August 2015

The ears of the hippo are only an indication of its presence, not its size. Wamala et al.

Image Credit: Kiara Cannon

Editorial

Building Research and Development Capacity for Neglected Tropical Diseases Impacting Leishmaniasis in the Middle East and North Africa: A Case Study

Sima Rafati, Shaden Kamhawi, Jesus G. Valenzuela, Mostafa Ghanei

PLOS Neglected Tropical Diseases: published August 27, 2015 | https://doi.org/10.1371/journal.pntd.0003695

Viewpoints

Should the Goal for the Treatment of Soil Transmitted Helminth (STH) Infections Be Changed from Morbidity Control in Children to Community-Wide Transmission Elimination?

Roy M. Anderson, Hugo C. Turner, James E. Truscott, T. Déirdre Hollingsworth, Simon J. Brooker

PLOS Neglected Tropical Diseases: published August 20, 2015 | https://doi.org/10.1371/journal.pntd.0003897

Nodding Syndrome May Be Only the Ears of the Hippo

Joseph Francis Wamala, Mugagga Malimbo, Floribert Tepage, Luswa Lukwago, Charles Lukoya Okot, Robert O. Cannon, Anne Laudisoit, Robert Colebunders

PLOS Neglected Tropical Diseases: published August 13, 2015 | https://doi.org/10.1371/journal.pntd.0003880

Is a Cholera Outbreak Preventable in Post-earthquake Nepal?

Eric J. Nelson, Jason R. Andrews, Stacey Maples, Michele Barry, John D. Clemens

PLOS Neglected Tropical Diseases: published August 13, 2015 | https://doi.org/10.1371/journal.pntd.0003961

Responsible Use of Pop Culture and Communication in the Face of Ebola Virus

Brandon Brown, Melissa Nasiruddin, Alexander Dao, Monique Halabi

PLOS Neglected Tropical Diseases: published August 6, 2015 | https://doi.org/10.1371/journal.pntd.0003890

Research Articles

Increased Nucleosomes and Neutrophil Activation Link to Disease Progression in Patients with Scrub Typhus but Not Murine Typhus in Laos

Daniel H. Paris, Femke Stephan, Ingrid Bulder, Diana Wouters, Tom van der Poll, Paul N. Newton, Nicholas P. J. Day, Sacha Zeerleder

PLOS Neglected Tropical Diseases: published August 28, 2015 | https://doi.org/10.1371/journal.pntd.0003990

Improved Quantification, Propagation, Purification and Storage of the Obligate Intracellular Human Pathogen Orientia tsutsugamushi

Suparat Giengkam, Alex Blakes, Peemdej Utsahajit, Suwittra Chaemchuen, Sharanjeet Atwal, Stuart D. Blacksell, Daniel H. Paris, Nicholas P. J. Day, Jeanne Salje

PLOS Neglected Tropical Diseases: published August 28, 2015 | https://doi.org/10.1371/journal.pntd.0004009

The Diversity and Geographical Structure of Orientia tsutsugamushi Strains from Scrub Typhus Patients in Laos

Rattanaphone Phetsouvanh, Piengchan Sonthayanon, Sasithon Pukrittayakamee, Daniel H. Paris, Paul N. Newton, Edward J. Feil, Nicholas P. J. Day

PLOS Neglected Tropical Diseases: published August 28, 2015 | https://doi.org/10.1371/journal.pntd.0004024

Bile Salts Modulate the Mucin-Activated Type VI Secretion System of Pandemic Vibrio cholerae

Verena Bachmann, Benjamin Kostiuk, Daniel Unterweger, Laura Diaz-Satizabal, Stephen Ogg, Stefan Pukatzki

PLOS Neglected Tropical Diseases: published August 28, 2015 | https://doi.org/10.1371/journal.pntd.0004031

rPbPga1 from Paracoccidioides brasiliensis Activates Mast Cells and Macrophages via NFkB

Clarissa Xavier Resende Valim, Elaine Zayas Marcelino da Silva, Mariana Aprigio Assis, Fabricio Freitas Fernandes, Paulo Sergio Rodrigues Coelho, Constance Oliver, Maria Célia Jamur

PLOS Neglected Tropical Diseases: published August 28, 2015 | https://doi.org/10.1371/journal.pntd.0004032

Involvement of PSMD10, CDK4, and Tumor Suppressors in Development of Intrahepatic Cholangiocarcinoma of Syrian Golden Hamsters Induced by Clonorchis sinensis and N-Nitrosodimethylamine

Md. Hafiz Uddin, Min-Ho Choi, Woo Ho Kim, Ja-June Jang, Sung-Tae Hong

PLOS Neglected Tropical Diseases: published August 27, 2015 | https://doi.org/10.1371/journal.pntd.0004008

Immunogenicity and Serological Cross-Reactivity of Saliva Proteins among Different Tsetse Species

Xin Zhao, Thiago Luiz Alves e Silva, Laura Cronin, Amy F. Savage, Michelle O’Neill, Barbara Nerima, Loyce M. Okedi, Serap Aksoy

PLOS Neglected Tropical Diseases: published August 27, 2015 | https://doi.org/10.1371/journal.pntd.0004038

The Epigenome of Schistosoma mansoni Provides Insight about How Cercariae Poise Transcription until Infection

David Roquis, Julie M. J. Lepesant, Marion A. L. Picard, Michael Freitag, Hugues Parrinello, Marco Groth, Rémi Emans, Céline Cosseau, Christoph Grunau

PLOS Neglected Tropical Diseases: published August 25, 2015 | https://doi.org/10.1371/journal.pntd.0003853

Case Report: No Response to Liposomal Daunorubicin in a Patient with Drug-Resistant HIV-Associated Visceral Leishmaniasis

Nicholas J. Gow, Robert N. Davidson, Rob Ticehurst, Andrew Burns, Mark G. Thomas

PLOS Neglected Tropical Diseases: published August 25, 2015 | https://doi.org/10.1371/journal.pntd.0003983

Proteomics-Based Characterization of the Humoral Immune Response in Sporotrichosis: Toward Discovery of Potential Diagnostic and Vaccine Antigens

Anderson Messias Rodrigues, Geisa Ferreira Fernandes, Leticia Mendes Araujo, Paula Portella Della Terra, Priscila Oliveira dos Santos, Sandro Antonio Pereira, Tânia Maria Pacheco Schubach, Eva Burger, Leila Maria Lopes-Bezerra, Zoilo Pires de Camargo

PLOS Neglected Tropical Diseases: published August 25, 2015 | https://doi.org/10.1371/journal.pntd.0004016

Cyclooxygenase-2 and Prostaglandin E₂ Signaling through Prostaglandin Receptor EP-2 Favor the Development of Myocarditis during Acute Trypanosoma cruzi Infection

Néstor A. Guerrero, Mercedes Camacho, Luis Vila, Miguel A. Íñiguez, Carlos Chillón-Marinas, Henar Cuervo, Cristina Poveda, Manuel Fresno, Núria Gironès

PLOS Neglected Tropical Diseases: published August 25, 2015 | https://doi.org/10.1371/journal.pntd.0004025

Ecological Model to Predict Potential Habitats of Oncomelania hupensis, the Intermediate Host of Schistosoma japonicum in the Mountainous Regions, China

Hong-Ru Zhu, Lu Liu, Xiao-Nong Zhou, Guo-Jing Yang

PLOS Neglected Tropical Diseases: published August 25, 2015 | https://doi.org/10.1371/journal.pntd.0004028

Short-term Forecasting of the Prevalence of Trachoma: Expert Opinion, Statistical Regression, versus Transmission Models

Fengchen Liu, Travis C. Porco, Abdou Amza, Boubacar Kadri, Baido Nassirou, Sheila K. West, Robin L. Bailey, Jeremy D. Keenan, Anthony W. Solomon, Paul M. Emerson, Manoj Gambhir, Thomas M. Lietman

PLOS Neglected Tropical Diseases: published August 24, 2015 | https://doi.org/10.1371/journal.pntd.0004000

Spatio-temporal Genetic Structuring of Leishmania major in Tunisia by Microsatellite Analysis

Myriam Harrabi, Jihène Bettaieb, Wissem Ghawar, Amine Toumi, Amor Zaâtour, Rihab Yazidi, Sana Chaâbane, Bilel Chalghaf, Mallorie Hide, Anne-Laure Bañuls, Afif Ben Salah

PLOS Neglected Tropical Diseases: published August 24, 2015 | https://doi.org/10.1371/journal.pntd.0004017

Venom Concentrations and Clotting Factor Levels in a Prospective Cohort of Russell’s Viper Bites with Coagulopathy

Geoffrey K. Isbister, Kalana Maduwage, Fiona E. Scorgie, Seyed Shahmy, Fahim Mohamed, Chandana Abeysinghe, Harendra Karunathilake, Margaret A. O’Leary, Christeine A. Gnanathasan, Lisa F. Lincz

PLOS Neglected Tropical Diseases: published August 21, 2015 | https://doi.org/10.1371/journal.pntd.0003968

Type 2 Diabetes Mellitus Is Associated with Strongyloides stercoralis Treatment Failure in Australian Aboriginals

Russell Hays, Adrian Esterman, Robyn McDermott

PLOS Neglected Tropical Diseases: published August 21, 2015 | https://doi.org/10.1371/journal.pntd.0003976

Over-Expression of Cysteine Leucine Rich Protein Is Related to SAG Resistance in Clinical Isolates of Leishmania donovani

Sanchita Das, Priyanka Shah, Rati Tandon, Narendra Kumar Yadav, Amogh A. Sahasrabuddhe, Shyam Sundar, Mohammad Imran Siddiqi, Anuradha Dube

PLOS Neglected Tropical Diseases: published August 21, 2015 | https://doi.org/10.1371/journal.pntd.0003992

Epidemiological and Molecular Characterization of Dengue Virus Circulating in Bhutan, 2013-2014

Sangay Zangmo, Chonticha Klungthong, Piyawan Chinnawirotpisan, Srisurang Tantimavanich, Nathamon Kosoltanapiwat, Butsaya Thaisomboonsuk, Kelzang Phuntsho, Sonam Wangchuk, In-Kyu Yoon, Stefan Fernandez

PLOS Neglected Tropical Diseases: published August 21, 2015 | https://doi.org/10.1371/journal.pntd.0004010

Bacillus anthracis Diversity and Geographic Potential across Nigeria, Cameroon and Chad: Further Support of a Novel West African Lineage

Jason K. Blackburn, Moses Ode Odugbo, Matthew Van Ert, Bob O’Shea, Jocelyn Mullins, Vincent Perrenten, Angaya Maho, Martin Hugh-Jones, Ted Hadfield

PLOS Neglected Tropical Diseases: published August 20, 2015 | https://doi.org/10.1371/journal.pntd.0003931

Trypanosomes Modify the Behavior of Their Insect Hosts: Effects on Locomotion and on the Expression of a Related Gene

Newmar Pinto Marliére, José Manuel Latorre-Estivalis, Marcelo Gustavo Lorenzo, David Carrasco, Juliana Alves-Silva, Juliana de Oliveira Rodrigues, Luciana de Lima Ferreira, Luisa de Melo Lara, Carl Lowenberger, Alessandra Aparecida Guarneri

PLOS Neglected Tropical Diseases: published August 20, 2015 | https://doi.org/10.1371/journal.pntd.0003973

CD4⁺CD25^hiFOXP3⁺ Regulatory T Cells and Cytokine Responses in Human Schistosomiasis before and after Treatment with Praziquantel

Yvonne Schmiedel, Ghyslain Mombo-Ngoma, Lucja A. Labuda, Jacqueline J. Janse, Brechje de Gier, Ayôla A. Adegnika, Saadou Issifou, Peter G. Kremsner, Hermelijn H. Smits, Maria Yazdanbakhsh

PLOS Neglected Tropical Diseases: published August 20, 2015 | https://doi.org/10.1371/journal.pntd.0003995

Species-Specific Serological Detection for Schistosomiasis by Serine Protease Inhibitor (SERPIN) in Multiplex Assay

Chihiro Tanigawa, Yoshito Fujii, Masashi Miura, Samson Muuo Nzou, Anne Wanjiru Mwangi, Sachiyo Nagi, Shinjiro Hamano, Sammy M. Njenga, Evaristus Chibunna Mbanefo, Kenji Hirayama, Matilu Mwau, Satoshi Kaneko

PLOS Neglected Tropical Diseases: published August 20, 2015 | https://doi.org/10.1371/journal.pntd.0004021

Differential Host Immune Responses after Infection with Wild-Type or Lab-Attenuated Rabies Viruses in Dogs

Clement W. Gnanadurai, Yang Yang, Ying Huang, Zhenguang Li, Christina M. Leyson, Tanya L. Cooper, Simon R. Platt, Stephen B. Harvey, Douglas C. Hooper, Milosz Faber, Zhen F. Fu

PLOS Neglected Tropical Diseases: published August 20, 2015 | https://doi.org/10.1371/journal.pntd.0004023

A Comparison between Transcriptome Sequencing and 16S Metagenomics for Detection of Bacterial Pathogens in Wildlife

Maria Razzauti, Maxime Galan, Maria Bernard, Sarah Maman, Christophe Klopp, Nathalie Charbonnel, Muriel Vayssier-Taussat, Marc Eloit, Jean-François Cosson

PLOS Neglected Tropical Diseases: published August 18, 2015 | https://doi.org/10.1371/journal.pntd.0003929

Prevalence of Neurocysticercosis in People with Epilepsy in the Eastern Province of Zambia

Kabemba E. Mwape, Joachim Blocher, Jasmin Wiefek, Kathie Schmidt, Pierre Dorny, Nicolas Praet, Clarance Chiluba, Holger Schmidt, Isaac K. Phiri, Andrea S. Winkler, Sarah Gabriël

PLOS Neglected Tropical Diseases: published August 18, 2015 | https://doi.org/10.1371/journal.pntd.0003972

Comparative Analysis of Transcriptional Profiles of Adult Schistosoma japonicum from Different Laboratory Animals and the Natural Host, Water Buffalo

Shuai Liu, Xiaosu Zhou, Xianyu Piao, Chuang Wu, Nan Hou, Qijun Chen

PLOS Neglected Tropical Diseases: published August 18, 2015 | https://doi.org/10.1371/journal.pntd.0003993

Experimental Transmission of Karshi (Mammalian Tick-Borne Flavivirus Group) Virus by Ornithodoros Ticks >2,900 Days after Initial Virus Exposure Supports the Role of Soft Ticks as a Long-Term Maintenance Mechanism for Certain Flaviviruses

Michael J. Turell

PLOS Neglected Tropical Diseases: published August 18, 2015 | https://doi.org/10.1371/journal.pntd.0004012

Distribution of Peripheral Memory T Follicular Helper Cells in Patients with Schistosomiasis Japonica

Xiaojun Chen, Wei Li, Yang Zhang, Xian Song, Lei Xu, Zhipeng Xu, Sha Zhou, Jifeng Zhu, Xin Jin, Feng Liu, Gengxin Chen, Chuan Su

PLOS Neglected Tropical Diseases: published August 18, 2015 | https://doi.org/10.1371/journal.pntd.0004015

Spatio-temporal Use of Oral Rabies Vaccines in Fox Rabies Elimination Programmes in Europe

Thomas F. Müller, Ronald Schröder, Patrick Wysocki, Thomas C. Mettenleiter, Conrad M. Freuling

PLOS Neglected Tropical Diseases: published August 17, 2015 | https://doi.org/10.1371/journal.pntd.0003953

Development of Resistance to Pyrethroid in Culex pipiens pallens Population under Different Insecticide Selection Pressures

Linna Shi, Hongxia Hu, Kai Ma, Dan Zhou, Jing Yu, Daibin Zhong, Fujin Fang, Xuelian Chang, Shengli Hu, Feifei Zou, Weijie Wang, Yan Sun, Bo Shen, Donghui Zhang, Lei Ma, Guofa Zhou, Guiyun Yan, Changliang Zhu

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003928

ApiAP2 Factors as Candidate Regulators of Stochastic Commitment to Merozoite Production in Theileria annulata

Marta Pieszko, William Weir, Ian Goodhead, Jane Kinnaird, Brian Shiels

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003933

Lutzomyia longipalpis Presence and Abundance Distribution at Different Micro-spatial Scales in an Urban Scenario

María Soledad Santini, María Eugenia Utgés, Pablo Berrozpe, Mariana Manteca Acosta, Natalia Casas, Paola Heuer, O. Daniel Salomón

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003951

Role of sph2 Gene Regulation in Hemolytic and Sphingomyelinase Activities Produced by Leptospira interrogans

Suneel A. Narayanavari, Kristel Lourdault, Manjula Sritharan, David A. Haake, James Matsunaga

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003952

A Systematic Review of Mortality from Untreated Scrub Typhus (Orientia tsutsugamushi)

Andrew J. Taylor, Daniel H. Paris, Paul N. Newton

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003971

Spatial and Temporal Clustering of Chikungunya Virus Transmission in Dominica

Elaine O. Nsoesie, R. Paul Ricketts, Heidi E. Brown, Durland Fish, David P. Durham, Martial L. Ndeffo Mbah, Trudy Christian, Shalauddin Ahmed, Clement Marcellin, Ellen Shelly, Katharine Owers, Natasha Wenzel, Alison P. Galvani, John S. Brownstein

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003977

Risk Factors for Death from Visceral Leishmaniasis in an Urban Area of Brazil

Angelita F. Druzian, Albert S. de Souza, Diogo N. de Campos, Julio Croda, Minoru G. Higa Jr, Maria Elizabeth C. Dorval, Mauricio A. Pompilio, Polliana A. de Oliveira, Anamaria M. M. Paniago

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003982

Reconstructing Colonization Dynamics of the Human Parasite Schistosoma mansoni following Anthropogenic Environmental Changes in Northwest Senegal

Frederik Van den Broeck, Gregory E. Maes, Maarten H. D. Larmuseau, David Rollinson, Ibrahima Sy, Djibril Faye, Filip A. M. Volckaert, Katja Polman, Tine Huyse

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0003998

Meteorologically Driven Simulations of Dengue Epidemics in San Juan, PR

Cory W. Morin, Andrew J. Monaghan, Mary H. Hayden, Roberto Barrera, Kacey Ernst

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0004002

Use of Recombinant Virus Replicon Particles for Vaccination against Mycobacterium ulcerans Disease

Miriam Bolz, Sarah Kerber, Gert Zimmer, Gerd Pluschke

PLOS Neglected Tropical Diseases: published August 14, 2015 | https://doi.org/10.1371/journal.pntd.0004011

Selamectin Is the Avermectin with the Best Potential for Buruli Ulcer Treatment

Nicole Scherr, Gerd Pluschke, Charles J. Thompson, Santiago Ramón-García

PLOS Neglected Tropical Diseases: published August 13, 2015 | https://doi.org/10.1371/journal.pntd.0003996

Assessment of the Impact of Potential Tetracycline Exposure on the Phenotype of Aedes aegypti OX513A: Implications for Field Use

Zoe Curtis, Kelly Matzen, Marco Neira Oviedo, Derric Nimmo, Pamela Gray, Peter Winskill, Marco A. F. Locatelli, Wilson F. Jardim, Simon Warner, Luke Alphey, Camilla Beech

PLOS Neglected Tropical Diseases: published August 13, 2015 | https://doi.org/10.1371/journal.pntd.0003999

Reducing Human-Tsetse Contact Significantly Enhances the Efficacy of Sleeping Sickness Active Screening Campaigns: A Promising Result in the Context of Elimination

Fabrice Courtin, Mamadou Camara, Jean-Baptiste Rayaisse, Moise Kagbadouno, Emilie Dama, Oumou Camara, Ibrahima S. Traoré, Jérémi Rouamba, Moana Peylhard, Martin B. Somda, Mamadou Leno, Mike J. Lehane, Steve J. Torr, Philippe Solano, Vincent Jamonneau, Bruno Bucheton

PLOS Neglected Tropical Diseases: published August 12, 2015 | https://doi.org/10.1371/journal.pntd.0003727

Tsetse Control and Gambian Sleeping Sickness; Implications for Control Strategy

Inaki Tirados, Johan Esterhuizen, Vanja Kovacic, T. N. Clement Mangwiro, Glyn A. Vale, Ian Hastings, Philippe Solano, Michael J. Lehane, Steve J. Torr

PLOS Neglected Tropical Diseases: published August 12, 2015 | https://doi.org/10.1371/journal.pntd.0003822

Viral Co-infection and Leprosy Outcomes: A Cohort Study

Paulo R. L. Machado, Lídia M. Machado, Mayume Shibuya, Jamile Rego, Warren D. Johnson, Marshall J. Glesby

PLOS Neglected Tropical Diseases: published August 12, 2015 | https://doi.org/10.1371/journal.pntd.0003865

Practices of Dengue Fever Prevention and the Associated Factors among the Orang Asli in Peninsular Malaysia

Josephine Rebecca Chandren, Li Ping Wong, Sazaly AbuBakar

PLOS Neglected Tropical Diseases: published August 12, 2015 | https://doi.org/10.1371/journal.pntd.0003954

Global Gene Expression Profiling through the Complete Life Cycle of Trypanosoma vivax

Andrew P. Jackson, Sophie Goyard, Dong Xia, Bernardo J. Foth, Mandy Sanders, Jonathan M. Wastling, Paola Minoprio, Matthew Berriman

PLOS Neglected Tropical Diseases: published August 12, 2015 | https://doi.org/10.1371/journal.pntd.0003975

A Randomized Controlled Trial of a Brief Intervention for Delayed Psychological Effects in Snakebite Victims

Chamara A. Wijesinghe, Shehan S. Williams, Anuradhani Kasturiratne, Nishantha Dolawaththa, Piyal Wimalaratne, Buddhika Wijewickrema, Shaluka F. Jayamanne, Geoffrey K. Isbister, Andrew H. Dawson, David G. Lalloo, H. Janaka de Silva

PLOS Neglected Tropical Diseases: published August 11, 2015 | https://doi.org/10.1371/journal.pntd.0003989

Bibliometric Assessment of European and Sub-Saharan African Research Output on Poverty-Related and Neglected Infectious Diseases from 2003 to 2011

J. Gabrielle Breugelmans, Michael M. Makanga, Ana Lúcia V. Cardoso, Sophie B. Mathewson, Bethan R. Sheridan-Jones, Karen A. Gurney, Charles S. Mgone

PLOS Neglected Tropical Diseases: published August 11, 2015 | https://doi.org/10.1371/journal.pntd.0003997

Transmission of Leishmania donovani in the Hills of Eastern Nepal, an Outbreak Investigation in Okhaldhunga and Bhojpur Districts

Bart Ostyn, Surendra Uranw, Narayan Raj Bhattarai, Murari L. Das, Keshav Rai, Katrien Tersago, Yubraj Pokhrel, Lies Durnez, Baburam Marasini, Gert Van der Auwera, Jean-Claude Dujardin, Marc Coosemans, Daniel Argaw, Marleen Boelaert, Suman Rijal

PLOS Neglected Tropical Diseases: published August 7, 2015 | https://doi.org/10.1371/journal.pntd.0003966

Determinants of Health Service Responsiveness in Community-Based Vector Surveillance for Chagas Disease in Guatemala, El Salvador, and Honduras

Ken Hashimoto, Concepción Zúniga, Eduardo Romero, Zoraida Morales, James H. Maguire

PLOS Neglected Tropical Diseases: published August 7, 2015 | https://doi.org/10.1371/journal.pntd.0003974

Taenia solium: Development of an Experimental Model of Porcine Neurocysticercosis

Agnès Fleury, Armando Trejo, Humberto Cisneros, Roberto García-Navarrete, Nelly Villalobos, Marisela Hernández, Juana Villeda Hernández, Beatriz Hernández, Gabriela Rosas, Raul J. Bobes, Aline S. de Aluja, Edda Sciutto, Gladis Fragoso

PLOS Neglected Tropical Diseases: published August 7, 2015 | https://doi.org/10.1371/journal.pntd.0003980

Adipose Tissue-Derived Mesenchymal Stromal Cells Protect Mice Infected with Trypanosoma cruzi from Cardiac Damage through Modulation of Anti-parasite Immunity

Debora B. Mello, Isalira P. Ramos, Fernanda C. P. Mesquita, Guilherme V. Brasil, Nazareth N. Rocha, Christina M. Takiya, Ana Paula C. A. Lima, Antonio C. Campos de Carvalho, Regina S. Goldenberg, Adriana B. Carvalho

PLOS Neglected Tropical Diseases: published August 6, 2015 | https://doi.org/10.1371/journal.pntd.0003945

Asymptomatic Helminth Infection in Active Tuberculosis Is Associated with Increased Regulatory and Th-2 Responses and a Lower Sputum Smear Positivity

Ebba Abate, Meseret Belayneh, Jonna Idh, Ermias Diro, Daniel Elias, Sven Britton, Abraham Aseffa, Olle Stendahl, Thomas Schön

PLOS Neglected Tropical Diseases: published August 6, 2015 | https://doi.org/10.1371/journal.pntd.0003994

Protective Enterotoxigenic Escherichia coli Antigens in a Murine Intranasal Challenge Model

Amit Kumar, Mike Hays, Francis Lim, Leonard J. Foster, Mingxu Zhou, Guoqiang Zhu, Tracy Miesner, Philip R. Hardwidge

PLOS Neglected Tropical Diseases: published August 5, 2015 | https://doi.org/10.1371/journal.pntd.0003924

Transcription Profiling of Malaria-Naïve and Semi-immune Colombian Volunteers in a Plasmodium vivax Sporozoite Challenge

Monica L. Rojas-Peña, Andres Vallejo, Sócrates Herrera, Greg Gibson, Myriam Arévalo-Herrera

PLOS Neglected Tropical Diseases: published August 5, 2015 | https://doi.org/10.1371/journal.pntd.0003978

Historical Perspective and Risk of Multiple Neglected Tropical Diseases in Coastal Tanzania: Compositional and Contextual Determinants of Disease Risk

Frederick Ato Armah, Reginald Quansah, Isaac Luginaah, Ratana Chuenpagdee, Herbert Hambati, Gwyn Campbell

PLOS Neglected Tropical Diseases: published August 4, 2015 | https://doi.org/10.1371/journal.pntd.0003939

The Right Tool for the Job: Detection of Soil-Transmitted Helminths in Areas Co-endemic for Other Helminths

Maria V. Periago, Renata C. Diniz, Simone A. Pinto, Anna Yakovleva, Rodrigo Correa-Oliveira, David J. Diemert, Jeffrey M. Bethony

PLOS Neglected Tropical Diseases: published August 4, 2015 | https://doi.org/10.1371/journal.pntd.0003967

Impact of Community Mass Treatment with Azithromycin for Trachoma Elimination on the Prevalence of Yaws

Michael Marks, Ventis Vahi, Oliver Sokana, Kai-Hua Chi, Elliot Puiahi, Georgina Kilua, Allan Pillay, Tenneth Dalipanda, Christian Bottomley, Anthony W. Solomon, David C. Mabey

PLOS Neglected Tropical Diseases: published August 4, 2015 | https://doi.org/10.1371/journal.pntd.0003988

Cover

Hippos at Tala Game Park, South Africa.

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