February 2011

Providing access to diagnosis of affected population through mass screening in disease-endemic areas by mobile teams and subsequent treatment has been the basis of the methodology to reduce transmission of human African trypanosomiasis (see Simarro et al., 10.1371/journal.pntd.0001007).

Image Credit: Pere P. Simarro, World Health Organization

Editorial

Sleeping Sickness Elimination in Sight: Time to Celebrate and Reflect, but Not Relax

Serap Aksoy

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0001008

Viewpoints

Factory Tsetse Flies Must Behave Like Wild Flies: A Prerequisite for the Sterile Insect Technique

Marc J. B. Vreysen, Khalfan M. Saleh, Renaud Lancelot, Jérémy Bouyer

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0000907

The Human African Trypanosomiasis Control and Surveillance Programme of the World Health Organization 2000–2009: The Way Forward

Pere P. Simarro, Abdoulaye Diarra, Jose A. Ruiz Postigo, José R. Franco, Jean G. Jannin

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0001007

Photo Quiz

A Latin American Man with Palpitations, Dizziness, Episodes of Nonsustained Ventricular Tachycardia, and an Apical Aneurysm

Anis Rassi Jr, Anis Rassi, Carlos Franco-Paredes

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0000852

Research Articles

Clinically Unapparent Infantile Thiamin Deficiency in Vientiane, Laos

Sengmanivong Khounnorath, Karen Chamberlain, Ann M. Taylor, Douangdao Soukaloun, Mayfong Mayxay, Sue J. Lee, Bounthom Phengdy, Khonsavanh Luangxay, Kongkham Sisouk, Bandit Soumphonphakdy, Khaysy Latsavong, Kongsin Akkhavong, Nicholas J. White, Paul N. Newton

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0000969

A History of Chagas Disease Transmission, Control, and Re-Emergence in Peri-Rural La Joya, Peru

Stephen Delgado, Ricardo Castillo Neyra, Víctor R. Quispe Machaca, Jenny Ancca Juárez, Lily Chou Chu, Manuela Renee Verastegui, Giovanna M. Moscoso Apaza, César D. Bocángel, Aaron W. Tustin, Charles R. Sterling, Andrew C. Comrie, César Náquira, Juan G. Cornejo del Carpio, Robert H. Gilman, Caryn Bern, Michael Z. Levy

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0000970

Erythrocyte Transketolase Activity, Markers of Cardiac Dysfunction and the Diagnosis of Infantile Beriberi

Douangdao Soukaloun, Sue J. Lee, Karen Chamberlain, Ann M. Taylor, Mayfong Mayxay, Kongkham Sisouk, Bandit Soumphonphakdy, Khaysy Latsavong, Kongsin Akkhavong, Douangkham Phommachanh, Vanmaly Sengmeuang, Khonsavanh Luangxay, Theresa McDonagh, Nicholas J. White, Paul N. Newton

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0000971

Diagnostic Accuracy of PCR in gambiense Sleeping Sickness Diagnosis, Staging and Post-Treatment Follow-Up: A 2-year Longitudinal Study

Stijn Deborggraeve, Veerle Lejon, Rosine Ali Ekangu, Dieudonné Mumba Ngoyi, Patient Pati Pyana, Médard Ilunga, Jean Pierre Mulunda, Philippe Büscher

PLOS Neglected Tropical Diseases: published February 22, 2011 | https://doi.org/10.1371/journal.pntd.0000972

Mapping Protein Interactions between Dengue Virus and Its Human and Insect Hosts

Janet M. Doolittle, Shawn M. Gomez

PLOS Neglected Tropical Diseases: published February 15, 2011 | https://doi.org/10.1371/journal.pntd.0000954

Identification of Small Molecule Lead Compounds for Visceral Leishmaniasis Using a Novel Ex Vivo Splenic Explant Model System

Yaneth Osorio, Bruno L. Travi, Adam R. Renslo, Alex G. Peniche, Peter C. Melby

PLOS Neglected Tropical Diseases: published February 15, 2011 | https://doi.org/10.1371/journal.pntd.0000962

Elimination of Neglected Diseases in Latin America and the Caribbean: A Mapping of Selected Diseases

Maria Cristina Schneider, Ximena Paz Aguilera, Jarbas Barbosa da Silva Junior, Steven Kenyon Ault, Patricia Najera, Julio Martinez, Raquel Requejo, Ruben Santiago Nicholls, Zaida Yadon, Juan Carlos Silva, Luis Fernando Leanes, Mirta Roses Periago

PLOS Neglected Tropical Diseases: published February 15, 2011 | https://doi.org/10.1371/journal.pntd.0000964

Quantifying Quality of Life and Disability of Patients with Advanced Schistosomiasis Japonica

Tie-Wu Jia, Jürg Utzinger, Yao Deng, Kun Yang, Yi-Yi Li, Jin-Huan Zhu, Charles H. King, Xiao-Nong Zhou

PLOS Neglected Tropical Diseases: published February 15, 2011 | https://doi.org/10.1371/journal.pntd.0000966

A Coproantigen Diagnostic Test for Strongyloides Infection

Alex M. Sykes, James S. McCarthy

PLOS Neglected Tropical Diseases: published February 8, 2011 | https://doi.org/10.1371/journal.pntd.0000955

2,4-Diaminopyrimidines as Potent Inhibitors of Trypanosoma brucei and Identification of Molecular Targets by a Chemical Proteomics Approach

Luke Mercer, Tana Bowling, Joe Perales, Jennifer Freeman, Tien Nguyen, Cyrus Bacchi, Nigel Yarlett, Robert Don, Robert Jacobs, Bakela Nare

PLOS Neglected Tropical Diseases: published February 8, 2011 | https://doi.org/10.1371/journal.pntd.0000956

Population Vulnerability and Disability in Kenya's Tsetse Fly Habitats

Sue C. Grady, Joseph P. Messina, Paul F. McCord

PLOS Neglected Tropical Diseases: published February 8, 2011 | https://doi.org/10.1371/journal.pntd.0000957

Spatial Modelling of Soil-Transmitted Helminth Infections in Kenya: A Disease Control Planning Tool

Rachel L. Pullan, Peter W. Gething, Jennifer L. Smith, Charles S. Mwandawiro, Hugh J. W. Sturrock, Caroline W. Gitonga, Simon I. Hay, Simon Brooker

PLOS Neglected Tropical Diseases: published February 8, 2011 | https://doi.org/10.1371/journal.pntd.0000958

Levofloxacin Cures Experimental Pneumonic Plague in African Green Monkeys

Robert Colby Layton, William Mega, Jacob D. McDonald, Trevor L. Brasel, Edward B. Barr, Andrew P. Gigliotti, Frederick Koster

PLOS Neglected Tropical Diseases: published February 8, 2011 | https://doi.org/10.1371/journal.pntd.0000959

Options for Active Case Detection of Visceral Leishmaniasis in Endemic Districts of India, Nepal and Bangladesh, Comparing Yield, Feasibility and Costs

Shri Prakash Singh, Siddhivinayak Hirve, M. Mamun Huda, Megha Raj Banjara, Narendra Kumar, Dinesh Mondal, Shyam Sundar, Pradeep Das, Chitra Kumar Gurung, Suman Rijal, C. P. Thakur, Beena Varghese, Axel Kroeger

PLOS Neglected Tropical Diseases: published February 8, 2011 | https://doi.org/10.1371/journal.pntd.0000960

A Portrait of the Transcriptome of the Neglected Trematode, Fasciola gigantica—Biological and Biotechnological Implications

Neil D. Young, Aaron R. Jex, Cinzia Cantacessi, Ross S. Hall, Bronwyn E. Campbell, Terence W. Spithill, Sirikachorn Tangkawattana, Prasarn Tangkawattana, Thewarach Laha, Robin B. Gasser

PLOS Neglected Tropical Diseases: published February 1, 2011 | https://doi.org/10.1371/journal.pntd.0001004

Cover

Members of the National Human African Trypanosomiasis Control Programme in Chad working in a village of the Bodo focus.