Fig 1.
PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) flow diagram of the studies identified, screened, and assessed for eligibility.
Table 1.
Summary of the results of the seven studies eligible for the systematic review on genetic susceptibility to Paracoccidioidomycosis (PCM). The data shows the name of the gene, the mutation position, the reference SVP ID, the genotype, the number (N) and percentage (%) of patients with PCM and healthy individuals (control), Hardy-Weinberg Equilibrium (HWE) Deviation, Genetic Model tested, the Odds Ratio, 95% Confidence Interval (95% CI), p-value, p-value adjustment type, Minor Allele Frequence (MAF), observed (OSS) and expected sample size (ESS), and reference. NS: not significant. NR: Not Reported. CTLA4: cytotoxic T-lymphocyte associated protein 4; CD209: CD209 molecule; FCGR2A: Fc gamma receptor IIa; IFNG: interferon gamma; IL10: interleukin 10; IL12A: interleukin 12A; IL12B: interleukin 12B; IL12RB1: interleukin 12 receptor subunit beta 1; IL18: interleukin 18; IL4: interleukin 4; JAK1: Janus kinase 1; TNF: tumor necrosis factor; VDR: vitamin D receptor. ¹HWE Deviation: *No deviation.
Fig 2.
Sample size and collection site of case and control groups, as well as the number of Single Nucleotide Variants analyzed in seven studies that evaluated genetic susceptibility to Paracoccidioidomycosis in Brazil.
The map was generated using ArcGIS 10.1 (ESRI, California) and GADM layers (https://gadm.org/download_country.html) under CC BY 4.0 license. Icons were were taken from the World Atlas of Wikimedia (https://commons.wikimedia.org; DNA: https://commons.wikimedia.org/wiki/File:202202_DNA_colored.svg; Man: https://commons.wikimedia.org/wiki/File:Frankie_Pappas_Icon.png).
Fig 3.
Risk of bias assessment of seven case-control studies included in the systematic review, based on the Joanna Briggs Institute (JBI) Critical Appraisal Checklist.
Most studies were classified as presenting moderate to high risk of bias.
Fig 4.
Meta-analysis of two case-control genetic association studies evaluating the Interferon gamma (IFNG rs2430561) single nucleotide variant (SNV) and susceptibility to paracoccidioidomycosis, considering the AA, TA, and TT genotypes.
Meta-analysis was performed using the Mantel-Haenszel method in the fixed-effect model. The size of each box indicates the weight of the study in the pooled results. OR: odds ratio.
Fig 5.
Meta-analysis of two case-control genetic association studies evaluating the Interleukin 4 (IL4 rs2243250) single nucleotide variant (SNV) and susceptibility to paracoccidioidomycosis, considering the CC, CT, and TT genotypes.
Meta-analysis was performed using the Mantel-Haenszel method in the fixed-effect model. The size of each box indicates the weight of the study in the pooled results. OR: odds ratio.
Fig 6.
Meta-analysis of two case-control genetic association studies evaluating the Tumor Necrosis Factorα (TNFα rs1800629) single nucleotide variant (SNV) and susceptibility to paracoccidioidomycosis, considering the AA, GA, and GG genotypes. Meta-analysis was performed using the Mantel-Haenszel method in the fixed-effect model. The size of each box indicates the weight of the study in the pooled results. OR: odds ratio.