Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections

Eleonora Cimini; Domenico Viola; Mar Cabeza-Cabrerizo; Antonella Romanelli; Nicola Tumino; Alessandra Sacchi; Veronica Bordoni; Rita Casetti; Federica Turchi; Federico Martini; Joseph A. Bore; Fara Raymond Koundouno; Sophie Duraffour; Janine Michel; Tobias Holm; Elsa Gayle Zekeng; Lauren Cowley; Isabel Garcia Dorival; Juliane Doerrbecker; Nicole Hetzelt; Jonathan H. J. Baum; Jasmine Portmann; Roman Wölfel; Martin Gabriel; Osvaldo Miranda; Graciliano Díaz; José E. Díaz; Yoel A. Fleites; Carlos A. Piñeiro; Carlos M. Castro; Lamine Koivogui; N’Faly Magassouba; Boubacar Diallo; Paula Ruibal; Lisa Oestereich; David M. Wozniak; Anja Lüdtke; Beate Becker-Ziaja; Maria R. Capobianchi; Giuseppe Ippolito; Miles W. Carroll; Stephan Günther; Antonino Di Caro; César Muñoz-Fontela; Chiara Agrati

doi:10.1371/journal.pntd.0005645

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Open Access

Peer-reviewed

Research Article

Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections

Eleonora Cimini,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Domenico Viola,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Mar Cabeza-Cabrerizo,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany
⨯
Antonella Romanelli,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Nicola Tumino,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Alessandra Sacchi,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Veronica Bordoni,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Rita Casetti,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Federica Turchi,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Federico Martini,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Joseph A. Bore,

Affiliation European Mobile Laboratory Consortium, Hamburg, Germany
⨯
Fara Raymond Koundouno,

Affiliation European Mobile Laboratory Consortium, Hamburg, Germany
⨯
Sophie Duraffour,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany
⨯
Janine Michel,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Robert Koch Institute, Berlin, Germany
⨯
Tobias Holm,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany
⨯
Elsa Gayle Zekeng,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Lauren Cowley,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, National Infection Service, Public Health England, Porton Down and Colindale, United Kingdom
⨯
Isabel Garcia Dorival,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Institute of Infection and Global Health, University of Liverpool, Liverpool, United Kingdom
⨯
Juliane Doerrbecker,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, Centre for Experimental and Clinical Infection Research (TWINCORE), Institute for Experimental Virology, Hannover, Germany
⨯
Nicole Hetzelt,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Robert Koch Institute, Berlin, Germany
⨯
Jonathan H. J. Baum,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany
⨯
Jasmine Portmann,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Federal Office for Civil Protection, Spiez Laboratory, Switzerland
⨯
Roman Wölfel,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Bundeswehr Institute of Microbiology, Munich, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany
⨯
Martin Gabriel,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany
⨯
Osvaldo Miranda,

Affiliation Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba
⨯
Graciliano Díaz,

Affiliation Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba
⨯
José E. Díaz,

Affiliation Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba
⨯
Yoel A. Fleites,

Affiliation Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba
⨯
Carlos A. Piñeiro,

Affiliation Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba
⨯
Carlos M. Castro,

Affiliation Hospital Militar Central Dr. Carlos J. Finlay, Havana, Cuba
⨯
Lamine Koivogui,

Affiliation Institut National de Santé Publique, Conakry, Guinea
⨯
N’Faly Magassouba,

Affiliation Laboratoire des Fièvres Hémorragiques en Guinée, Université Gamal Abdel Nasser de Conakry, Conakry, Guinea
⨯
Boubacar Diallo,

Affiliation World Health Organization, Geneva, Switzerland. (Boubacar is separate: World Health Organization, Conakry, Guinea)
⨯
Paula Ruibal,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
⨯
Lisa Oestereich,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany
⨯
David M. Wozniak,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany
⨯
Anja Lüdtke,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
⨯
Beate Becker-Ziaja,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany
⨯
Maria R. Capobianchi,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Giuseppe Ippolito,

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy
⨯
Miles W. Carroll,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, National Infection Service, Public Health England, Porton Down and Colindale, United Kingdom, University of Southampton, South General Hospital, Southampton, United Kingdom
⨯
Stephan Günther,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany
⨯
Antonino Di Caro,

Affiliations Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy, European Mobile Laboratory Consortium, Hamburg, Germany
⨯
César Muñoz-Fontela,

Affiliations European Mobile Laboratory Consortium, Hamburg, Germany, Department of Virology, Bernhard Nocht Institute for Tropical Medicine, World Health Organization Collaborating Center for Arbovirus and Hemorrhagic Fever Reference and Research, Hamburg, Germany, German Center for Infection Research (DZIF), Partner Sites Hamburg, Munich, Germany, Heinrich Pette Institute, Leibniz Institute for Experimental Virology, Hamburg, Germany
⨯
[ ... ],
Chiara Agrati

* E-mail: chiara.agrati@inmi.it

Affiliation Department of Epidemiology and Pre-clinical research, National Institute for Infectious Diseases “Lazzaro Spallanzani”, Rome, Italy

http://orcid.org/0000-0002-5252-0927

⨯
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Different features of Vδ2 T and NK cells in fatal and non-fatal human Ebola infections

Eleonora Cimini,
Domenico Viola,
Mar Cabeza-Cabrerizo,
Antonella Romanelli,
Nicola Tumino,
Alessandra Sacchi,
Veronica Bordoni,
Rita Casetti,
Federica Turchi,
Federico Martini

Published: May 30, 2017
https://doi.org/10.1371/journal.pntd.0005645

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