Table of Contents

June 2015

Two Médecins Sans Frontières employees slowly mixing the coagulant for the disinfection of highly pathogenic hospital fecal waste. Sozzi et al.

Image Credit: Sozzi et al.



It’s All about Those Bases: The Need for Incorporating Parasite Genetic Heterogeneity into the Development of Schistosome Vaccines

Alyssa M. Gleichsner, Elizabeth A. Thiele, Dennis J. Minchella

Alterations in DNA Methylation May Be the Key to Early Detection and Treatment of Schistosomal Bladder Cancer

Simon L. Conti, Jared Honeycutt, Justin I. Odegaard, Mark L. Gonzalgo, Michael H. Hsieh

Target Product Profile (TPP) for Chagas Disease Point-of-Care Diagnosis and Assessment of Response to Treatment

Analía I. Porrás, Zaida E. Yadon, Jaime Altcheh, Constança Britto, Gabriela C. Chaves, Laurence Flevaud, Olindo Assis Martins-Filho, Isabela Ribeiro, Alejandro G. Schijman, Maria Aparecida Shikanai-Yasuda, Sergio Sosa-Estani, Eric Stobbaerts, Fabio Zicker

Policy Platform

The Case for Improved Diagnostic Tools to Control Ebola Virus Disease in West Africa and How to Get There

Arlene C. Chua, Jane Cunningham, Francis Moussy, Mark D. Perkins, Pierre Formenty


Control of Dog Mediated Human Rabies in Haiti: No Time to Spare

Max F. Millien, Jocelyne B. Pierre-Louis, Ryan Wallace, Eduardo Caldas, Jean M. Rwangabgoba, Jean L. Poncelet, Ottorino Cosivi, Victor J. Del Rio Vilas

The Potential Use of Wolbachia-Based Mosquito Biocontrol Strategies for Japanese Encephalitis

Claire L. Jeffries, Thomas Walker

The Rising Dominance of Shigella sonnei: An Intercontinental Shift in the Etiology of Bacillary Dysentery

Corinne N. Thompson, Pham Thanh Duy, Stephen Baker

The Complexity of a Dengue Vaccine: A Review of the Human Antibody Response

Jacky Flipse, Jolanda M. Smit

What Factors Might Have Led to the Emergence of Ebola in West Africa?

Kathleen A. Alexander, Claire E. Sanderson, Madav Marathe, Bryan L. Lewis, Caitlin M. Rivers, Jeffrey Shaman, John M. Drake, Eric Lofgren, Virginia M. Dato, Marisa C. Eisenberg, Stephen Eubank

Research Articles

Plasmodium vivax Diversity and Population Structure across Four Continents

Cristian Koepfli, Priscila T. Rodrigues, Tiago Antao, Pamela Orjuela-Sánchez, Peter Van den Eede, Dionicia Gamboa, Nguyen van Hong, Jorge Bendezu, Annette Erhart, Céline Barnadas, Arsène Ratsimbasoa, Didier Menard, Carlo Severini, Michela Menegon, Bakri Y. M. Nour, Nadira Karunaweera, Ivo Mueller, Marcelo U. Ferreira, Ingrid Felger

Development of an Immunochromatographic Test for Diagnosis of Visceral Leishmaniasis Based on Detection of a Circulating Antigen

Chun-hua Gao, Yue-tao Yang, Feng Shi, Jun-yun Wang, Dietmar Steverding, Xia Wang

Failure of PCR to Detect Treponema pallidum ssp. pertenue DNA in Blood in Latent Yaws

Michael Marks, Samantha Katz, Kai-Hua Chi, Ventis Vahi, Yongcheng Sun, David C. Mabey, Anthony W. Solomon, Cheng Y. Chen, Allan Pillay

Identification of Burkholderia pseudomallei Near-Neighbor Species in the Northern Territory of Australia

Jennifer L. Ginther, Mark Mayo, Stephanie D. Warrington, Mirjam Kaestli, Travis Mullins, David M. Wagner, Bart J. Currie, Apichai Tuanyok, Paul Keim

A Rodent Model of Chikungunya Virus Infection in RAG1 -/- Mice, with Features of Persistence, for Vaccine Safety Evaluation

Robert L. Seymour, A. Paige Adams, Grace Leal, Maria D. H. Alcorn, Scott C. Weaver

Differences in the Faecal Microbiome in Schistosoma haematobium Infected Children vs. Uninfected Children

Gemma Louise Kay, Andrew Millard, Martin J. Sergeant, Nicholas Midzi, Reggis Gwisai, Takafira Mduluza, Alasdair Ivens, Norman Nausch, Francisca Mutapi, Mark Pallen

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Characterization of the Burkholderia mallei tonB Mutant and Its Potential as a Backbone Strain for Vaccine Development

Tiffany M. Mott, Sudhamathi Vijayakumar, Elena Sbrana, Janice J. Endsley, Alfredo G. Torres

Knowledge, Attitudes and Practices of Animal Bite Victims Attending an Anti-rabies Health Center in Jimma Town, Ethiopia

Tadele Kabeta, Benti Deresa, Worku Tigre, Michael P. Ward, Siobhan M. Mor

PKC/ROS-Mediated NLRP3 Inflammasome Activation Is Attenuated by Leishmania Zinc-Metalloprotease during Infection

Marina Tiemi Shio, Jan Gregor Christian, Jee Yong Jung, Kwang-Poo Chang, Martin Olivier

Machine Learning Models and Pathway Genome Data Base for Trypanosoma cruzi Drug Discovery

Sean Ekins, Jair Lage de Siqueira-Neto, Laura-Isobel McCall, Malabika Sarker, Maneesh Yadav, Elizabeth L. Ponder, E. Adam Kallel, Danielle Kellar, Steven Chen, Michelle Arkin, Barry A. Bunin, James H. McKerrow, Carolyn Talcott

Three Gorges Dam: Impact of Water Level Changes on the Density of Schistosome-Transmitting Snail Oncomelania hupensis in Dongting Lake Area, China

Jin-Yi Wu, Yi-Biao Zhou, Yue Chen, Song Liang, Lin-Han Li, Sheng-Bang Zheng, Shao-ping Zhu, Guang-Hui Ren, Xiu-Xia Song, Qing-Wu Jiang

Snakebites in Two Rural Districts in Lao PDR: Community-Based Surveys Disclose High Incidence of an Invisible Public Health Problem

Inthanomchanh Vongphoumy, Panom Phongmany, Sengdao Sydala, Nouda Prasith, Ralf Reintjes, Joerg Blessmann

Wolbachia Reduces the Transmission Potential of Dengue-Infected Aedes aegypti

Yixin H. Ye, Alison M. Carrasco, Francesca D. Frentiu, Stephen F. Chenoweth, Nigel W. Beebe, Andrew F. van den Hurk, Cameron P. Simmons, Scott L. O’Neill, Elizabeth A. McGraw

Minimizing the Risk of Disease Transmission in Emergency Settings: Novel In Situ Physico-Chemical Disinfection of Pathogen-Laden Hospital Wastewaters

Emanuele Sozzi, Kerline Fabre, Jean-François Fesselet, James E. Ebdon, Huw Taylor

Relationship between Distinct African Cholera Epidemics Revealed via MLVA Haplotyping of 337 Vibrio cholerae Isolates

Sandra Moore, Berthe Miwanda, Adodo Yao Sadji, Hélène Thefenne, Fakhri Jeddi, Stanislas Rebaudet, Hilde de Boeck, Bawimodom Bidjada, Jean-Jacques Depina, Didier Bompangue, Aaron Aruna Abedi, Lamine Koivogui, Sakoba Keita, Eric Garnotel, Pierre-Denis Plisnier, Raymond Ruimy, Nicholas Thomson, Jean-Jacques Muyembe, Renaud Piarroux

Genotypic Diversity Is Associated with Clinical Outcome and Phenotype in Cryptococcal Meningitis across Southern Africa

Mathew A. Beale, Wilber Sabiiti, Emma J. Robertson, Karen M. Fuentes-Cabrejo, Simon J. O’Hanlon, Joseph N. Jarvis, Angela Loyse, Graeme Meintjes, Thomas S. Harrison, Robin C. May, Matthew C. Fisher, Tihana Bicanic

Canine Antibodies against Salivary Recombinant Proteins of Phlebotomus perniciosus: A Longitudinal Study in an Endemic Focus of Canine Leishmaniasis

Tatiana Kostalova, Tereza Lestinova, Petra Sumova, Michaela Vlkova, Iva Rohousova, Eduardo Berriatua, Gaetano Oliva, Eleonora Fiorentino, Aldo Scalone, Marina Gramiccia, Luigi Gradoni, Petr Volf

Salivary Thromboxane A2-Binding Proteins from Triatomine Vectors of Chagas Disease Inhibit Platelet-Mediated Neutrophil Extracellular Traps (NETs) Formation and Arterial Thrombosis

Daniella M. Mizurini, Jorgeane S. Aslan, Tainá Gomes, Dongying Ma, Ivo M. B. Francischetti, Robson Q. Monteiro

Soil-Transmitted Helminths in Southwestern China: A Cross-Sectional Study of Links to Cognitive Ability, Nutrition, and School Performance among Children

Chengfang Liu, Renfu Luo, Hongmei Yi, Linxiu Zhang, Shaoping Li, Yunli Bai, Alexis Medina, Scott Rozelle, Scott Smith, Guofei Wang, Jujun Wang

Diagnostic Accuracy of Recombinant Immunoglobulin-like Protein A-Based IgM ELISA for the Early Diagnosis of Leptospirosis in the Philippines

Emi Kitashoji, Nobuo Koizumi, Talitha Lea V. Lacuesta, Daisuke Usuda, Maricel R. Ribo, Edith S. Tria, Winston S. Go, Maiko Kojiro, Christopher M. Parry, Efren M. Dimaano, Jose B. Villarama, Makoto Ohnishi, Motoi Suzuki, Koya Ariyoshi

Polymorphisms in the TOLLIP Gene Influence Susceptibility to Cutaneous Leishmaniasis Caused by Leishmania guyanensis in the Amazonas State of Brazil

Felipe Jules de Araujo, Luan Diego Oliveira da Silva, Tirza Gabrielle Mesquita, Suzana Kanawati Pinheiro, Wonei de Seixas Vital, Anette Chrusciak-Talhari, Jorge Augusto de Oliveira Guerra, Sinésio Talhari, Rajendranath Ramasawmy

Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta

Ricardo Ataíde, Oscar Murillo, Jamille G. Dombrowski, Rodrigo M. Souza, Flávia A. Lima, Giselle F. M. C. Lima, Angélica D. Hristov, Suiane C. N. Valle, Silvia M. Di Santi, Sabrina Epiphanio, Claudio R. F. Marinho

Interleukin (IL)-6 and IL-10 Are Up Regulated in Late Stage Trypanosoma brucei rhodesiense Sleeping Sickness

Charles D. Kato, Vincent P. Alibu, Ann Nanteza, Claire M. Mugasa, Enock Matovu

Characterization of the Invasive, Multidrug Resistant Non-typhoidal Salmonella Strain D23580 in a Murine Model of Infection

Jiseon Yang, Jennifer Barrila, Kenneth L. Roland, Jacquelyn Kilbourne, C. Mark Ott, Rebecca J. Forsyth, Cheryl A. Nickerson

Buruli Ulcer Disease and Its Association with Land Cover in Southwestern Ghana

Jianyong Wu, Petra Tschakert, Erasmus Klutse, David Ferring, Vincent Ricciardi, Heidi Hausermann, Joseph Oppong, Erica A. H. Smithwick

Trypanosoma cruzi Infection through the Oral Route Promotes a Severe Infection in Mice: New Disease Form from an Old Infection?

Juliana Barreto-de-Albuquerque, Danielle Silva-dos-Santos, Ana Rosa Pérez, Luiz Ricardo Berbert, Eliane de Santana-van-Vliet, Désio Aurélio Farias-de-Oliveira, Otacilio C. Moreira, Eduardo Roggero, Carla Eponina de Carvalho-Pinto, José Jurberg, Vinícius Cotta-de-Almeida, Oscar Bottasso, Wilson Savino, Juliana de Meis

Toward Measuring Schistosoma Response to Praziquantel Treatment with Appropriate Descriptors of Egg Excretion

Piero L. Olliaro, Michel Vaillant, Aïssatou Diawara, Jean T. Coulibaly, Amadou Garba, Jennifer Keiser, Charles H. King, Stefanie Knopp, Aly Landouré, Eliézer K. N’Goran, Giovanna Raso, Alexandra U. Scherrer, José Carlos Sousa-Figueiredo, Katarina Stete, Xiao-Nong Zhou, Jürg Utzinger

MicroRNA Transcriptome Profiling in Heart of Trypanosoma cruzi-Infected Mice: Parasitological and Cardiological Outcomes

Isabela Cunha Navarro, Frederico Moraes Ferreira, Helder I. Nakaya, Monique Andrade Baron, Gláucia Vilar-Pereira, Isabela Resende Pereira, Ana Maria Gonçalves Silva, Juliana Monte Real, Thales De Brito, Christophe Chevillard, Joseli Lannes-Vieira, Jorge Kalil, Edecio Cunha-Neto, Ludmila Rodrigues Pinto Ferreira

BoHV-4-Based Vector Single Heterologous Antigen Delivery Protects STAT1(-/-) Mice from Monkeypoxvirus Lethal Challenge

Valentina Franceschi, Scott Parker, Sarah Jacca, Ryan W. Crump, Konstantin Doronin, Edguardo Hembrador, Daniela Pompilio, Giulia Tebaldi, Ryan D. Estep, Scott W. Wong, Mark R. Buller, Gaetano Donofrio

Distinct Phenotypes Caused by Mutation of MSH2 in Trypanosome Insect and Mammalian Life Cycle Forms Are Associated with Parasite Adaptation to Oxidative Stress

Viviane Grazielle-Silva, Tehseen Fatima Zeb, Jason Bolderson, Priscila C. Campos, Julia B. Miranda, Ceres L. Alves, Carlos R. Machado, Richard McCulloch, Santuza M. R. Teixeira

Autochthonous Chikungunya Transmission and Extreme Climate Events in Southern France

David Roiz, Philippe Boussès, Frédéric Simard, Christophe Paupy, Didier Fontenille

Acceptability and Willingness-to-Pay for a Hypothetical Ebola Virus Vaccine in Nigeria

Maduka Donatus Ughasoro, Dorothy Omono Esangbedo, Beckie Nnenna Tagbo, Ijeoma Chigozie Mejeha

Diverse Genotypes of Yersinia pestis Caused Plague in Madagascar in 2007

Julia M. Riehm, Michaela Projahn, Amy J. Vogler, Minoaerisoa Rajerison, Genevieve Andersen, Carina M. Hall, Thomas Zimmermann, Rahelinirina Soanandrasana, Voahangy Andrianaivoarimanana, Reinhard K. Straubinger, Roxanne Nottingham, Paul Keim, David M. Wagner, Holger C. Scholz

Oral Wild-Type Salmonella Typhi Challenge Induces Activation of Circulating Monocytes and Dendritic Cells in Individuals Who Develop Typhoid Disease

Franklin R. Toapanta, Paula J. Bernal, Stephanie Fresnay, Thomas C. Darton, Claire Jones, Claire S. Waddington, Christoph J. Blohmke, Gordon Dougan, Brian Angus, Myron M. Levine, Andrew J. Pollard, Marcelo B. Sztein

Prioritising Infectious Disease Mapping

David M. Pigott, Rosalind E. Howes, Antoinette Wiebe, Katherine E. Battle, Nick Golding, Peter W. Gething, Scott F. Dowell, Tamer H. Farag, Andres J. Garcia, Ann M. Kimball, L. Kendall Krause, Craig H. Smith, Simon J. Brooker, Hmwe H. Kyu, Theo Vos, Christopher J. L. Murray, Catherine L. Moyes, Simon I. Hay

Airborne Transmission of Melioidosis to Humans from Environmental Aerosols Contaminated with B. pseudomallei

Pei-Shih Chen, Yao-Shen Chen, Hsi-Hsun Lin, Pei-Ju Liu, Wei-Fan Ni, Pei-Tan Hsueh, Shih-Hsiung Liang, Chialin Chen, Ya-Lei Chen

Monitoring the Progress towards the Elimination of Gambiense Human African Trypanosomiasis

Pere P. Simarro, Giuliano Cecchi, José R. Franco, Massimo Paone, Abdoulaye Diarra, Gerardo Priotto, Raffaele C. Mattioli, Jean G. Jannin

Effect of Antihelminthic Treatment on Vaccine Immunogenicity to a Seasonal Influenza Vaccine in Primary School Children in Gabon: A Randomized Placebo-Controlled Trial

Sina Brückner, Selidji T. Agnandji, Stefan Berberich, Emmanuel Bache, José F. Fernandes, Brunhilde Schweiger, Marguerite Massinga Loembe, Thomas Engleitner, Bertrand Lell, Benjamin Mordmüller, Ayola A. Adegnika, Maria Yazdanbakhsh, Peter G. Kremsner, Meral Esen

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