#NEXUS begin taxa; dimensions ntax=37; taxlabels As-CYP-2C39[&Text="GenBank: ADY43810",Created=Sat Mar 05 00:00:00 EST 2011,Modified=Wed Apr 25 16:12:14 EDT 2012,description="Cytochrome P450 2C39 [Ascaris suum]","Genetic Code"="Standard",Topology="linear","Common Name"="pig roundworm",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea; Ascarididae; Ascaris",Accession="ADY43810",Organism="Ascaris suum","Molecule Type"="AA",GID="324509042"] Ce-CYP-14A1[&Text="NCBI: NP_510203",Created=Mon Dec 03 00:00:00 EST 2001,Modified=Wed May 23 17:13:32 EDT 2012,description="CYtochrome P450 family member (cyp-14A1) [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="NP_510203",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="17568775"] Ss-CYP-1[&Created=Wed Mar 14 12:22:08 EDT 2012,Modified=Wed May 23 16:57:56 EDT 2012,description="contig-86204",Topology="linear"] Ss-CYP-3[&Created=Wed Mar 14 12:22:26 EDT 2012,Modified=Wed May 23 16:58:12 EDT 2012,description="contig-90255",Topology="linear"] Ss-CYP-4[&Created=Wed Mar 14 12:22:33 EDT 2012,Modified=Wed May 23 16:58:19 EDT 2012,description="contig-99394",Topology="linear"] Bm-CYP-C[&Text="NCBI: XP_001900320",Created=Thu Mar 20 00:00:00 EDT 2008,Modified=Wed Apr 25 16:11:20 EDT 2012,description="Cytochrome P450 family protein [Brugia malayi]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea; Onchocercidae; Brugia",Accession="XP_001900320",Organism="Brugia malayi","Molecule Type"="AA",GID="170591122"] Ll-CYP-A[&Text="NCBI: XP_003139614",Created=Mon Nov 15 00:00:00 EST 2010,Modified=Wed Apr 25 16:10:21 EDT 2012,description="cytochrome P450 family protein [Loa loa]","Genetic Code"="Standard",Topology="linear","Common Name"="eye worm",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea; Onchocercidae; Loa",Accession="XP_003139614",Organism="Loa loa","Molecule Type"="AA",GID="312073647"] Ss-CYP-5[&Created=Wed May 23 16:56:03 EDT 2012,Modified=Wed May 23 16:57:14 EDT 2012,description="contig-55075 ByteAddress=16170783, GeneiousOriginalName='contig-55075'",Topology="linear"] Ce-CYP-23A1[&Text="NCBI: NP_494797",Created=Mon Dec 03 00:00:00 EST 2001,Modified=Wed Apr 25 15:48:12 EDT 2012,description="CYtochrome P450 family member (cyp-23A1) [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="NP_494797",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="17531287"] Ce-CYP-33C1[&Text="NCBI: NP_503592",Created=Mon Dec 03 00:00:00 EST 2001,Modified=Wed Apr 25 16:47:28 EDT 2012,description="CYtochrome P450 family member (cyp-33C1) [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="NP_503592",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="17558634"] Ce-CYP-33D1[&Text="NCBI: NP_507076",Created=Mon Dec 03 00:00:00 EST 2001,Modified=Wed Apr 25 16:47:37 EDT 2012,description="CYtochrome P450 family member (cyp-33D1) [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="NP_507076",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="17562204"] Ss-CYP-2[&Created=Wed Mar 14 12:22:17 EDT 2012,Modified=Wed May 23 16:58:05 EDT 2012,description="contig-87602",Topology="linear"] Bm-CYP-D[&Text="NCBI: XP_001899881",Created=Thu Mar 20 00:00:00 EDT 2008,Modified=Wed Apr 25 16:11:27 EDT 2012,description="cytochrome P450 [Brugia malayi]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea; Onchocercidae; Brugia",Accession="XP_001899881",Organism="Brugia malayi","Molecule Type"="AA",GID="170590242"] Ll-CYP-B[&Text="NCBI: XP_003138701",Created=Mon Nov 15 00:00:00 EST 2010,Modified=Wed Apr 25 16:10:31 EDT 2012,description="cytochrome P450 [Loa loa]","Genetic Code"="Standard",Topology="linear","Common Name"="eye worm",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea; Onchocercidae; Loa",Accession="XP_003138701",Organism="Loa loa","Molecule Type"="AA",GID="312071639"] Ss-CYP-9[&Created=Wed Mar 14 12:26:53 EDT 2012,Modified=Wed May 23 16:57:48 EDT 2012,description="contig-205002",Topology="linear"] Bx-DAF-9[&Text="GenBank: ADB22437",Created=Mon Jan 11 00:00:00 EST 2010,Modified=Wed Apr 25 16:24:16 EDT 2012,description="DAF-9 [Bursaphelenchus xylophilus]","Genetic Code"="Standard",Topology="linear","Common Name"="pine wood nematode",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Tylenchida; Aphelenchoidoidea; Aphelenchoididae; Bursaphelenchus",Accession="ADB22437",Organism="Bursaphelenchus xylophilus","Molecule Type"="AA",GID="343082193"] Cb-DAF-9[&Text="NCBI: XP_002644834",Created=Tue Nov 17 00:00:00 EST 2009,Modified=Wed Apr 25 16:47:58 EDT 2012,description="C. briggsae CBR-DAF-9 protein [Caenorhabditis briggsae]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="XP_002644834",Organism="Caenorhabditis briggsae","Molecule Type"="AA",GID="268579703"] Ce-DAF-9[&Text="NCBI: NP_741807",Created=Thu Nov 21 00:00:00 EST 2002,Modified=Wed Apr 25 15:48:19 EDT 2012,description="abnormal DAuer Formation family member (daf-9) [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="NP_741807",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="71996277"] As-CYP-13A3[&Text="GenBank: ADY45109",Created=Sat Mar 05 00:00:00 EST 2011,Modified=Wed Apr 25 16:12:36 EDT 2012,description="Cytochrome P450 CYP13A3 [Ascaris suum]","Genetic Code"="Standard",Topology="linear","Common Name"="pig roundworm",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea; Ascarididae; Ascaris",Accession="ADY45109",Organism="Ascaris suum","Molecule Type"="AA",GID="324512327"] As-CYP-3A24[&Text="GenBank: ADY43509",Created=Sat Mar 05 00:00:00 EST 2011,Modified=Wed Apr 25 17:19:15 EDT 2012,description="Cytochrome P450 3A24 [Ascaris suum]","Genetic Code"="Standard",Topology="linear","Common Name"="pig roundworm",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea; Ascarididae; Ascaris",Accession="ADY43509",Organism="Ascaris suum","Molecule Type"="AA",GID="324508307"] As-CYP-3A31[&Text="GenBank: ADY43572",Created=Sat Mar 05 00:00:00 EST 2011,Modified=Wed Apr 25 16:11:59 EDT 2012,description="Cytochrome P450 3A31 [Ascaris suum]","Genetic Code"="Standard",Topology="linear","Common Name"="pig roundworm",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea; Ascarididae; Ascaris",Accession="ADY43572",Organism="Ascaris suum","Molecule Type"="AA",GID="324508465"] As-CYP-4C1[&Text="GenBank: ADY45110",Created=Sat Mar 05 00:00:00 EST 2011,Modified=Wed Apr 25 17:00:37 EDT 2012,description="Cytochrome P450 4C1 [Ascaris suum]","Genetic Code"="Standard",Topology="linear","Common Name"="pig roundworm",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Ascaridida; Ascaridoidea; Ascarididae; Ascaris",Accession="ADY45110",Organism="Ascaris suum","Molecule Type"="AA",GID="324512329"] Ce-CYP-29A4[&Text="GenBank: CAB11775",Created=Fri Sep 12 00:00:00 EDT 1997,Modified=Wed May 23 17:15:50 EDT 2012,description="Protein CYP-29A4 [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="CAB11775",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="198446543"] Ce-CYP-37B1[&Text="GenBank: CAB07604",Created=Thu Mar 27 00:00:00 EST 1997,Modified=Wed May 23 17:13:40 EDT 2012,description="Protein CYP-37B1 [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="CAB07604",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="3876517"] Ss-CYP-6[&Created=Wed May 23 16:56:09 EDT 2012,Modified=Wed May 23 16:57:23 EDT 2012,description="contig-38001 ByteAddress=7748717, GeneiousOriginalName='contig-38001'",Topology="linear"] Ss-CYP-7[&Created=Wed May 23 16:56:14 EDT 2012,Modified=Wed May 23 16:57:32 EDT 2012,description="contig-90305 ByteAddress=9773036, GeneiousOriginalName='contig-90305'",Topology="linear"] Ss-CYP-10[&Created=Wed May 23 16:56:38 EDT 2012,Modified=Wed May 23 16:57:05 EDT 2012,description="contig-138349 ByteAddress=6315022, GeneiousOriginalName='contig-138349'",Topology="linear"] Bm-CYP-A[&Text="NCBI: XP_001901707",Created=Thu Mar 20 00:00:00 EDT 2008,Modified=Wed Apr 25 16:11:02 EDT 2012,description="Cytochrome P450 family protein [Brugia malayi]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea; Onchocercidae; Brugia",Accession="XP_001901707",Organism="Brugia malayi","Molecule Type"="AA",GID="170593911"] Bm-CYP-B[&Text="NCBI: XP_001901706",Created=Thu Mar 20 00:00:00 EDT 2008,Modified=Wed Apr 25 16:11:10 EDT 2012,description="Cytochrome P450 family protein [Brugia malayi]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Spirurida; Filarioidea; Onchocercidae; Brugia",Accession="XP_001901706",Organism="Brugia malayi","Molecule Type"="AA",GID="170593909"] Ss-CYP-8[&Created=Wed May 23 16:56:28 EDT 2012,Modified=Wed May 23 16:57:41 EDT 2012,description="contig-57183 ByteAddress=17282693, GeneiousOriginalName='contig-57183'",Topology="linear"] Ts-CYP-4V2[&Text="NCBI: XP_003370228",Created=Fri Jul 01 00:00:00 EDT 2011,Modified=Wed Apr 25 17:01:21 EDT 2012,description="cytochrome P450 4V2 [Trichinella spiralis]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Enoplea; Trichocephalida; Trichinellidae; Trichinella",Accession="XP_003370228",Organism="Trichinella spiralis","Molecule Type"="AA",GID="339256704"] Ce-CYP-36A1[&Text="NCBI: NP_492267",Created=Mon Dec 03 00:00:00 EST 2001,Modified=Wed Apr 25 16:47:17 EDT 2012,description="CYtochrome P450 family member (cyp-36A1) [Caenorhabditis elegans]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Chromadorea; Rhabditida; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis",Accession="NP_492267",Organism="Caenorhabditis elegans","Molecule Type"="AA",GID="17505847"] Dm-CYP-18A1[&Text="GenBank: AAN09473",Created=Fri Sep 13 00:00:00 EDT 2002,Modified=Wed Apr 25 15:48:51 EDT 2012,description="cytochrome P450-18a1, isoform A [Drosophila melanogaster]","Genetic Code"="Standard",Topology="linear","Common Name"="fruit fly",Taxonomy="Eukaryota; Metazoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora",Accession="AAN09473",Organism="Drosophila melanogaster","Molecule Type"="AA",GID="22832514"] Hs-CYP17A[&Text="GenBank: P05093",Created=Thu Aug 13 00:00:00 EDT 1987,Modified=Wed Apr 25 16:34:28 EDT 2012,description="RecName: Full=Steroid 17-alpha-hydroxylase/17,20 lyase; AltName: Full=CYPXVII; AltName: Full=Cytochrome P450 17A1; AltName: Full=Cytochrome P450-C17; Short=Cytochrome P450c17; AltName: Full=Steroid 17-alpha-monooxygenase","Genetic Code"="Standard",Topology="linear","Common Name"="human",Taxonomy="Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo",Accession="P05093",Organism="Homo sapiens","Molecule Type"="AA",GID="117283"] Hs-CYP21B[&Text="GenBank: AAA52063",Created=Tue Apr 27 00:00:00 EDT 1993,Modified=Wed Apr 25 15:39:33 EDT 2012,description="CYP21B protein [Homo sapiens]","Genetic Code"="Standard",Topology="linear","Common Name"="human",Taxonomy="Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo",Accession="AAA52063",Organism="Homo sapiens","Molecule Type"="AA",GID="180962"] Ts-TAS-A[&Text="NCBI: XP_003380197",Created=Fri Jul 01 00:00:00 EDT 2011,Modified=Wed Apr 25 17:01:53 EDT 2012,description="putative thromboxane-A synthase [Trichinella spiralis]","Genetic Code"="Standard",Topology="linear",Taxonomy="Eukaryota; Metazoa; Nematoda; Enoplea; Trichocephalida; Trichinellidae; Trichinella",Accession="XP_003380197",Organism="Trichinella spiralis","Molecule Type"="AA",GID="339237285"] Hs_CYP27A1[&Text="GenBank: AAH40430",Created=Tue Nov 02 00:00:00 EST 2004,Modified=Wed May 23 17:11:36 EDT 2012,description="Cytochrome P450, family 27, subfamily A, polypeptide 1 [Homo sapiens]","Genetic Code"="Standard",Topology="linear","Common Name"="human",Taxonomy="Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo",Accession="AAH40430",Organism="Homo sapiens","Molecule Type"="AA",GID="55249608"] ; end; begin characters; dimensions nchar=679; format datatype=protein missing=? gap=-; matrix As-CYP-2C39 --------------------------------------------------------MILPALAIL-------------------------SLLILYILSYYKNVSRYPKGPVPLPLIGNLHQIE-------MYKTHLYLERLSKVYGPVFTIFLP-KPTVVITRFDAIKEALLKKGSDFAGR-PDGYPDVVFQGT--ENGGIIFSQGENWMEQRRTSLHILRDL-----GLGKNVVEQQVLRSVDEFLHQLEAETDK-----DHIDFRWPIQFCVANVITEILFGYHHD-HNDCEEFKRIAEIVRSV-----------------VGDVRSHKMIYFAQQFP----IIAKIPIVNRFGVRRITTEAEKVKQYVRSEVDKHIREYD-----ANSQAETFIHAYLSEMAKVGR-------RLSYEQLVDIATDFFLAGMETTTTTLRWGVLLMVAYNDVQEKMREEIFSIVGR---EREVRMVDKPNMPYCSAVIMEVQRIANILPFNVLHRTLRETTIAN-KQIPNDTLVLAQISTILSSSPVF-EEPNIFQPMRFLHEDGKTFRKDTM-EHFIPFGIGKRQCAGEPLARVELFLIFTNLLRKYRLEVPPDGYLPNLDPIPA-ALAFPRNYNVKIVPL------------------------------------------- Ce-CYP-14A1 --------------------------------------------------------MSVFILAFV-------------------------IFIIFYVFHFYWKVSKYPKGPLPLPFIGNIHQFP-------PDNVQKYFDVLSKTYGPCFTIWIP-FPAIVLTDYEHIKDAFVNQGDTFTYR-AHRSPETLLPVH--DHTGILASDGDHWRLQRRTSLKILRDF-----GLGRNLMEEQVIRSVHEMLIQLENINDK-----KNVDVFWPIQLCVGNVINETLFGFHYK-YEDSEKFKTFVKIVDKH-----------------LRHLQG-KMPLLVSAFP----WLKHVPIVGDIGYHNIKNNISSYHTFIEEEVATQVKKYD-----GESEPENFVHAYMQQMKQTGNP------GLDITNLCATVLDFWLAGMETTSNSLRWHLAFMMKYPEVQDKVRKEILDNVGT---ARLPSMSDKPNMPYTQAVIHEVQRCSNMIPFLGSHQCKEETEIHG-NRVPAGSLVFAQLWSVMRNDTVF-EDPETFNPSRYLQSDGKTFDKAVL-EKTIPFSIGKRNCVGEGLARMELFLIFSALIQKYEFVATSN---IDLTPDWG-VVLTAKPYTCNIIPQF------------------------------------------ Ss-CYP-1 -------------------------------------MLSNLNHFIQYLVPFKITTSIFLITIIS-------------------------MLIIIWVIKFYVKVYKYPKGPFPLPFIGNLLQLLP------FDAMPDKFEYYKKIYGPIFTIFIP-YPVVVLCDYESFKEALVKNSSILNGR-QKGYPESFVHPE--TGRGLVFADGPYWKEQRKVCFQIFRNF-----GVGRSLMESKIMDYVNETLNYVEKKRKD-----GPIDFTWIYKACFANIMCELLFGIKRS-LEDDQEIKFIMEPLEKV-----------------FELGRS-GISLIYHFFNNNPWIIKILKKINNIGRAELEIAFKHMNSIIIEAKSTWVKGK---------EPKNFVHAYMEKTNSDDE-------YINEVEMPFVVHDVWVAGMETTATTLNWAMNILGTFTEKQEKFRKEIHDVIGY---DTTIHYDDRERLPYCQAVVYEILRFSNILPHNITHRTEKDVIIGG-KLIPNDTIVFAQQYNIMKYDPIF-YESNKFIPERFLMEDEKTYRKEAV-DRMLAFSAGSRKCIGENMALMQIFLFLTNLLSRYEIKAPKGGPMPSLSGKWA-GIIKAPSFAFDVVKVRTK---------------------------------------- Ss-CYP-3 ----------------------------------------------------------MIGILIV-------------------------LFVVIYLINFYKKIKSLPPGPMPLPIIGNLYSIN-------LKKMHLWIYEQKKIYGNVFTVWLP-SPQVVFADYDSIYESQHKNADNFAGRNVGGFPDKCIHDK--DNVGIVLSEGEEWRDQRRLSLQILRNF-----GMSKTIMQDKIHLVIQDSWDHLDNLKDK-----DNVDICKVIQLAVGNIINSLLFNYIYT-YDDSESFFEFVSTLENV-----------------LKQNKTWEFQLIMLIP-----AVDKIPIIKDLLYKRITKHQEKLRYLTDIEIEKCKKTYN-----ADEEPTNFIHAVMKEIQSIDSKY----SYLNSDHLRGLTLDFWMAGLETSSTTLKWFTLLIMKHLDIQERLQKEIDEVIGK---ENLVQLSDKAKMPYMSAFISEGQRYINMVPLVPSHKCTKDTIING-HLITNGTLTQPFFWGANRDEKYF-KDSFNFNPKRFLDEEEKVYK--VE-NDHMAFGKGKRICAGKSLADAEIFLFFTSFLQRYKFTHPNGP--VDLSTEFG-GVLLPKPFTCKIERR------------------------------------------- Ss-CYP-4 ----------------------------------------------------------MIGIFLI-------------------------FIISIYLINFYKKIKSLPPGPVPLPVIGNLLSVD-------IKKIHLYAMEQSKKYGDVFTLWLP-HPIVVISGYDTIKEAVIKNGDNFNGRNVYGYPENTIHEI--VNVGVVFSEGEEWRDQRRLSLQILRNF-----GMSKTIIQDKIHISISDAINYIDNLQDK-----DNVDIGRVIYLSIGNVISLILFGSMYK-HDNSEEFFNFINNLDDS-----------------IKKRASVESKILLMFP-----IIQKIPFLKEFIYKRIAKPTRKLKELTNQQIELIKKDFD-----PNNDPPNFIHAVMKEIQAIDSKY----SYLNSDHLNGMVLDFWTAGTETTSTTIKWLLLFAMKYLDIQEKLHNEIDEVIGR---DHLVLLSDKNRMPYMSAFIAEGQRFANIVPFVPFHKCTIDTVING-RLIPKDTLTQPFFWSANVDEKYF-KDPYTFNPNRFLSDDGKKFN--PK-HDHLSFGLGKRSCVGKSLAEAELFLMFTSLLQKYKFTHINGP--VDLSYDFG-DVSLVRPYKCKIEKR------------------------------------------- Bm-CYP-C -------------------------------MYSFRFILLFVMMIIAISS----ILYSKTWISFIPLPIPP---------------TLMLLAAVYIFHELSWKRRFLPPGPTPWLFFGNILHFIF------YESIDDMFLTWKQKYGNLVTFWIGPIPLVMVTDVETMREYFVRNSEIFC---------FDVGG----ANGIIQIDGDKWKQQRRFVLRVLRDF-----GVGRILIEQQIMNEVESFIDYLEAKCT--G---QEMDICAMHAVCVGNIINNILFGYRFP--QGSAEFSFLHSLLDSQ-----------------SRLVMHPLMGLYITLP------LTTRIPFINYKWKQFKDLRNKLWKFISREVQVHMKAFN---CEESPEIIDFTYAYLSEINRRKR-SGEPSEYFSEWQLTMLLLDLFYAGMETTVTTLKWGFLLSMIHPDVQTKVQNELDEIGS------RITLADKSKCSYTMATIHEIQRFANILPINLLRTVAEDVVMGK-YYYPAGTLCIPQISIAMNDPTNF-EKPREFRPERFLEDDGFTLKK--Y-DAFFPFSIGKRQCLGESLAKAELFLIYANLIRHFRFRTVPNRPNPSTKRLFG-LTTSPPPYKCVVEKRIV----------------------------------------- Ll-CYP-A --------------MIRLITTFRRRSDFNSTMYSFQFVLLYGIVIIAICS----VLLSKTWISFVPLPIPP---------------SLALLAAIYIFYDLSWKRRFLPPGPAPWLFFGNILHFMF------YKSIDDMFLTWKRKYGNLVTFWIGPIPLVMVTDVETMHEYFVRNAEIFSNRWRNYATDFFMGG----ANGIIQIDGNKWKQQRRFVLRVLRDF-----GVGRILIEQQIMKEVEFFIDYLEPKCT--G---QEMDICAMHAVCVGNIINNILFGYRFP--QGSVEFSFLHSLLDSQ-----------------SRLVMHPLMGLYITLP------LTTRIPFVNYKWKQFKGLRDKLWKFLSREVQIHMKAFN---CEESPEITDFTYAYLSEMNRRKK-VGEPNEYFSEWQLTMLLLDLFFAGMETTVTTLKWGFLLSVIHPEVQTKVQNELDDIGS------RITLADKPKCSYTMATIHEIQRFANILPINLLRTVAEDFVMGK-YYYPAGTLCIPQISIAMNDPTNF-EKPKEFRPERFLEDDGFTLKK--Y-DAFFPFSIGKRQCLGESLAKAELFLIYANLMRHFRFRTVPNKPNPSTKRLFG-LTTSPPPYKCLVERRIV----------------------------------------- Ss-CYP-5 ----------------MTSLTFIHYKKTQFQIITLLLLFILIFCGLTFKA----IELLKYLNVKILFYIG--------------------VLSIYIYHELYWKRKNLPPGPVPWLVAGNMPQLLLS-----INNIDKKFLEWKNKYGGQYTLWIGPIPMVFVSDVEKMKLYFVKNGEHFSNRWINYITDTFMDG----FNGVLQIHGDKWREQRRFSLHILRDF-----GVGRAEIEKRVMFEVEKMIEVLDKDCG--S---IELDLHEYFAACVGNIIITILFGKRFD--HNDPSFIELRDLLERQ-----------------TQLVIQPIMGLYCILP------LSTKIPFINSKWKELMMMKEKLFDFIDKELEEHKKKFD---PSEEP--TDFTYAYLKEIHDRIS-TNSDIGYFSIKQLRSLLLDLFFAGMETTVTTLKWGFLYLLRHPEELEKVQRELSELPN------IIKMSNRNNLPYLQAMTNEIQRKANILTFNLLRTTSTDVYIDN-YIFKKGTMVLPMISIVMNDSKYF-ENPEQFDPSRFLDDKGN-QKK--L-DGFLPFSIGKRQCLGESLAKAELYLVLANLLRNFNIKPDPKNSNPSIKRLLG-ITCSPQKYKLLITKRN------------------------------------------ Ce-CYP-23A1 ---------------------------MPSLRNAILLTIATTFLYFRIMR----TLNFDNYMATYIYFLT--------------------CITLYAIYELNYKRRRLPNGPVPWLVAGNMPSFIN------VNNVDVLFQSWKQQYGGIFTVWIGPIPLVMVSDLPTIKKYFIQHADSFSNRWRNFVTDSIMEG----SNGIVQIDGNKWREQRRFALHTLRDF-----GVGKPLMEQMITLEVTSLMNHMEKSCGLDG---KELHLCPSIAVCVGNIINNMLFGLRFN--QDNSYMHRLHQLLDDQ-----------------SHTVMQPIMGAYIAFP------VTSKIPIINGEWNRLMGIKNELLEFLETQIEGHRMNWKDEMIEQEP--EDLTYAYMIEVEKRKR-NGEDVGFFDDQQLKMLLLDLFFAGMETTVTTLKWAFLLMAKNQKVQKNVQAELDSIGQP-----MIEIQHRTRLPYVQATINEIQRIANILPINLLRTVAEDIEIDG-YNFKKGDLIIPQISILMNDPEIF-ENPEEFNPSRFLDEDNN-VKK--I-DEFLPFSIGRRQCLGESLARAELYLVFANLIQNFNFEVAD---DVTTERVLG-LTVSPVEYSCKITRRGLDHNQNSVK--------------------------------- Ce-CYP-33C1 -------------------------------------------------------------MIIILLLT---------------------FLTIYFVYELYWKRRNFPPGPCPLPVFGNLLSIANP-----PPGYKA-FERWTKKYGDVYTFWIGNTPHIMINTWDKIKETFIRDADTYTNKVVLPMVTLSRGG----EYGIIDSNGAMWREHRRFALSTMRDF-----GLGKNLMQENILMEVQDVFARLDAKLG------SETDVPEVFDHAVANVVNQLLFGYRFMGPKENE-YQELKHIIDSP-----------------AEIFGKLHIFLAMNIPI-----FAKLLPESL-YEGPIKTFRDTTLAFFNKQIEAHRHRIDFEDLNSES--TDFVETFLKEQKRRESEANSKNLNFSNIQLLNVCIDLWFAGLNTTTNTITWAISYVLHHPEVQDKIHEELDKVIGS---DRLITTADKNDLPYFNASINESQRGINILPLNLQHATTRDTVIDG-FKIPKGTGVVAQISTVMNNEEVF-PDPYTFNPDRFIDENGK-LKK--V-DELAPFSVGKRSCPGEGLARMELFLFIANFLNRYKIHPSKEG-LPSMAKGSG-PVVAPRLFTAILTRRF------------------------------------------ Ce-CYP-33D1 -------------------------------------------------------------MLLLLISS---------------------LIFLFFAYHFSWKRRNYPPGPTPLPLVGNLLQLQK-------FGYDI-FHKWKKEFGPVFTFWLADRPFIFITSYEVMKETFVKDGDTFADKQLNQIDKKKLQR----NYGVLDTNGEMWREHRRFTLSQLRDL-----GLGKDLMQEKILLEIEEQFKDINSHLG------EEIDLPSVLDRGVGNVINLTLFNKRFETNQRDE-FTYLKSLIDGL-----------------RDVASEFRYFIQFLVPW-----SSKIIPGPT-LGDKTKGMKEELDVFFVKQVEEHRKEIDFDTV--ES--YDYVEAYLKEQKKRE--ADGDHETFCNKQLYAMCFDLWMAGLQTTTVTLTWGFSFYLHNADVQLKIREELDRVIGN---DRLITTADKNCLPYLTAFINETQRCANIIPFNLLHVATRDTVIEG-YPVKKGTGVIAQIGTVMSDEQIF-PDAHCFNPGRFIE-NGK-LKK--V-DEVIPFSIGKRQCLGEGLARMELFLFFANIFNRYDVQLDFSGNLPDLDKSKD-NFVTPRKFNAVLNKRYV----------------------------------------- Ss-CYP-2 -------------------------------------------------------------MFVITILF---------------------FTIIFLLNNFYWKRRNLPKGPTPLPLFGNMLDIVKN-----PPGYDA-FIKWKKEYGNIYTYWFGSQHVVAICDYDLMVSTFLKDGDNFSGRNTFHLMNEDFRGG--ENYGILVSDGWQWREQRRFTIHTFRNF-----GMGKNLMEERILNEIVFLFNDIEKLNNM-----NDVFLMRNIDFCVASIINSLLLGYRFDGGAENEEYIRLKTLMEKH-----------------TKLMSSGIVAALLSGPR-----FLKYLPIFKNVYKKIIYNKDQMFLFIEKQIEKN--LKTFDNFG-EP--SNYVEAYLKEMNKKIN----EDSSFSMNQLKNVIMDLRTAGTDTTSNTISWGIAYILHNPEVQIKIHEEFDNIINS---DRLITIKDKDSLKYMNAVVNETQRMANLIPQNVLHRTYKDTIVDG-IFIPGGTCIIPQISILLYDEKIF-PNPYKFNPNRWLDENKN-LKK--I-EQFIPFSLGKRQCLGESLAKMELFLIMANIFNRYKIDIPESKKLPSLHKQMS-FTVCPEPYNVSLKLRL------------------------------------------ Bm-CYP-D -------------------------------------------------MTAIFAIIIFIFHAFIYYVYS----------------------------EYIVLRHKYPPGPIPLPFFGNFLQID-------LAYPHRSMIKWKKKFGPMFTIWLP-GPVIVLADYKLLREALVNQGNIFAGRPMSFVYGIFSNHHP-DGDGIILSQNEKWNHQRRFALRVFRNF-----GVGKNMMEQKIRYYADTLIQHLKKEIAASGLKTAVIDLHLPITFCVGNIIHDLVLGKNYE--YGDKEFLRFKKLIDST-----------------LKDFVSIPMLLVDRYP-----IIRFLLP----TYYRYCKNGFALQRFFLKHIDEHEKAIITSTD-KDDEPNDFIDAYLKNMIKYT-----EQRVYNKITLALNSGDLWTGGMETTVTTLRWAIIYLIHNPVVQKLVHDEIDKNLGT---RM-VYWADRTNMHYTMAVICEVQRIINILPWHIPHATTSNTTLYG-YKIQKGTMIMPQIGAINFDENLY-PNPEAFQPSRFLNSEGTLRNS----EHLIPFGIGKRSCLGEALARTELFIILTTLLQNFEFTAAY-GKPPSLKRHPG-MVSVPQEYVCQIRTRNEMA--------------------------------------- Ll-CYP-B -------------------------------------------------MTVLFAVIIFVFHIFIYYLYS----------------------------EYIVLRHKYPPGPIPLPFVGNFLQID-------LAYPHRSMIKWKKKFGPVFTIWLP-GPIVVLADYKLLREALISQGNIFAGRPMSFVYGIFSDHHP-DGDGIILSQNEKWNQQRRFALRVFRNF-----GMGKNMMEQKIRYYADILIQHLKKQIASTGLKSAVTDLHLPITFCVGNIIHDLVLGKNYV--YGDQEFLRFKKLIDSI-----------------LKDFVSVPMLLVDRYP-----LVRFLLP----TYYRYCKNGFALQRFFLKHIDEHEKRIINSTN-KDDEPNDFIDAYLKNMIKYT-----KERQYNKITLALNSGDLWTGGMETTVTTLRWAIIYLIHNPDIQKLVHDEIDKNLGT---RT-VYWADRTTMHYTLAVIYEVQRIINVLPWHIPHATTSSTTLCG-YKIEKGTMIMPQIGAINFDENLY-SNPEAFQPSRFLSSEGTLLNF----EHLIPFGIGKRSCLGEALARTELFIILTNLLQNFEFSAVN-GKRPSLKRYPG-MVSVPQEYVCQIRTRNEAA--------------------------------------- Ss-CYP-9 ----------------------------------------------------MLLIILFIIFSLIYICYN----------------------------FYTNIK-KYPNGPKPLPIIGNTHSID-------MASPYKTVMKWKKIYGDIFTIWLP-RPTIVLASANVIKEALIKNKEVFSSRPNSYIYGIFTGHKP-HGDGIILADGDNWYTQRNFALRIFREF-----GVGSKRMEYKIMLHTHRMLVYIFKKMCGS--KKVVIDLHHIISFTVGNIIHDLVMGRYFE--FHDPEFMHFKELIDSI-----------------LKDFTSIQMLIVDCYP-----FMRFFLP----TYYRYKRNGFKLQKYFLDEIERHSSKIENSLE-K-MKPTNFIDAYLLEMYK-S-----EDEELSKLTLALNAGDLWTGGMETTVTTLRWAILYMILHPQVQRKCFQEISGVLKD---NIDVTSEDRIRLPYIRATIDEIQRMINVLPWGIPHRVECDIKING-KFIPRDTTLLIQTGAIHFDEDEF-HDPNTFLPERFLNDDGSYMAV----RNNMPFGIGKRQCLGEPLARMELLLIFVTLIKNFEFCEGP-QGPPDMTRCEG-MTTVPKPYKVLLKKRHNNIKYANNNQIQKQPFEEELEKMREYKRLIMEEESKRNFNNE Bx-DAF-9 -------------------------------------------------MLFFLAIAIAIGVSLFMIKRNKC--------------------ELDEGCNDKLVESEYPPGPPPFPLVGNFPQID-------LAQPHKTMNEWKERYGEVFTVYLP-KPVVVLAGARALHEALVQKGEHFTGRPTTYLYTLFTRHSP-DGDGIILCRGPRWQAQRRIALRAFRGF-----GMGKKEMEARIMHHARIMIKRTSAQIKKNN-NGLITDLHYALAYCFGNIIHDLVMGTRFE--HDDGDFFRFKRMLDHT-----------------LEGVASVEMLLVNSFP-----WMRHILP----RFRRYVSEGFALQNFFKNEIERHAKALK-----EGEIADNFIDFYLKAMKE-E-----KQPYLNEWSCAINSGDLWTGGLETVVTTIRWAIIYFIHYPAVQKKIQAELDTVVGR---RP-LTLADRQHTPYFHAAMDEIQRIVNVLPWHIPHTCDKEVSVCG-VLIPKDSIIMPQPGAVFFDPKIF-PDPYTLRPERFLDKTGNYKPH----PDLNAFGLGKRACPGEALARVELYLVLGSMLQDLEFRADPRLGMPSLERCTG-MTAVPNPTLYMVVQRFERLLFEE----------------------------------- Cb-DAF-9 MISTSQQVTALLKDVIGKFK--------------AQMQMSNSLYIQIRDWVAFVVSHHVIMAMYFVLSYSVIPYFVPSVFWEKCFIRFFIVHLFLVVFLHYQRVTKYPPGPPPMAILGNSPFIN-------VLSPEKTFLEYREIYGPVFTLHLS-QPTVILADYKSIEEALVANGQKTSGRSSAESFVLFTGDRQ-DGDGVILAMRQKWKNMRQEILRFMSKW-----YG--KPMDELVLHHTRSLESELVKMAESKC----LIDLREPISGAIANVIQQITIGRNYL--YQDTEFQAQLKDINAV-----------------VKEIMTAEVFFVNCYP-----FLRFLPEGILRKWTNYKRSGFRLQQWFRTILDEHHINRHQG---------DFMSHMVDLQES-------RPDEFNDLSIILTCGDMWTGGMETTTTTLRWGIIYLLNNPEVQTKCHNELVKVFGT---DE-PEMSKMNQTPYVRATLSEIQRLANVLPWAIPHKTFEECQVGE-HKIPVNTEVIPALGALLCDPTLF-ENPKEFKPERFLDKEGKYYVM----EEFRPFGMGPRVCLGERVARTELYLIFASLLQNFRFYLNRTDPIPVAERIIGGITAPPKPYSTRVEYHGQRIVY------------------------------------- Ce-DAF-9 MHLENRVLSSVLDYASKFYKRMSSLVFFSANSIQVQMNISQSSWIKCRDWMAFALSHHIIMGIYLLILRNFLPQVVPDFEWQHYFMRVFIVHIIYIIISYFIRITRYPPGPPPMAVFGNSPFVN-------ILTPEQTFLEYREIYGPIFTLHLS-QPTIILAEYKTIQEALVKNGQQTSGRSSAESFVLFTGDRL-NGDGVILAMRQKWKDMRHEISRFMNKW-----YG--APMDELVLHHTRCLEQELAKIAETKS----LIDLRDPLAGAIANVIQQITIGRNYM--YQDQEFQTQLRDINAV-----------------VKEIMTAEVFFVNCYP-----WLRYLPEGILRKWTNYKRSGFRLQQWFRTILEEHHVNRHQG---------DFMSHMIDLQES-------KQEQFRDLSIILTCGDMWTGGMETTVTTLRWGIIYLLNNPEVQAKCQMEILDVFGN---DI-PDMGKMNQTPYVRATLSEIQRLANVLPWAIPHKTIEECNIGG-YDIPVNTEIIPALGAVLFDPNVF-ESPKQFKPERFLDEEGKYRVM----EEFRPFGLGPRVCLGERIARTELYLIFASLLQNFRFYLNRGDPIPVAERVIGGITAPPKPYATRVEYLGNRLIN------------------------------------- As-CYP-13A3 --------------------------------------------------------------------------------------------------------------------------MKS-------ESTPFRFQELRRQYGKTYAVMQGAFPTVVTSDVDVIQDVCLKKFRFFHSRMTDPTSGDPDKSRE---VHVFAARGERWKRIRSLTSPAL----------SNQNLRRLFTTINDSAWRFVNGLLEDNNNS-TPIELHRRFQNLTYDVISRCCLGRAES-CQKNDPNLELLLKKFSPHQIFDRFSFVSFSWCLPEWSALLSFYSSLRSQIRRMLRLQPDPLQVYAQKLYAIAERREKS--DEHYDFLQFLKNVEDNEWEGWRTMNDVQTDMNT-VKIPKK--------MIREEVVAQMRFMSSAGFDTTANTLTYLTYLLASHPDKQE----KLREEMD---NAGEACFDTVQKMEYLHWAISETLRLFPHASLLQSRRCVEDCDVGA-YKFKRGTNIVFDTWSLHHDPEVWGKDADEFRPERFG--ERTAEQM----RSWMPFGAGPRQCIGMRFALLEAKITMFQLLRNFRILKVDGTNRLHLRLREMGTVWPDSARVILEAR-------------------------------------------- As-CYP-3A24 --------------------------------------------------------------------------------------------------------------------------MQR-------GFAEFDINNMK-KFGRFYGASFMGFPELNVCDMDMLRQIFIEDFAAFPNRVISDFFIGNQTIRK---NMVNVMTDQHWKDLRRTITPAF----------TPRRLEKMLPIMERCIRTAERIIDDCISRSNGLLDTKKFFSNLTMDIIAQCAFGVELSIQEHQDSLIPYHANKIFN---------LSFVGFRIMFLVLFPNIARLAEKIFKFQLIGNSCDAFFEDILRKIVEERRKCPREKDPDFLQLLMDSKED-TEVIDRDEELMHDALA-SGKKIA--------LTDMELIAQGYLFLVTGYETTANTLQFISYCLASNPQVQEIAHAQVMDTVG---HKKSIGYADLMKMPYLEQVMNETLRMYPPVPRND-RKCESDITVGG-VKIEKGTFVYLPTYAIHYNEHFY-PNPEKFDPERFSRSEKANRDP----VAFAPFGIGPRNCIGLRLAQMEIRLILAHLLRSFKFSVPEEFQGKLLELDTRGMTRPKTPVFVTVSRRNH----------------------------------------- As-CYP-3A31 -----------------------------------MHIGIGEYVIILLIIIGTTFYYLPLSAAVITVTSL------------------SSAIIWKLHCLNNYWAKQGIPGPKRNLIFGNLLQLMN-------GFKTFDIENTK-KYGKNFGAVFAGAPTFISSDVDLLREVLVKRFNCFINREIRSITYNENNVGS---KMLLVLKDQLWKDVRRTITPAF----------SSAKMKNMVTLLEECVADLINAFELAINERNGIFEAKELCGKYTMDAIAKCAFGVDVG-SQHGNSLFAKYAREILN---------FTLWDPRVLFITLFPNISRCIENFTGHEITNHKANKYIVDAIRKVIAERRIHRKAGKPDFLQLLLDCSDERCAESEIDREITDEIVAKSGNKVK--------LNDELIISQCFIFIVAGYETSSATLQFCLYNLATNPIVQENGHEEVMRIVG---DKELIEWDDLAKMSYIDHIIKETLRLFPPIPSIN-RQCNEEVFIDG-VKFEKGCNINAAVFAIHYNEEYY-PEAERFYPERFSLEKYKTNDP----LTFIPFGFGPRNCIGMRFAQLEMRLALAYLLKYYRFITNNKTPKPPLEITTLPFTKPNDPICLTAIRRSI----------------------------------------- As-CYP-4C1 ---------------------------------------------------MATL-VQLLFLLVFTFFCY------------------VRFWPYIVELRRRRKIAANIAGPTTSPLLGNALQFS--------RNPFEFLEHLLRLANEAVQSGEHLLRLWVADKLVVFPLDGEALKPIIESNTELVKGRDYDFFRPWLGDGLLTSSGNKWKSRRKMLTPAF----------HFKMLQEFVSVFDTESKILVEQL-DHFANTDCEVDILPFIKRCALDIICSTAMGVKVNAQIKHDSPYVIAVEKVTL--------------LGFEYSITPFYWLQPVWYASGKAQETKNAVEVLKSFTEKVIKERRANYSR-------VKKVD-----LHDKKKAAFLDMLLE-MQYDNK--------LSDEDIREEVDTFMFAGHDTTSTGIGWTLWCLATHPDVQEKAIEEVDSIFG--DGEMRITIDSLQQLKYVERCIKEAMRLFAPVPHVQ-RQLKNDILMGG-KIVPRGTNCIISPILVHRNLKVF-PNANDFDVDNFLPERIAQRHP----YSYIPFSAGPRNCIGQKFALLEEKTVIVSILRAFTMKCNLKLAENRCGAQVVLRPEQGFPIIFERRQTYP----------------------------------------- Ce-CYP-29A4 ---------------------------------------------------MSIL-IPVALALLFVYL--------------------LSFYDTIRLMRKFWIYGGKMPGPPAHPIFGNASLFKN-------KTTKDFVELFVQLAHEARSKGANLMRTQVMNRIYVWPLNGKTAATILESSTEVNKGDDYAFLVPWLGGGLLMEKGEKWKSHRRILTPAF----------HFAKLEGYLDVFNSESKILIDCL-EKIAETQETVDLFPFFKRCTLDIICGTAMGIKLDAQNVHNLGYVQAVEGFNK--------------LTVEYSLNPFLWNRFVYWALGYQKMHDDFLYTLKKFTNDAIVERRTVIAS-------GEIEK-----ETSKRKMNFLDILLN-SEESNE--------LTSDEIRKEVDTFMFAGHDTTSTSLSWLCWNIAHNPEVQENVYKEIISIFGE-DPNQDVTSENINRLEYTERVLKESKRMFPPVPGFQ-RKLTKDIVIDG-ITIPSEGNITISPTVLHCNPFVY-QNPEKFDPDRFLPEECAKRHS----YDYIPFSAGLRNCIGQKFSILNEKVMLIHILRNFKLEPKLEFYETKPLFEVVAKPSHGIPVKLIKRY-------------------------------------------- Ce-CYP-37B1 ---------------------------------------------------MHFLNIATIFLITIFLFYY------------------KLIYNFIRDRLRIYKYMRKFDGPYSFPIIGTLYMVNI-------FDISKFTTQSMELAQYYCQKGCGTIGLWLGPVPLIAVINPQHAKEILESNEVITKAEEYDILFPWLGTGLLTSTGSKWRQRRKMLTPAF----------HFKVLNDFLSVHDYQAKVFLEQI-KPYADSGKEVDLFPYIKRLALDVICDTSMGVTIDAQNNHDHQYVESVRLLSE--------------YAFEWILRPWLRLKPLWYLTGPGHEYDRHLKIVTDFTKTVIKEKWEEFQKFH-----VDPVV-----KTDKRSMAFLDLLLE-LRNEGL--------MNEDDIREEVDTFMFEGHDTTSASMGWTLWCLAHNPEFQEKVIQEVDGIFG--TSDRDCTNDDLKQMKYLEKCLKESLRMYPSVPFFG-RTVEQDVVING-DFFPKGVRIIVMPLLLQRNPLIF-DNPNQYNPENFSEDKIGSRHA----YSDIPFSAGPRNCIGQKFAMMEEKAVISWFFRKYRVTASQPFGMNKILPELILKSSLGFPLTVHHRTDNK----------------------------------------- Ss-CYP-6 --------------------------------------------------MSLLSTIFLSLILIFILKNI------------------KNIIKWYKERERKFLLGEKIPGPKRIPIIGNANLFQ--------GNIEDIVKRVEDEARIGLKNGDPLRRFWMGNDLVVHGLTSDARKVIFDSSVEIKKGFIYKFLAKWLGYGLITSDGDKWRERRKILTPTF----------HFNMLKKYFDSFNNESKVMIKHF-EKYCDKNIETEVYQYAKRAALDIICDTAMGVKINAQDNTDNEYIKAVEKINA--------------LASVFFKNILYRFEPFYYLFGNGFERDQLLKILTNFTSNVIKEKTKEFEKN----------------NGIMKDKTFLSHLLE-LKSENS--------LSDEDIREEVETFMFAGHDTTSSLNAFLWWSLACHPKIQDRVYEEIYDIFG--DEERDVTPEDINKLKYTEMVIKETLRRFPTVPFII-RRLINEVEVCG-YTVPKETNFCFPLIVANFNETIF-PDPYKFDPDRFSPENIAKRNA----YDFTPFSAGPRNCIGQKFALNEVKVVLCWMLRKYKLISKRPFDEVKGIAEVTYCPKEGPYIIFESRKSYL----------------------------------------- Ss-CYP-7 --------------------------------------------------MAVLQ-FILTLLCIYALSKI------------------KSIWIWYKIRNRKHELGDKISGPKGIPFFGNSLSFP--------KDTKKTIEYMTEEFNKVNEKNEPFIRFWIGEKLLVVPINGKAAKYIIDN--ELEKGADYDLLRQWLNEGLVVSSGEKWKHNRKLITPSF----------HFGMLKNYFSIFNNEGKIFVETL-TKYANTNNEVNIIKYAKRVALDVICETAMGTKMNTQKNPNHQYIENVEIINR--------------NAAIFTRNPLYLIKPIWYLFGEGFSTNRSLKILKDFTLNIINNRWKQYKQNNIDENNNNNDN-----NNNKEKHDFLKNLLD-YRAQNS--------MTDQDVLDEVQTFTFAGHDTTATAFSFLIWALSTHPDIQERLYEEICDVYE--FEERDVIPDDLTKLPYLDRVIKESLRRHPTIPIIL-RKINKEIDILG-YTLPKDTNFMISIYHIHFNHKIY-SDPMKFDPDRFLPENCATRDA----YDYIPFSAGPRNCIGQKFSLFELKTLVIWVLRKYKFHSNQPYDYIKLLPEVVIHNDKDYPILITTR--------------------------------------------- Ss-CYP-10 ---------------------------------------------------MLFYKILTIILSLIIYFVI------------------KKLYLWYKERKRIVYYLNKIPGDDGLPIIGNLLEFQ--------CSTAGLLDKTYEFIQWMNKNNTSILKKWIANHAIVYVSSPNAQKIILENPKETTKASTYNLLKEWLSEGLVTGSGDKWRHRRRLINPTF----------NFKMLLEYHVIFNEESKILVNVL-DKFKDTGKEIEVLEFMKRCLFDTILRTAFGHKLGSQENPDDTYLHAIENFAE--------------MAYVAAVNYFYRNKYIFYLSGNGFKKDGYLKILRKFANDLIQISYKKYLKDK---------E-----NGKIEHKTFISMLLE-EYENNE--------ITMDGIREEVDNIIFGGFDTSSSTMSWILWALATNPEIQEKVYEEIYDIFG--EEEKIVTFEDINKMTYFDMILKEVLRRFSIVSVST-RKLQNDVKIDG-YTIPKGVDVILGPFLINMNEKVF-PDPYKFDPDRFLPEISATRSA----FDFIPFSAGPRNCVGQKYANHVIKIISVWVLRRYKVRANYPMDYLKMLPQVITNSDKGFPIIFESRIK------------------------------------------- Bm-CYP-A --------------------------------------------------------MGLVSASLITLVLV------------------WIIHFVIKKLRTILKQINAVQGPPTWPLIGNLHQFHF-------KPDEFFEQAQGIAYMLQAR-GERMCRIWFGPCPWILLYGADECEAILGSNKILDKPFQYGFLSGWIGQGLLISEPKKWRSRRKLLTPTF----------HYDILKDFVGVYNKHGQTLLQKF-HALCGNQ-YNDIFHMISLCTLDIICEAALGTHVDAQ-NKSSPYLDAVCKIKY--------------IIHQRTLKAHFYFDTIYNIFGSGKDESKCTEILHEFTGAAIANRKRLVDEAGGVSSLMEKE-----TVSGKRRMAFLDFMLD-LNAKGE--------LPMEGVQEEVDTFTFEAHDSTSTSMNWFLHLMGTNPEIQAKVQKEVDEVLG--EENRSVTYEDLGQLRFLEACIKETLRLFPSVPMQA-RLLTEDTKIGN-KLLPCGMSVVIIASMVHRDPRYW-PDPEAFKPERFIDNQP--RHP----FSYIPFSAGPRNCIGQRFALMEEKCILALLMRNLKVKSKLRTDQMRVSAELVIRPLFGNNIRFEARKFGDYVQIA------------------------------------ Bm-CYP-B --------------------------------------------------------MGLVSASLITLVLV------------------WIIHFVIKKLRTILKQINAVQGPPTWPLIGNLHQFHF-------KPDEFFEQAQGIAYMLQAR-GERMCRIWFGPCPWILLYGADECEAILGS------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------KRRMAFLDFMLD-LNAKGE--------LPMEGVQEEVDTFTFEAHDTTSTSMNWFLHLMGTNPEIQAKVQKEVDEVLG--EENRSVTYEDLGQLRFLEACIKETLRLFPSVPMQA-RQLTKATKIGN-KILPRGTSVMIIASMIHRDPRYW-PDPEAFKPERFIDNQP--RHP----FSYIPFSAGPRNCIGQRFALMEEKCILALLMRNLKVKSKLRTDQMRVSAELVIRPLFGNNIRFEARKFGDYVQIA------------------------------------ Ss-CYP-8 --------------------------------------------------------MGAIGNTFLVISIT------------------LLLTFIIKKILYYLKTLQKVPGISTLPLIGNLHQIRI-------EPDKFYEQFQGIGYMLQNR-KDRICKVWFGPLPFVAIYGAEEIEGVLGSSKLLNKLFQYTFLSPWIGDGLLISKPDKWKPRRKLLTPAF----------HYDILKDFVYIFNKHAKTLIGKF-DKLADKEEFVDIFHTISLCTLDIICEAALGIDIKAQ-TVQTEYLEAVFKMKY--------------IIHQRQIKPQYYSDVVFNLVGDGKEHDKCVKILHDFTHSVIDKRKKMAEEYGGIRKLMERER----HEDSSYKMAFLDLMLE-MNAKGD--------LPIEGLLEEVDTFTFEGHDTTSAALNWFLHLMAANPEIQAKVHKEIDDVLG--DEIRPVNFDEIGRLKYLEACVKETLRLYPSVPLFG-RSTTEEVEING-YKIPPNTGIAIISAMVHKDPKYW-KNPEIFNPERFIDNDL--KHP----YCYIPFSAGSRNCIGQRFAMMEEKCLVANIMRQFKVQTQVRTDEMRLSAELIIRPMFGNHIKFIKRSYGDYNLVEPPH--------------------------------- Ts-CYP-4V2 --------------------------------------------------------MGAVAVAVVATGII------------------TALICWMLKLRKLTALVDRFPGPRYFPILGNIPYFKK-------DPTEFFEQTIGTAYAYNN---PRIFRVWMFWYPFFVVSGAEEAEVLLSSTKHINKGMEYRMLHPWMGLGLLTSDAFKWRPRRKLLTPSF----------HYDILKDFIEVFNQQSKIMLKKLSDNLDISNEGFNMYQYITLCALDIICETAMGRHVNAQKNSDSDYVRAIYKLNR--------------IIHERQKKPHLWPNIIFRLFGEGKEQEECLKILHSFTWKVIQERREEVKQLGGWAKVLDRQMTDFEMTSQKRRLAFLDLLLQ-IAEQGK--------LTDQDIREEVDTFMFEVN--------------------QKKLQIQFDD-------DRDATFEDVKNMTYLECCLKEALRLFPSVPLFA-RFINEDFDIGG-LTIPSGSEVIVSPYGVHRDPRHW-PDPEIFDPDRFLPKNANGRHP----FAYLPFSAGSRNCIGQRFALMEEKVVVSWILRYFEVTSVQRRDQIFPKAELIIRPTETILIKLKRRQPLSFA--------------------------------------- Ce-CYP-36A1 --------------------------------------------------------MLFAQLVILVII------------------------VMLFLCRFANKLRGLPPGPTPWPFIGNTFQVPE-------DRIDLIINEFKKKYGGIFTLWLP-FPTIVICDYDMLKRNIVKNGESFSGRPDTFIMDMLVQGN----YGLFFMENNWWKAQRRFTTHIFRSL-----GVGQAGTQDTIASLASGLVEKIDGQKDK------PIELRPLLVHVVGNVIHKHLFGFTRE--WNETEILDFHVAINDV-----------------LEHFTSPKTQLLDAWP-----WLAYLDKPLSLGIPRTTRANDAIIQNLEQALAKHKTGIN-----YDEEPSSYMDAFLKEMKIRAAEN-ALEDGFTEKQLIVAIYDLYSAGMETIIIVLRFAFLYLVNNPETQKRIHEELDRNVGR---ERQVVMDDQKHLPYTCAFLQEVYRLGYVLPVNFLRCTLTDVEDCEGYRLNAGTRVIAQFQSVHVDKKHF-PDPEHFNPDRFLNSRGEYIRD----DRVNPFSMGKRSCLGENLARMEVFLYFCTLMQNFEWHTDGPYAPPIDVITSS--LRAPKPFTVRASRR------------------------------------------- Dm-CYP-18A1 --------------------------------------MLADSYLIKFVLRQLQVQQDGDAQHLLMVFLG----------------LLALVTLLQWLVRNYRELRKLPPGPWGLPVIGYLLFMGS--------EKHTRFMELAKQYGSLFSTRLGSQLTVVMSDYKMIRECFRREE--FTGRPDTPFMQTLN------GYGIINSTGKLWKDQRRFLHDKLRQFGMTYMGNGKQQMQKRIMTEVHEFIGHLHASDGQ------PVDMSPVISVAVSNVICSLMMSTRFS--IDDPKFRRFNFLIEEG-----------------MRLFGEIHTVDYIP--------TMQCFPSISTAKNKIAQNRAEMQRFYQDVIDDHKRSFD---PNNIRDLVDFYLCEIEKAKAEGTDAELFDGKNHEEQLVQVIIDLFSAGMETIKTTLLWINVFMLRNPKEMRRVQDELDQVVGR---HRLPTIEDLQYLPITESTILESMRRSSIVPLATTHSPTRDVELNG-YTIPAGSHVIPLINSVHMDPNLW-EKPEEFRPSRFIDTEGKVRKP----EYFIPFGVGRRMCLGDVLARMELFLFFASFMHCFDIALPEGQPLPSLKGNVG-ATITPESFKVCLKRRPLGPTAADPHHMRNVGAN------------------------- Hs-CYP17A -------------------------------------------------------MWELVALLLLTLA-------------------------YLFWPKRRCPGAKYPKSLLSLPLVGSLPFLPR------HGHMHNNFFKLQKKYGPIYSVRMGTKTTVIVGHHQLAKEVLIKKGKDFSGRPQMATLDIASNNRK---GIAFADSGAHWQLHRRLAMATFALFK-----DGDQKLEKIICQEISTLCDMLATHNGQ------SIDISFPVFVAVTNVISLICFNTSYK---NGDPELNVIQNYNEG-------------------IIDNLSKDSLVDLVP----WLKIFPNKTLEKLKSHVKIRNDLLNKILENYKEKFRSDS-----ITNMLDTLMQAKMNSDNGNAG-PDQDSELLSDNHILTTIGDIFGAGVETTTSVVKWTLAFLLHNPQVKKKLYEEIDQNVG---FSRTPTISDRNRLLLLEATIREVLRLRPVAPMLIPHKANVDSSIGE-FAVDKGTEVIINLWALHHNEKEW-HQPDQFMPERFLNPAGTQLIS-PS-VSYLPFGAGPRSCIGEILARQELFLIMAWLLQRFDLEVPDDGQLPSLEGIPKVVFLIDSFKVKIKVRQAWREAQAEGST-------------------------------- Hs-CYP21B -------------------------------------------------------MLLLGLLLLLPLLAG---------------------------ARLLWNWWKLRSLHLPPLAPGFLHLLQP--------DLPIYLLGLTQKFGPIYRLHLGLQDVVVLNSKRTIEEAMVKKWADFAGRPEPLTYKLVSKNYP---DLSLGDYSLLWKAHKKLTRSALLLG-------IRDSMEPVVEQLTQEFCERMRAQPG------TPVAIEEEFSLLTCSIICYLTFGDKIK---DDNLMPAYYKCIQEV-----------------LKTWSHWSIQIVDVIP-----FLRFFPNPGLRRLKQAIEKRDHIVEMQLRQHKESLVAG------QWRDMMDYMLQGVAQPSMEEG-----SGQLLEGHLHMAAVDLLIGGTETTANTLSWAVVFLLHHPEIQQRLQEELDHELGPGASSSRVPYKDRARLPLLNATIAEVLRLRPVVPLALPHRTTRPSSISG-YDIPEGTVIIPNLQGAHLDETVW-ERPHEFWPDRFLEPGKN--------SRALAFGCGARVCLGEPLARLELFVVLTRLLQAFTLLPSGDALPSLQPLPHCSVILKMQPFQVRLQPRGMGAHSPGQNQ-------------------------------- Ts-TAS-A -----------------------------MVASVSKKQLLLLRKTNEKQSYCTSINYQVLNRQRLAFFNR------------------FCTRFSLRISAFRLRSKLGLRGPKPNLLFGNVLEFIDPNVK-WEEDQSVLFKKLKRQYGDVYGIYLGPQLNVVVTDLDVARDILIKNFSCFTDRSNIAILEKKPMS-----ECLFNLRQQEWKDIRSTVVHTFSNR-------IMREVMHMASSCLPKIMKFLDGLDSYAASG-TAFDIYKFHIVLTVDVIAQCAFALDLDLNESQNRQFLDNCRQLFDG--------------------------------------YDFNESWLILIFPEMIWFLKPFVSFTKFSKAEQRIVN------------DLREVLLRKKHLKGT-------PLTDDAIVANAMVFLLAGYETSSTAMGFAAWLLAKHPEVQEKLRQEVNVKFND--IQIGQEYDVIHDMPYMNAVMQETLRLYPPLVLLVVRTCIKECTINEIPFVP-GVQVLFPTYSIHHDETIW-PEPDRFLPERFIGSDCAHHPM-----AWLPFGAGPRNCIGKRFAEMQFKITMAHLLKRYRLHLSEAESEDPIKLKCNGATIRPRNGVVIKLSRY------------------------------------------ Hs_CYP27A1 ----------------------------------MAALGCARLRWALRGAGRGLCPHGARAKAAIPAALP--------------------SDKATGAPGAGPGVRRRQRSLEEIPRLGQLRFFFQLFVQGYALQLHQLQVLYKAKYGPMWMSYLGPQMHVNLASAPLLEQVMRQEGKYPVRNDMELWKEHRDQHD--LTYGPFTTEGHHWYQLRQALNQRLLKP------AEAALYTDAFNEVIDDFMTRLDQLRAESASGNQVSDMAQLFYYFALEAICYILFEKRIGCLQRSIPEDTVTFVRSIG-----------------LMFQNSLYATFLPKWTR----PVLPFWKRYLDGWNAIFSFGKKLIDEKLEDMEAQLQAAG----PDGIQVSGYLHFLLASGQLSPR------------EAMGSLPELLMAGVDTTSNTLTWALYHLSKDPEIQEALHEEVVGVVPA---GQVPQHKDFAHMPLLKAVLKETLRLYPVVPTNS-RIIEKEIEVDG-FLFPKNTQFVFCHYVVSRDPTAF-SEPESFQPHRWLRNSQPATPRIQHPFGSVPFGYGVRACLGRRIAELEMQLLLARLIQKYKVVLAPETGELKSVARIVLVPNKKVGLQFLQRQC------------------------------------------- ; end;