Table of Contents

February 2013

The photograph shows a scientist holding three prototype lateral flow tests developed with sera from two patients infected with Trypanosma brucei gambiense (left and right) and from one uninfected patient (middle). Robust, cheap, and simple methods are needed for the diagnosis of human African trypanosomiasis in the field. This device, developed by The University of Dundee and BB International, represents a step towards that goal. See Sullivan et al.

Image Credit: Lauren Sullivan


A New European Neglected Diseases Center for Greece?

Peter J. Hotez, T. Dorina Papageorgiou


The Epidemiological Relevance of Family Study in Chagas Disease

Inés Zulantay, Werner Apt, Daniel Ramos, Lorena Godoy, Claudio Valencia, Matías Molina, Eduardo Sepúlveda, Patricio Thieme, Gabriela Martínez, Gabriela Corral


Trachoma: Protective and Pathogenic Ocular Immune Responses to Chlamydia trachomatis

Victor H. Hu, Martin J. Holland, Matthew J. Burton

Research Articles

How Effective Is School-Based Deworming for the Community-Wide Control of Soil-Transmitted Helminths?

Roy M. Anderson, James E. Truscott, Rachel L. Pullan, Simon J. Brooker, T. Deirdre Hollingsworth

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Molecular Epidemiology and Antibiotic Susceptibility of Livestock Brucella melitensis Isolates from Naryn Oblast, Kyrgyzstan

Joldoshbek Kasymbekov, Joldoshbek Imanseitov, Marie Ballif, Nadia Schürch, Sandra Paniga, Paola Pilo, Mauro Tonolla, Cinzia Benagli, Kulyash Akylbekova, Zarima Jumakanova, Esther Schelling, Jakob Zinsstag

New Approaches with Different Types of Circulating Cathodic Antigen for the Diagnosis of Patients with Low Schistosoma mansoni Load

Rafaella Grenfell, Donald A. Harn, Smanla Tundup, Akram Da'dara, Liliane Siqueira, Paulo Marcos Zech Coelho

Differential Expression of Toll-like Receptors in Dendritic Cells of Patients with Dengue during Early and Late Acute Phases of the Disease

Silvia Torres, Juan Carlos Hernández, Diana Giraldo, Margarita Arboleda, Mauricio Rojas, Jolanda M. Smit, Silvio Urcuqui-Inchima

The Household Costs of Visceral Leishmaniasis Care in South-eastern Nepal

Surendra Uranw, Filip Meheus, Rob Baltussen, Suman Rijal, Marleen Boelaert

Standardizing Visual Control Devices for Tsetse Flies: East African Species Glossina swynnertoni

Furaha Mramba, Francis Oloo, Mechtilda Byamungu, Thomas Kröber, Andrew McMullin, Steve Mihok, Patrick M. Guerin

Serological Evidence of Rift Valley Fever Virus Circulation in Sheep and Goats in Zambézia Province, Mozambique

José Fafetine, Luis Neves, Peter N. Thompson, Janusz T. Paweska, Victor P. M. G. Rutten, J. A. W. Coetzer

Using Serology to Assist with Complicated Post-Exposure Prophylaxis for Rabies and Australian Bat Lyssavirus

Niall Conroy, Susan Vlack, Julian M. Williams, John J. Patten, Robert L. Horvath, Stephen B. Lambert

Contact Irritant Responses of Aedes aegypti Using Sublethal Concentration and Focal Application of Pyrethroid Chemicals

Hortance Manda, Pankhil Shah, Suppaluck Polsomboon, Theeraphap Chareonviriyaphap, Fanny Castro-Llanos, Amy Morrison, Roxanne G. Burrus, John P. Grieco, Nicole L. Achee

Rabies in Iraq: Trends in Human Cases 2001–2010 and Characterisation of Animal Rabies Strains from Baghdad

Daniel L. Horton, Mashair Z. Ismail, Eman S. Siryan, Abdul Raheem A. Wali, Husam E. Ab-dulla, Emma Wise, Katja Voller, Graeme Harkess, Denise A. Marston, Lorraine M. McElhinney, Salah F. Abbas, Anthony R. Fooks

HLA-A2 and B35 Restricted Hantaan Virus Nucleoprotein CD8+ T-Cell Epitope-Specific Immune Response Correlates with Milder Disease in Hemorrhagic Fever with Renal Syndrome

Ying Ma, Jiuping Wang, Bin Yuan, Meiliang Wang, Yun Zhang, Zhuwei Xu, Chunmei Zhang, Yusi Zhang, Bei Liu, Jing Yi, Kun Yang, Angang Yang, Ran Zhuang, Boquan Jin

Electrocardiographic Abnormalities in Trypanosoma cruzi Seropositive and Seronegative Former Blood Donors

Antonio L. Ribeiro, Ester C. Sabino, Milena S. Marcolino, Vera M. C. Salemi, Barbara M. Ianni, Fábio Fernandes, Luciano Nastari, André Antunes, Márcia Menezes, Cláudia Di Lorenzo Oliveira, Vandana Sachdev, Danielle M. Carrick, Michael P. Busch, Eduard L. Murphy, for the NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component

Toll-like Receptor Signaling Activation by Entamoeba histolytica Induces Beta Defensin 2 in Human Colonic Epithelial Cells: Its Possible Role as an Element of the Innate Immune Response

Jorge-Tonatiuh Ayala-Sumuano, Victor M. Téllez-López, M. del Carmen Domínguez-Robles, Mineko Shibayama-Salas, Isaura Meza

Dynamics of Onchocerca volvulus Microfilarial Densities after Ivermectin Treatment in an Ivermectin-naïve and a Multiply Treated Population from Cameroon

Sébastien D. S. Pion, Hugues C. Nana-Djeunga, Joseph Kamgno, Nicholas Tendongfor, Samuel Wanji, Flobert Njiokou, Roger K. Prichard, Michel Boussinesq

Bactericidal Activity Does Not Predict Sterilizing Activity: The Case of Rifapentine in the Murine Model of Mycobacterium ulcerans Disease

Deepak V. Almeida, Paul J. Converse, Si-Yang Li, Sandeep Tyagi, Eric L. Nuermberger, Jacques H. Grosset

A Neglected Aspect of the Epidemiology of Sleeping Sickness: The Propensity of the Tsetse Fly Vector to Enter Houses

Glyn A. Vale, Andrew Chamisa, Clement Mangwiro, Stephen J. Torr

Proteomic Selection of Immunodiagnostic Antigens for Human African Trypanosomiasis and Generation of a Prototype Lateral Flow Immunodiagnostic Device

Lauren Sullivan, Steven J. Wall, Mark Carrington, Michael A. J. Ferguson

Neopterin Is a Cerebrospinal Fluid Marker for Treatment Outcome Evaluation in Patients Affected by Trypanosoma brucei gambiense Sleeping Sickness

Natalia Tiberti, Veerle Lejon, Alexandre Hainard, Bertrand Courtioux, Xavier Robin, Natacha Turck, Krister Kristensson, Enock Matovu, John Charles Enyaru, Dieudonné Mumba Ngoyi, Sanjeev Krishna, Sylvie Bisser, Joseph Mathu Ndung′u, Philippe Büscher, Jean-Charles Sanchez

Molecular Epidemiology of Human Oral Chagas Disease Outbreaks in Colombia

Juan David Ramírez, Marleny Montilla, Zulma M. Cucunubá, Astrid Carolina Floréz, Pilar Zambrano, Felipe Guhl

Economic and Disease Burden of Dengue in Southeast Asia

Donald S. Shepard, Eduardo A. Undurraga, Yara A. Halasa

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Use of Expansion Factors to Estimate the Burden of Dengue in Southeast Asia: A Systematic Analysis

Eduardo A. Undurraga, Yara A. Halasa, Donald S. Shepard

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A Newly Emerged Cutaneous Leishmaniasis Focus in Northern Israel and Two New Reservoir Hosts of Leishmania major

Roy Faiman, Ibrahim Abbasi, Charles Jaffe, Yoav Motro, Abdelmagid Nasereddin, Lionel F. Schnur, Moshe Torem, Francine Pratlong, Jean-Pierre Dedet, Alon Warburg

T Cell Hypo-Responsiveness against Leishmania major in MAP Kinase Phosphatase (MKP) 2 Deficient C57BL/6 Mice Does Not Alter the Healer Disease Phenotype

Juliane Schroeder, H. Adrienne McGachy, Stuart Woods, Robin Plevin, James Alexander

Trypanosoma cruzi I and IV Stocks from Brazilian Amazon Are Divergent in Terms of Biological and Medical Properties in Mice

Wuelton Marcelo Monteiro, Ana Paula Margioto Teston, Ana Paula Gruendling, Daniele dos Reis, Mônica Lúcia Gomes, Silvana Marques de Araújo, Maria Terezinha Bahia, Laylah Kelre Costa Magalhães, Jorge Augusto de Oliveira Guerra, Henrique Silveira, Max Jean de Ornelas Toledo, Maria das Graças Vale Barbosa

Regional, Household and Individual Factors that Influence Soil Transmitted Helminth Reinfection Dynamics in Preschool Children from Rural Indigenous Panamá

Carli M. Halpenny, Claire Paller, Kristine G. Koski, Victoria E. Valdés, Marilyn E. Scott

Activities of Daily Living Associated with Acquisition of Melioidosis in Northeast Thailand: A Matched Case-Control Study

Direk Limmathurotsakul, Manas Kanoksil, Vanaporn Wuthiekanun, Rungrueng Kitphati, Bianca deStavola, Nicholas P. J. Day, Sharon J. Peacock

High Content Screening of a Kinase-Focused Library Reveals Compounds Broadly-Active against Dengue Viruses

Deu John M. Cruz, Andrea Cristine Koishi, Juliana Bosso Taniguchi, Xiaolan Li, Rafaela Milan Bonotto, Joo Hwan No, Keum Hyun Kim, Sungmin Baek, Hee Young Kim, Marc Peter Windisch, Ana Luiza Pamplona Mosimann, Luana de Borba, Michel Liuzzi, Michael Adsetts Edberg Hansen, Claudia Nunes Duarte dos Santos, Lucio Holanda Freitas-Junior

UCP2 Deficiency Helps to Restrict the Pathogenesis of Experimental Cutaneous and Visceral Leishmaniosis in Mice

Javier Carrión, M. Angeles Abengozar, María Fernández-Reyes, Carlos Sánchez-Martín, Eduardo Rial, Gustavo Domínguez-Bernal, M. Mar González-Barroso

Time Series Analysis of Onchocerciasis Data from Mexico: A Trend towards Elimination

Edgar E. Lara-Ramírez, Mario A. Rodríguez-Pérez, Miguel A. Pérez-Rodríguez, Monsuru A. Adeleke, María E. Orozco-Algarra, Juan I. Arrendondo-Jiménez, Xianwu Guo

Development and Validation of a Novel Diagnostic Test for Human Brucellosis Using a Glyco-engineered Antigen Coupled to Magnetic Beads

Andrés E. Ciocchini, Diego A. Rey Serantes, Luciano J. Melli, Jeremy A. Iwashkiw, Bettina Deodato, Jorge Wallach, Mario F. Feldman, Juan E. Ugalde, Diego J. Comerci

Cholera Outbreaks in Nigeria Are Associated with Multidrug Resistant Atypical El Tor and Non-O1/Non-O139 Vibrio cholerae

Michel A. Marin, Cristiane C. Thompson, Fernanda S. Freitas, Erica L. Fonseca, A. Oladipo Aboderin, Sambo B. Zailani, Naa Kwarley E. Quartey, Iruka N. Okeke, Ana Carolina P. Vicente

Mosquito Cellular Factors and Functions in Mediating the Infectious entry of Chikungunya Virus

Regina Ching Hua Lee, Hapuarachchige Chanditha Hapuarachchi, Karen Caiyun Chen, Khairunnisa' Mohamed Hussain, Huixin Chen, Swee Ling Low, Lee Ching Ng, Raymond Lin, Mary Mah-Lee Ng, Justin Jang Hann Chu

An Integrated Linkage, Chromosome, and Genome Map for the Yellow Fever Mosquito Aedes aegypti

Vladimir A. Timoshevskiy, David W. Severson, Becky S. deBruyn, William C. Black, Igor V. Sharakhov, Maria V. Sharakhova

Latent Infection with Leishmania donovani in Highly Endemic Villages in Bihar, India

Epco Hasker, Sangeeta Kansal, Paritosh Malaviya, Kamlesh Gidwani, Albert Picado, Rudra Pratap Singh, Ankita Chourasia, Abhishek Kumar Singh, Ravi Shankar, Joris Menten, Mary Elizabeth Wilson, Marleen Boelaert, Shyam Sundar

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Cross-reactive Neutralizing Antibody Responses to Enterovirus 71 Infections in Young Children: Implications for Vaccine Development

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Expansion in CD39+ CD4+ Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications

Fabio E. Leal, Lishomwa C. Ndhlovu, Aaron M. Hasenkrug, Fernanda R. Bruno, Karina I. Carvalho, Harry Wynn-Williams, Walter K. Neto, Sabri S. Sanabani, Aluisio C. Segurado, Douglas F. Nixon, Esper G. Kallas

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