Table of Contents: June 2009

Praziquantel is the major drug used to treat people infected with parasitic worms that cause schistosomiasis. However, the mechanism of action of praziquantel remains unclear. Nogi et al. (doi:10.1371/journal.pntd.0000464) identify a new biological activity of this drug to subvert regenerative polarity in a planarian to produce two-headed flatworms. By using this striking phenotype as a screen for molecules regulating in vivo praziquantel efficacy, the authors provide genetic evidence supporting the calcium channel hypothesis of praziquantel action.

Image Credit: Jonathan Marchant, University of Minnesota

Research Articles

The Neovolcanic Axis Is a Barrier to Gene Flow among Aedes aegypti Populations in Mexico That Differ in Vector Competence for Dengue 2 Virus

Saul Lozano-Fuentes, Ildefonso Fernandez-Salas, Maria de Lourdes Munoz, Julian Garcia-Rejon, Ken E. Olson, Barry J. Beaty, William C. Black IV

Tissue Specific Profiling of Females of Schistosoma japonicum by Integrated Laser Microdissection Microscopy and Microarray Analysis

Geoffrey N. Gobert, Donald P. McManus, Sujeevi Nawaratna, Luke Moertel, Jason Mulvenna, Malcolm K. Jones

Venezuelan Equine Encephalitis in Panama: Fatal Endemic Disease and Genetic Diversity of Etiologic Viral Strains

Evelia Quiroz, Patricia V. Aguilar, Julio Cisneros, Robert B. Tesh, Scott C. Weaver

Risk Factors for Helminth, Malaria, and HIV Infection in Pregnancy in Entebbe, Uganda

Patrick William Woodburn, Lawrence Muhangi, Stephen Hillier, Juliet Ndibazza, Proscovia Bazanya Namujju, Moses Kizza, Christine Ameke, Nicolas Emojong Omoding, Mark Booth, Alison Mary Elliott

Leptospira interrogans Stably Infects Zebrafish Embryos, Altering Phagocyte Behavior and Homing to Specific Tissues

J. Muse Davis, David A. Haake, Lalita Ramakrishnan

MIRO and IRbase: IT Tools for the Epidemiological Monitoring of Insecticide Resistance in Mosquito Disease Vectors

Emmanuel Dialynas, Pantelis Topalis, John Vontas, Christos Louis

Prevalence of Buruli Ulcer in Akonolinga Health District, Cameroon: Results of a Cross Sectional Survey

Klaudia Porten, Karen Sailor, Eric Comte, Adelaide Njikap, Agnes Sobry, Francois Sihom, Abanda Meva'a, Sarah Eyangoh, Mark Myatt, Fabienne Nackers, Rebecca F. Grais

High Burden of Impetigo and Scabies in a Tropical Country

Andrew C. Steer, Adam W. J. Jenney, Joseph Kado, Michael R. Batzloff, Sophie La Vincente, Lepani Waqatakirewa, E. Kim Mulholland, Jonathan R. Carapetis

When Can Antibiotic Treatments for Trachoma Be Discontinued? Graduating Communities in Three African Countries

Kathryn J. Ray, Thomas M. Lietman, Travis C. Porco, Jeremy D. Keenan, Robin L. Bailey, Anthony W. Solomon, Matthew J. Burton, Emma Harding-Esch, Martin J. Holland, David Mabey

A Combined CXCL10, CXCL8 and H-FABP Panel for the Staging of Human African Trypanosomiasis Patients

Alexandre Hainard, Natalia Tiberti, Xavier Robin, Veerle Lejon, Dieudonné Mumba Ngoyi, Enock Matovu, John Charles Enyaru, Catherine Fouda, Joseph Mathu Ndung'u, Frédérique Lisacek, Markus Müller, Natacha Turck, Jean-Charles Sanchez

Epilepsy in Onchocerciasis Endemic Areas: Systematic Review and Meta-analysis of Population-Based Surveys

Sébastien D. S. Pion, Christoph Kaiser, Fernand Boutros-Toni, Amandine Cournil, Melanie M. Taylor, Stefanie E. O. Meredith, Ansgar Stufe, Ione Bertocchi, Walter Kipp, Pierre-Marie Preux, Michel Boussinesq

The Development of an Age-Structured Model for Trachoma Transmission Dynamics, Pathogenesis and Control

Manoj Gambhir, Maria-Gloria Basáñez, Matthew J. Burton, Anthony W. Solomon, Robin L. Bailey, Martin J. Holland, Isobel M. Blake, Christl A. Donnelly, Ibrahim Jabr, David C. Mabey, Nicholas C. Grassly

Genetic Diversity of the Cestode Echinococcus multilocularis in Red Foxes at a Continental Scale in Europe

Jenny Knapp, Jean-Mathieu Bart, Patrick Giraudoux, Marie-Louise Glowatzki, Isabelle Breyer, Francis Raoul, Peter Deplazes, Georg Duscher, Karel Martinek, Pavol Dubinsky, Marie-Hélène Guislain, Florence Cliquet, Thomas Romig, Andrzej Malczewski, Bruno Gottstein, Renaud Piarroux

Regulatory T Cell Expansion in HTLV-1 and Strongyloidiasis Co-infection Is Associated with Reduced IL-5 Responses to Strongyloides stercoralis Antigen

Martin Montes, Cesar Sanchez, Kristien Verdonck, Jordan E. Lake, Elsa Gonzalez, Giovanni Lopez, Angelica Terashima, Thomas Nolan, Dorothy E. Lewis, Eduardo Gotuzzo, A. Clinton White Jr

Evaluation of Wuchereria bancrofti GST as a Vaccine Candidate for Lymphatic Filariasis

Anandharaman Veerapathran, Gajalakshmi Dakshinamoorthy, Munirathinam Gnanasekar, Maryada Venkata Rami Reddy, Ramaswamy Kalyanasundaram

Inhibition of Lassa Virus Glycoprotein Cleavage and Multicycle Replication by Site 1 Protease-Adapted α1-Antitrypsin Variants

Anna Maisa, Ute Ströher, Hans-Dieter Klenk, Wolfgang Garten, Thomas Strecker

SmCL3, a Gastrodermal Cysteine Protease of the Human Blood Fluke Schistosoma mansoni

Jan Dvořák, Susan T. Mashiyama, Mohammed Sajid, Simon Braschi, Melaine Delcroix, Eric L. Schneider, Wilson H. McKerrow, Mahmoud Bahgat, Elizabeth Hansell, Patricia C. Babbitt, Charles S. Craik, James H. McKerrow, Conor R. Caffrey

T. cruzi OligoC-TesT: A Simplified and Standardized Polymerase Chain Reaction Format for Diagnosis of Chagas Disease

Stijn Deborggraeve, Ximena Coronado, Aldo Solari, Ines Zulantay, Werner Apt, Pascal Mertens, Thierry Laurent, Thierry Leclipteux, Tim Stessens, Jean-Claude Dujardin, Piet Herdewijn, Philippe Büscher

Soluble ST2 Levels Are Associated with Bleeding in Patients with Severe Leptospirosis

Jiri F. P. Wagenaar, M. Hussein Gasem, Marga G. A. Goris, Mariska Leeflang, Rudy A. Hartskeerl, Tom van der Poll, Cornelis van 't Veer, Eric C. M. van Gorp