HLA-A2 and B35 Restricted Hantaan Virus Nucleoprotein CD8+ T-Cell Epitope-Specific Immune Response Correlates with Milder Disease in Hemorrhagic Fever with Renal Syndrome

Ying Ma; Jiuping Wang; Bin Yuan; Meiliang Wang; Yun Zhang; Zhuwei Xu; Chunmei Zhang; Yusi Zhang; Bei Liu; Jing Yi; Kun Yang; Angang Yang; Ran Zhuang; Boquan Jin

doi:10.1371/journal.pntd.0002076

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Open Access

Peer-reviewed

Research Article

HLA-A2 and B35 Restricted Hantaan Virus Nucleoprotein CD8⁺ T-Cell Epitope-Specific Immune Response Correlates with Milder Disease in Hemorrhagic Fever with Renal Syndrome

Ying Ma ,

Contributed equally to this work with: Ying Ma, Jiuping Wang

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Jiuping Wang ,

Contributed equally to this work with: Ying Ma, Jiuping Wang

Affiliation Department of Infectious Diseases of Tangdu Hospital, the Fourth Military Medical University, Xi'an, China
⨯
Bin Yuan,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Meiliang Wang,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Yun Zhang,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Zhuwei Xu,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Chunmei Zhang,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Yusi Zhang,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Bei Liu,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Jing Yi,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Kun Yang,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Angang Yang,

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Ran Zhuang ,

* E-mail: immu_zr@yahoo.com (RZ); immu_jin@fmmu.edu.cn (BJ)

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯
Boquan Jin

* E-mail: immu_zr@yahoo.com (RZ); immu_jin@fmmu.edu.cn (BJ)

Affiliation Department of Immunology, the Fourth Military Medical University, Xi'an, China
⨯

HLA-A2 and B35 Restricted Hantaan Virus Nucleoprotein CD8⁺ T-Cell Epitope-Specific Immune Response Correlates with Milder Disease in Hemorrhagic Fever with Renal Syndrome

Ying Ma,
Jiuping Wang,
Bin Yuan,
Meiliang Wang,
Yun Zhang,
Zhuwei Xu,
Chunmei Zhang,
Yusi Zhang,
Bei Liu,
Jing Yi

Published: February 28, 2013
https://doi.org/10.1371/journal.pntd.0002076

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