A young man suffering from sleeping sickness rests on a bed at the Dipumba THA center in the province of Kasai, DRC, between two doses of intravenous treatment. He started NECT treatment (co-administration of intravenous eflornithine with oral nifurtimox) which was recently introduced for late-stage disease. Although NECT is a major improvement over the highly toxic melarsoprol, it still needs 2 daily intravenous infusions over 7 days. An oral treatment, as the one proposed with fexinidazole in this issue (see Torreele et al., 10.1371/journal.pntd.0000923), is urgently needed to support control programs and all efforts to eliminate sleeping sickness. DRC has the highest number of sleeping sickness cases in Africa.
Image Credit: Benoît Marquet
Viewpoints
Neurocysticercosis May No Longer Be a Public Health Problem in Mexico
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000831
Photo Quiz
A Case and Review of Noma
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Symposium
Pitfalls in the Diagnosis of Trypanosomiasis in Low Endemic Countries: A Case Report
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000823
Review
The Unknown Risk of Vertical Transmission in Sleeping Sickness—A Literature Review
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000783
Research Articles
Parasitic Worms: Knowledge, Attitudes, and Practices in Western Côte d’Ivoire with Implications for Integrated Control
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000910
Miltefosine in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis in Brazil: A Randomized and Controlled Trial
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000912
Bayesian Geostatistical Analysis and Prediction of Rhodesian Human African Trypanosomiasis
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000914
Revisiting the Immune Trypanolysis Test to Optimise Epidemiological Surveillance and Control of Sleeping Sickness in West Africa
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000917
Analyses of an Expressed Sequence Tag Library from Taenia solium, Cysticerca
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000919
Quantifying the Spatial Dimension of Dengue Virus Epidemic Spread within a Tropical Urban Environment
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000920
Granulomatous Reactivation during the Course of a Leprosy Infection: Reaction or Relapse
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000921
The Extinction of Dengue through Natural Vulnerability of Its Vectors
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000922
Fexinidazole – A New Oral Nitroimidazole Drug Candidate Entering Clinical Development for the Treatment of Sleeping Sickness
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000923
Subversion of Innate Defenses by the Interplay between DENV and Pre-Existing Enhancing Antibodies: TLRs Signaling Collapse
PLOS Neglected Tropical Diseases: published December 21, 2010 | https://doi.org/10.1371/journal.pntd.0000924
Ecology and Transmission of Buruli Ulcer Disease: A Systematic Review
PLOS Neglected Tropical Diseases: published December 14, 2010 | https://doi.org/10.1371/journal.pntd.0000911
Sex, Subdivision, and Domestic Dispersal of Trypanosoma cruzi Lineage I in Southern Ecuador
PLOS Neglected Tropical Diseases: published December 14, 2010 | https://doi.org/10.1371/journal.pntd.0000915
The Potential Economic Value of a Trypanosoma cruzi (Chagas Disease) Vaccine in Latin America
PLOS Neglected Tropical Diseases: published December 14, 2010 | https://doi.org/10.1371/journal.pntd.0000916
Responses of Human Endothelial Cells to Pathogenic and Non-Pathogenic Leptospira Species
PLOS Neglected Tropical Diseases: published December 14, 2010 | https://doi.org/10.1371/journal.pntd.0000918
Fusion between Leishmania amazonensis and Leishmania major Parasitophorous Vacuoles: Live Imaging of Coinfected Macrophages
PLOS Neglected Tropical Diseases: published December 7, 2010 | https://doi.org/10.1371/journal.pntd.0000905
Focus–Specific Clinical Profiles in Human African Trypanosomiasis Caused by Trypanosoma brucei rhodesiense
PLOS Neglected Tropical Diseases: published December 7, 2010 | https://doi.org/10.1371/journal.pntd.0000906
Analysis of Salmonella enterica Serotype Paratyphi A Gene Expression in the Blood of Bacteremic Patients in Bangladesh
PLOS Neglected Tropical Diseases: published December 7, 2010 | https://doi.org/10.1371/journal.pntd.0000908
Contrasting Spatial Distribution and Risk Factors for Past Infection with Scrub Typhus and Murine Typhus in Vientiane City, Lao PDR
PLOS Neglected Tropical Diseases: published December 7, 2010 | https://doi.org/10.1371/journal.pntd.0000909
A Novel Tropically Stable Oral Amphotericin B Formulation (iCo-010) Exhibits Efficacy against Visceral Leishmaniasis in a Murine Model
PLOS Neglected Tropical Diseases: published December 7, 2010 | https://doi.org/10.1371/journal.pntd.0000913