Genome-wide analysis of ivermectin response by Onchocerca volvulus reveals that genetic drift and soft selective sweeps contribute to loss of drug sensitivity

• Stephen R. Doyle ,

  Contributed equally to this work with: Stephen R. Doyle, Catherine Bourguinat

  Roles Data curation, Formal analysis, Funding acquisition, Investigation, Software, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sd21@sanger.ac.uk (SRD); roger.prichard@mcgill.ca (RKP); w.grant@latrobe.edu.au (WNG)

  Affiliations Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Australia, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom

  http://orcid.org/0000-0001-9167-7532

  ⨯
• Catherine Bourguinat ,

  Contributed equally to this work with: Stephen R. Doyle, Catherine Bourguinat

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Institute of Parasitology, McGill University, Sainte Anne-de-Bellevue, Québec, Canada

  ⨯
• Hugues C. Nana-Djeunga,

  Roles Investigation, Writing – review & editing

  Affiliations Parasitology and Ecology Laboratory, Department of Animal Biology and Physiology, Faculty of Science, University of Yaoundé 1, Yaoundé, Cameroon, Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaoundé, Cameroon

  ⨯
• Jonas A. Kengne-Ouafo,

  Roles Investigation, Writing – review & editing

  Affiliation Research Foundation in Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon

  ⨯
• Sébastien D. S. Pion,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation Institut de Recherche pour le Développement (IRD), IRD UMI 233 TransVIHMI – Université Montpellier – INSERM U1175, Montpellier, France

  ⨯
• Jean Bopda,

  Roles Investigation, Writing – review & editing

  Affiliation Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon

  ⨯
• Joseph Kamgno,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliations Centre for Research on Filariasis and other Tropical Diseases (CRFilMT), Yaoundé, Cameroon, Faculty of Medicine and Biomedical Sciences, University of Yaoundé 1, Yaoundé, Cameroon

  ⨯
• Samuel Wanji,

  Roles Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation Research Foundation in Tropical Diseases and the Environment (REFOTDE), Buea, Cameroon

  ⨯
• Hua Che,

  Roles Investigation, Writing – review & editing

  Affiliation Institute of Parasitology, McGill University, Sainte Anne-de-Bellevue, Québec, Canada

  ⨯
• Annette C. Kuesel,

  Roles Data curation, Investigation, Project administration, Writing – review & editing

  Affiliation UNICEF/UNDP/World Bank/World Health Organization Special Programme for Research and Training in Tropical Diseases (WHO/TDR), World Health Organization, Geneva, Switzerland

  ⨯
• Martin Walker,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Current address: London Centre for Neglected Tropical Disease Research, Department of Pathobiology and Population Sciences, Royal Veterinary College, Hatfield, United Kingdom

  Affiliation London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London, United Kingdom

  ⨯
• Maria-Gloria Basáñez,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation London Centre for Neglected Tropical Disease Research, Department of Infectious Disease Epidemiology, Faculty of Medicine, School of Public Health, Imperial College London, United Kingdom

  ⨯
• Daniel A. Boakye,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Noguchi Memorial Institute for Medical Research, University of Ghana, Legon, Ghana

  ⨯
• Mike Y. Osei-Atweneboana,

  Roles Data curation, Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation Department of Environmental Biology and Health Water Research Institute, Council for Scientific and Industrial Research (CSIR), Accra, Ghana

  ⨯
• Michel Boussinesq,

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation Institut de Recherche pour le Développement (IRD), IRD UMI 233 TransVIHMI – Université Montpellier – INSERM U1175, Montpellier, France

  ⨯
• Roger K. Prichard ,

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Resources, Writing – review & editing

  * E-mail: sd21@sanger.ac.uk (SRD); roger.prichard@mcgill.ca (RKP); w.grant@latrobe.edu.au (WNG)

  Affiliation Institute of Parasitology, McGill University, Sainte Anne-de-Bellevue, Québec, Canada

  ⨯
•  [ ... ],
• Warwick N. Grant

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: sd21@sanger.ac.uk (SRD); roger.prichard@mcgill.ca (RKP); w.grant@latrobe.edu.au (WNG)

  Affiliation Department of Animal, Plant and Soil Sciences, La Trobe University, Bundoora, Australia

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