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Selective Inhibitors of Protozoan Protein N-myristoyltransferases as Starting Points for Tropical Disease Medicinal Chemistry Programs

Figure 7

Plot of dose-response activity against Ldon vs. Hs1 NMTs for primary screening hit and analogue screening set.

In contrast to Figure 6, a plot of potency against Ldon and Hs1 NMTs showed that activity did not correlate. Excellent selectivity was observed for several chemical series. The structures of representative members of four series are given in Figure 5.

Figure 7