using MS2 peptide spectral libraries (Tc-STAMS2)

Gilberto Santos de Oliveira, Rebeca Kawahara, Livia Rosa-Fernandes, Simon Ngao Mule, Carla Cristi Avila, Marta M. G. Teixeira, Martin R. Larsen, Giuseppe Palmisano

A field study of the survival and dispersal pattern of Lutzomyia longipalpis in an endemic area of visceral leishmaniasis in Brazil

Fredy Galvis-Ovallos, Claudio Casanova, Denise Pimentel Bergamaschi, Eunice Aparecida Bianchi Galati