August 2009

Confocal fluorescence micrograph of two in vitro-derived primary sporocysts of Schistosoma mansoni showing the somatic distribution of immunoreactive elongation factor 1a (EF1a) protein (green). Larvae are counterstained for actin (red) and DNA (blue) using Alexa-phalloidin and Hoechst dye, respectively. EF1a was one of 32 genes selected for larval phenotypic profiling by RNA interference (see article by de Moraes Mourão, et al. doi:10.1371/journal.pntd.0000502).

Image Credit: M. de Moraes Mourão, N. Dinguirard. Image was captured using a Nikon Eclipse TE2000 epifluorescent microscope equipped with a Bio-Rad Radiance 2100 MP Rainbow confocal imaging system (Keck Laboratory for Biological Imaging, University of Wisconsin).

Editorial

A Constitutional Amendment for Deworming

Peter J. Hotez

PLOS Neglected Tropical Diseases: published August 25, 2009 | https://doi.org/10.1371/journal.pntd.0000454

Viewpoints

Assessing the Impact of a Missed Mass Drug Administration in Haiti

Kimberly Y. Won, Madsen Beau de Rochars, Dominique Kyelem, Thomas G. Streit, Patrick J. Lammie

PLOS Neglected Tropical Diseases: published August 25, 2009 | https://doi.org/10.1371/journal.pntd.0000443

Reviews

Neglected Tropical Diseases in Sub-Saharan Africa: Review of Their Prevalence, Distribution, and Disease Burden

Peter J. Hotez, Aruna Kamath

PLOS Neglected Tropical Diseases: published August 25, 2009 | https://doi.org/10.1371/journal.pntd.0000412

Advancing Drug Innovation for Neglected Diseases—Criteria for Lead Progression

Solomon Nwaka, Bernadette Ramirez, Reto Brun, Louis Maes, Frank Douglas, Robert Ridley

PLOS Neglected Tropical Diseases: published August 25, 2009 | https://doi.org/10.1371/journal.pntd.0000440

Research Articles

A Schistosome cAMP-Dependent Protein Kinase Catalytic Subunit Is Essential for Parasite Viability

Brett E. Swierczewski, Stephen J. Davies

PLOS Neglected Tropical Diseases: published August 25, 2009 | https://doi.org/10.1371/journal.pntd.0000505

Adenosine Kinase of T. b. rhodesiense Identified as the Putative Target of 4-[5-(4-phenoxyphenyl)-2H-pyrazol-3-yl]morpholine Using Chemical Proteomics

Sabine Kuettel, Marc Mosimann, Pascal Mäser, Marcel Kaiser, Reto Brun, Leonardo Scapozza, Remo Perozzo

PLOS Neglected Tropical Diseases: published August 25, 2009 | https://doi.org/10.1371/journal.pntd.0000506

Importance of Coverage and Endemicity on the Return of Infectious Trachoma after a Single Mass Antibiotic Distribution

Takele Lakew, Wondu Alemayehu, Muluken Melese, Elizabeth Yi, Jenafir I. House, Kevin C. Hong, Zhaoxia Zhou, Kathryn J. Ray, Travis C. Porco, Bruce D. Gaynor, Thomas M. Lietman, Jeremy D. Keenan

PLOS Neglected Tropical Diseases: published August 25, 2009 | https://doi.org/10.1371/journal.pntd.0000507

Co-authorship Network Analysis: A Powerful Tool for Strategic Planning of Research, Development and Capacity Building Programs on Neglected Diseases

Carlos Medicis Morel, Suzanne Jacob Serruya, Gerson Oliveira Penna, Reinaldo Guimarães

PLOS Neglected Tropical Diseases: published August 18, 2009 | https://doi.org/10.1371/journal.pntd.0000501

Cooperative Blood-feeding and the Function and Implications of Feeding Aggregations in the Sand Fly, Lutzomyia longipalpis (Diptera: Psychodidae)

Frédéric Tripet, Simon Clegg, Dia-Eldin Elnaiem, Richard D. Ward

PLOS Neglected Tropical Diseases: published August 18, 2009 | https://doi.org/10.1371/journal.pntd.0000503

Reduced Susceptibility to Praziquantel among Naturally Occurring Kenyan Isolates of Schistosoma mansoni

Sandra D. Melman, Michelle L. Steinauer, Charles Cunningham, Laura S. Kubatko, Ibrahim N. Mwangi, Nirvana Barker Wynn, Martin W. Mutuku, Diana M. S. Karanja, Daniel G. Colley, Carla L. Black, William Evan Secor, Gerald M. Mkoji, Eric S. Loker

PLOS Neglected Tropical Diseases: published August 18, 2009 | https://doi.org/10.1371/journal.pntd.0000504

High-Resolution Sonography: A New Technique to Detect Nerve Damage in Leprosy

Suman Jain, Leo H. Visser, T. L. N. Praveen, P. Narasimha Rao, Thummalakunta Surekha, Ramesh Ellanti, Thummalakunta L. N. Abhishek, Indira Nath

PLOS Neglected Tropical Diseases: published August 11, 2009 | https://doi.org/10.1371/journal.pntd.0000498

The New Anthelmintic Tribendimidine is an L-type (Levamisole and Pyrantel) Nicotinic Acetylcholine Receptor Agonist

Yan Hu, Shu-Hua Xiao, Raffi V. Aroian

PLOS Neglected Tropical Diseases: published August 11, 2009 | https://doi.org/10.1371/journal.pntd.0000499

Predicting Neuropathy and Reactions in Leprosy at Diagnosis and Before Incident Events—Results from the INFIR Cohort Study

W. Cairns S. Smith, Peter G. Nicholls, Loretta Das, Pramila Barkataki, Sujai Suneetha, Lavanya Suneetha, Rupendra Jadhav, P. S. S. Sundar Rao, Einar P. Wilder-Smith, Diana N. J. Lockwood, Wim H. van Brakel

PLOS Neglected Tropical Diseases: published August 11, 2009 | https://doi.org/10.1371/journal.pntd.0000500

Cover

RNAi-altered gene expression in larval schistosomes.