Table of Contents

February 2012

Parasitic flatworms of the genus Schistosoma cause disease when their eggs become trapped in host organs and elicit immune responses that result in tissue damage. A remarkable aspect of schistosome biology is that females remain reproductively mature only when paired with males in vivo. Galanti et al. show that failure to make eggs in the absence of males, or in vitro, is due to apoptosis within the vitellarium, a proliferative organ that produces vitelline cells, an essential component of the egg. Understanding schistosome reproduction may offer opportunities to prevent transmission and disease.

Image Credit: Sarah Galanti


Improving Access to Medicines for Neglected Tropical Diseases in Developing Countries: Lessons from Three Emerging Economies

Francesca Holt, Stephen J. Gillam, Jeremiah M. Ngondi

From Innovation to Application

The Blueprint for Rabies Prevention and Control: A Novel Operational Toolkit for Rabies Elimination

Tiziana Lembo, on behalf of the Partners for Rabies Prevention


Toxocariasis in Cuba: A Literature Review

Idalia Sariego, Kirezi Kanobana, Lázara Rojas, Niko Speybroeck, Katja Polman, Fidel A. Núñez

Research Articles

Genetic Characterization of Zika Virus Strains: Geographic Expansion of the Asian Lineage

Andrew D. Haddow, Amy J. Schuh, Chadwick Y. Yasuda, Matthew R. Kasper, Vireak Heang, Rekol Huy, Hilda Guzman, Robert B. Tesh, Scott C. Weaver

Development and Characterization of a Reverse Genetic System for Studying Dengue Virus Serotype 3 Strain Variation and Neutralization

William B. Messer, Boyd Yount, Kari E. Hacker, Eric F. Donaldson, Jeremy P. Huynh, Aravinda M. de Silva, Ralph S. Baric

The Transcriptome Analysis of Strongyloides stercoralis L3i Larvae Reveals Targets for Intervention in a Neglected Disease

Antonio Marcilla, Gagan Garg, Dolores Bernal, Shoba Ranganathan, Javier Forment, Javier Ortiz, Carla Muñoz-Antolí, M. Victoria Dominguez, Laia Pedrola, Juan Martinez-Blanch, Javier Sotillo, Maria Trelis, Rafael Toledo, J. Guillermo Esteban

Molecular Mechanisms of Drug Resistance in Natural Leishmania Populations Vary with Genetic Background

Saskia Decuypere, Manu Vanaerschot, Kirstyn Brunker, Hideo Imamura, Sylke Müller, Basudha Khanal, Suman Rijal, Jean-Claude Dujardin, Graham H. Coombs

Therapeutic DNA Vaccine Encoding Peptide P10 against Experimental Paracoccidioidomycosis

Glauce M. G. Rittner, Julián E. Muñoz, Alexandre F. Marques, Joshua D. Nosanchuk, Carlos P. Taborda, Luiz R. Travassos

Dengue Infection in Children in Ratchaburi, Thailand: A Cohort Study. II. Clinical Manifestations

Chukiat Sirivichayakul, Kriengsak Limkittikul, Pornthep Chanthavanich, Vithaya Jiwariyavej, Watcharee Chokejindachai, Krisana Pengsaa, Saravudh Suvannadabba, Wut Dulyachai, G. William Letson, Arunee Sabchareon

A Novel G Protein-Coupled Receptor of Schistosoma mansoni (SmGPR-3) Is Activated by Dopamine and Is Widely Expressed in the Nervous System

Fouad El-Shehabi, Amira Taman, Lorena S. Moali, Nelly El-Sakkary, Paula Ribeiro

Regulation of Global Gene Expression in Human Loa loa Infection Is a Function of Chronicity

Cathy Steel, Sudhir Varma, Thomas B. Nutman

Chemotactic and Inflammatory Responses in the Liver and Brain Are Associated with Pathogenesis of Rift Valley Fever Virus Infection in the Mouse

Kimberly K. Gray, Melissa N. Worthy, Terry L. Juelich, Stacy L. Agar, Allison Poussard, Dan Ragland, Alexander N. Freiberg, Michael R. Holbrook

High-Resolution Melting (HRM) of the Cytochrome B Gene: A Powerful Approach to Identify Blood-Meal Sources in Chagas Disease Vectors

Victor H. Peña, Geysson J. Fernández, Andrés M. Gómez-Palacio, Ana M. Mejía-Jaramillo, Omar Cantillo, Omar Triana-Chávez

Premolis semirufa (Walker, 1856) Envenomation, Disease Affecting Rubber Tappers of the Amazon: Searching for Caterpillar-Bristles Toxic Components

Isadora Maria Villas-Boas, Rute Maria Gonçalves-de-Andrade, Giselle Pidde-Queiroz, Suely Lucia Muro Rais Assaf, Fernanda C. V. Portaro, Osvaldo A. Sant'Anna, Carmen W. van den Berg, Denise V. Tambourgi

Eliminating Rabies in Estonia

Florence Cliquet, Emmanuelle Robardet, Kylli Must, Marjana Laine, Katrin Peik, Evelyne Picard-Meyer, Anne-Laure Guiot, Enel Niin

Dengue Virus Infection-Enhancing Activity in Serum Samples with Neutralizing Activity as Determined by Using FcγR-Expressing Cells

Meng Ling Moi, Chang-Kweng Lim, Kaw Bing Chua, Tomohiko Takasaki, Ichiro Kurane

Predictive Models for the Diagnostic of Human Visceral Leishmaniasis in Brazil

Tália S. Machado de Assis, Ana Rabello, Guilherme L. Werneck

Glycoinositolphospholipids from Leishmania braziliensis and L. infantum: Modulation of Innate Immune System and Variations in Carbohydrate Structure

Rafael Ramiro Assis, Izabela Coimbra Ibraim, Fátima Soares Noronha, Salvatore Joseph Turco, Rodrigo Pedro Soares

The Genome of Mycobacterium Africanum West African 2 Reveals a Lineage-Specific Locus and Genome Erosion Common to the M. tuberculosis Complex

Stephen D. Bentley, Iñaki Comas, Josephine M. Bryant, Danielle Walker, Noel H. Smith, Simon R. Harris, Scott Thurston, Sebastien Gagneux, Jonathan Wood, Martin Antonio, Michael A. Quail, Florian Gehre, Richard A. Adegbola, Julian Parkhill, Bouke C. de Jong

Biochemical, Mutational and In Silico Structural Evidence for a Functional Dimeric Form of the Ornithine Decarboxylase from Entamoeba histolytica

Preeti, Satya Tapas, Pravindra Kumar, Rentala Madhubala, Shailly Tomar

Spatial Dimensions of Dengue Virus Transmission across Interepidemic and Epidemic Periods in Iquitos, Peru (1999–2003)

Kelly A. Liebman, Steven T. Stoddard, Amy C. Morrison, Claudio Rocha, Sharon Minnick, Moises Sihuincha, Kevin L. Russell, James G. Olson, Patrick J. Blair, Douglas M. Watts, Tadeusz Kochel, Thomas W. Scott

Evaluation of the Human IgG Antibody Response to Aedes albopictus Saliva as a New Specific Biomarker of Exposure to Vector Bites

Souleymane Doucoure, François Mouchet, Sylvie Cornelie, Jean Sébastien DeHecq, Abdul Hamid Rutee, Yelin Roca, Annie Walter, Jean Pierre Hervé, Dorothée Misse, François Favier, Philippe Gasque, Franck Remoue

Association of Mast Cell-Derived VEGF and Proteases in Dengue Shock Syndrome

Takahisa Furuta, Lyre Anni Murao, Nguyen Thi Phuong Lan, Nguyen Tien Huy, Vu Thi Que Huong, Tran Thi Thuy, Vo Dinh Tham, Cao Thi Phi Nga, Tran Thi Ngoc Ha, Yasukazu Ohmoto, Mihoko Kikuchi, Kouichi Morita, Michio Yasunami, Kenji Hirayama, Naohiro Watanabe

Cell Death and Reproductive Regression in Female Schistosoma mansoni

Sarah E. Galanti, Stanley Ching-Cheng Huang, Edward J. Pearce

Excretory/Secretory-Products of Echinococcus multilocularis Larvae Induce Apoptosis and Tolerogenic Properties in Dendritic Cells In Vitro

Justin Komguep Nono, Katrien Pletinckx, Manfred B. Lutz, Klaus Brehm

Estimating the Non-Monetary Burden of Neurocysticercosis in Mexico

Rachana Bhattarai, Christine M. Budke, Hélène Carabin, Jefferson V. Proaño, Jose Flores-Rivera, Teresa Corona, Renata Ivanek, Karen F. Snowden, Ana Flisser

Envenomations by Bothrops and Crotalus Snakes Induce the Release of Mitochondrial Alarmins

Irene Zornetta, Paola Caccin, Julián Fernandez, Bruno Lomonte, José María Gutierrez, Cesare Montecucco

First Human Rabies Case in French Guiana, 2008: Epidemiological Investigation and Control

Jean-Baptiste Meynard, Claude Flamand, Céline Dupuy, Aba Mahamat, Françoise Eltges, Frederic Queuche, Julien Renner, Jean-Michel Fontanella, Didier Hommel, Philippe Dussart, Claire Grangier, Félix Djossou, Laurent Dacheux, Maryvonne Goudal, Franck Berger, Vanessa Ardillon, Nicolas Krieger, Hervé Bourhy, André Spiegel

Clear Genetic Distinctiveness between Human- and Pig-Derived Trichuris Based on Analyses of Mitochondrial Datasets

Guo-Hua Liu, Robin B. Gasser, Ang Su, Peter Nejsum, Lifei Peng, Rui-Qing Lin, Ming-Wei Li, Min-Jun Xu, Xing-Quan Zhu

Climate-Based Models for Understanding and Forecasting Dengue Epidemics

Elodie Descloux, Morgan Mangeas, Christophe Eugène Menkes, Matthieu Lengaigne, Anne Leroy, Temaui Tehei, Laurent Guillaumot, Magali Teurlai, Ann-Claire Gourinat, Justus Benzler, Anne Pfannstiel, Jean-Paul Grangeon, Nicolas Degallier, Xavier De Lamballerie

Antischistosomal Activity of Trioxaquines: In Vivo Efficacy and Mechanism of Action on Schistosoma mansoni

Julien Portela, Jérôme Boissier, Benjamin Gourbal, Vincent Pradines, Vincent Collière, Frédéric Coslédan, Bernard Meunier, Anne Robert

Incidence Rates of Enterovirus 71 Infections in Young Children during a Nationwide Epidemic in Taiwan, 2008–09

Min-Shi Lee, Pai-Shan Chiang, Shu-Ting Luo, Mei-Liang Huang, Guan-Yuan Liou, Kuo-Chien Tsao, Tzou-Yien Lin

Spatial Distribution of, and Risk Factors for, Opisthorchis viverrini Infection in Southern Lao PDR

Armelle Forrer, Somphou Sayasone, Penelope Vounatsou, Youthanavanh Vonghachack, Dalouny Bouakhasith, Steffen Vogt, Rüdiger Glaser, Jürg Utzinger, Kongsap Akkhavong, Peter Odermatt

Global Distribution of Outbreaks of Water-Associated Infectious Diseases

Kun Yang, Jeffrey LeJeune, Doug Alsdorf, Bo Lu, C. K. Shum, Song Liang

Standardizing Visual Control Devices for Tsetse Flies: West African Species Glossina tachinoides, G. palpalis gambiensis and G. morsitans submorsitans

Jean-Baptiste Rayaisse, Thomas Kröber, Andrew McMullin, Philippe Solano, Steve Mihok, Patrick M. Guerin

NADPH Phagocyte Oxidase Knockout Mice Control Trypanosoma cruzi Proliferation, but Develop Circulatory Collapse and Succumb to Infection

Helton C. Santiago, Claudia Z. Gonzalez Lombana, Juan P. Macedo, Lara Utsch, Wagner L. Tafuri, Maria José Campagnole-Santos, Rosana O. Alves, José C. F. Alves-Filho, Alvaro J. Romanha, Fernando Queiroz Cunha, Mauro M. Teixeira, Rafael Radi, Leda Q. Vieira

Diversification of Schistosoma japonicum in Mainland China Revealed by Mitochondrial DNA

Qin Ping Zhao, Ming Sen Jiang, Hui Fen Dong, Pin Nie

Multilocus Microsatellite Typing (MLMT) of Strains from Turkey and Cyprus Reveals a Novel Monophyletic L. donovani Sensu Lato Group

Evi Gouzelou, Christos Haralambous, Ahmad Amro, Andreas Mentis, Francine Pratlong, Jean-Pierre Dedet, Jan Votypka, Petr Volf, Seray Ozensoy Toz, Katrin Kuhls, Gabriele Schönian, Ketty Soteriadou

Epidemiology of Mortality Related to Chagas' Disease in Brazil, 1999–2007

Francisco Rogerlândio Martins-Melo, Carlos Henrique Alencar, Alberto Novaes Ramos Jr., Jorg Heukelbach

Multiple Mutations in Heterogeneous Miltefosine-Resistant Leishmania major Population as Determined by Whole Genome Sequencing

Adriano C. Coelho, Sébastien Boisvert, Angana Mukherjee, Philippe Leprohon, Jacques Corbeil, Marc Ouellette

The Influence of Sex and Fly Species on the Development of Trypanosomes in Tsetse Flies

Lori Peacock, Vanessa Ferris, Mick Bailey, Wendy Gibson

Clinical Forms of Chikungunya in Gabon, 2010

Dieudonné Nkoghe, Roland Fabrice Kassa, Mélanie Caron, Gilda Grard, Illich Mombo, Branly Bikié, Christophe Paupy, Pierre Becquart, Ulrich Bisvigou, Eric Maurice Leroy

Actigraphy in Human African Trypanosomiasis as a Tool for Objective Clinical Evaluation and Monitoring: A Pilot Study

Alfred K. Njamnshi, Paul F. Seke Etet, Stephen Perrig, Alphonse Acho, Julius Y. Funsah, Dieudonné Mumba, Jean-Jacques Muyembe, Krister Kristensson, Marina Bentivoglio

An Encapsulated Yersinia pseudotuberculosis Is a Highly Efficient Vaccine against Pneumonic Plague

Anne Derbise, Alba Cerdà Marín, Patrick Ave, Thierry Blisnick, Michel Huerre, Elisabeth Carniel, Christian E. Demeure

Virus Identification in Unknown Tropical Febrile Illness Cases Using Deep Sequencing

Nathan L. Yozwiak, Peter Skewes-Cox, Mark D. Stenglein, Angel Balmaseda, Eva Harris, Joseph L. DeRisi

Schistosoma mansoni Venom Allergen Like Proteins Present Differential Allergic Responses in a Murine Model of Airway Inflammation

Leonardo Paiva Farias, Dunia Rodrigues, Vinicius Cunna, Henrique Krambeck Rofatto, Eliana L. Faquim-Mauro, Luciana C. C. Leite

Early Clinical Manifestations Associated with Death from Visceral Leishmaniasis

Valdelaine Etelvina Miranda de Araújo, Maria Helena Franco Morais, Ilka Afonso Reis, Ana Rabello, Mariângela Carneiro

Epidemiological and Genetic Data Supporting the Transmission of Ancylostoma ceylanicum among Human and Domestic Animals

Romano Ngui, Yvonne A. L. Lim, Rebecca Traub, Rohela Mahmud, Mohd Sani Mistam

Human Echinococcosis Mortality in the United States, 1990–2007

Benjamin N. Bristow, Sun Lee, Shira Shafir, Frank Sorvillo