Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease

• Jennifer Riley,

  Affiliation Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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• Stephen Brand,

  Affiliation Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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• Michael Voice,

  Affiliation CYPEX, Dundee, United Kingdom

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• Ivan Caballero,

  Affiliation Molecular Discovery Research-Tres Cantos, GlaxoSmithKline, Centro de Investigación Básica, Tres Cantos, Spain

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• David Calvo,

  Affiliation Molecular Discovery Research-Tres Cantos, GlaxoSmithKline, Centro de Investigación Básica, Tres Cantos, Spain

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• Kevin D. Read

  * E-mail: k.read@dundee.ac.uk

  Affiliation Drug Discovery Unit, Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Dundee, United Kingdom

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