Table of Contents

December 2008

This photo from the Usino study area in Papua New Guinea shows people carrying produce to a local market several kilometers from their homes and gardens. The track crosses several streams, and it is quite steep in some areas and slippery after rains. Subsistence farmers cannot afford to carry the extra burdens of acute filarial fevers or chronic lymphedema (see Weil et al., doi:10.1371/journal.pntd.0000344).

Image Credit: Gary J. Weil, Washington University School of Medicine


The Burden of Human African Trypanosomiasis

Eric M. Fèvre, Beatrix v. Wissmann, Susan C. Welburn, Pascal Lutumba

The Natural Progression of Gambiense Sleeping Sickness: What Is the Evidence?

Francesco Checchi, João A. N. Filipe, Michael P. Barrett, Daniel Chandramohan

Research Articles

The Natural History of Trachoma Infection and Disease in a Gambian Cohort with Frequent Follow-Up

Nicholas C. Grassly, Michael E. Ward, Shirley Ferris, David C. Mabey, Robin L. Bailey

Immunogenicity of Fractional Doses of Tetravalent A/C/Y/W135 Meningococcal Polysaccharide Vaccine: Results from a Randomized Non-Inferiority Controlled Trial in Uganda

Philippe J. Guerin, Lisbeth M. Næss, Carole Fogg, Einar Rosenqvist, Loretxu Pinoges, Francis Bajunirwe, Carolyn Nabasumba, Ray Borrow, Leif O. Frøholm, Salah Ghabri, Vincent Batwala, Rogers Twesigye, Ingeborg S. Aaberge, John-Arne Røttingen, Patrice Piola, Dominique A. Caugant

The Impact of Repeated Rounds of Mass Drug Administration with Diethylcarbamazine Plus Albendazole on Bancroftian Filariasis in Papua New Guinea

Gary J. Weil, Will Kastens, Melinda Susapu, Sandra J. Laney, Steven A. Williams, Christopher L. King, James W. Kazura, Moses J. Bockarie

Patterns in Age-Seroprevalence Consistent with Acquired Immunity against Trypanosoma brucei in Serengeti Lions

Sue Welburn, Kim Picozzi, Paul G. Coleman, Craig Packer

Leishmanicidal Metabolites from Cochliobolus sp., an Endophytic Fungus Isolated from Piptadenia adiantoides (Fabaceae)

Fernanda Fraga Campos, Luiz Henrique Rosa, Betania Barros Cota, Rachel Basques Caligiorne, Ana Lúcia Teles Rabello, Tânia Maria Almeida Alves, Carlos Augusto Rosa, Carlos Leomar Zani

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